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Synthesis, physicochemical characterisation and DNA binding study of a novel azo Schiff base Ni(II) complex
Uttam Kumar Singha (1) , Sudarshan Pradhan (2) , Dipu Kumar Mishra (3) , Pritika Gurung (4) , Anmol Chettri (5) , Biswajit Sinha (6,*)
(1) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(2) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(3) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(4) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(5) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(6) Department of Chemistry, University of North Bengal, Siliguri, 734013, India
(*) Corresponding Author
Received: 30 Nov 2022 | Revised: 02 Mar 2023 | Accepted: 11 Mar 2023 | Published: 30 Jun 2023 | Issue Date: June 2023
The azo Schiff base ligand was synthesised, along with its Ni(II) complex, by diazotisation of salicylaldehyde with 4-nitroaniline in accordance with the accepted literature approach. Using a variety of spectroscopic techniques, the resulting complex is analysed both quantitatively and qualitatively (Elemental analysis, FT-IR spectroscopy, UV-VIS spectroscopy, 1H NMR, etc.). Spectral measurements of the complex revealed a mole ratio of 1:1. The non-electrolytic nature of the complex is confirmed by molar conductance investigation. The unique azo compound had a tetrahedral shape as a result of the tetra coordination of two phenolic oxygen and two imine nitrogen. The ability of the metal complexes to bind DNA was examined using absorption spectroscopy, fluorescence spectroscopy, viscosity tests, and thermal denaturation methods. Experimental research suggests that complexes bind to DNA through intercalation.
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Departmental Special Assistance Scheme under the University Grants Commission, New Delhi (SAP-DRS-III, No.540/12/DRS/2013) and the University of North Bengal, Government of West Bengal for financial and instrumental support.
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DOI Link: https://doi.org/10.5155/eurjchem.14.2.280-286.2375
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