European Journal of Chemistry

Synthesis, physicochemical characterisation and DNA binding study of a novel azo Schiff base Ni(II) complex

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Published: Jun 30, 2023
DOI: https://doi.org/10.5155/eurjchem.14.2.280-286.2375
Keywords:
CT-DNA, Ni(II) complex, Azo Schiff base, DNA binding study, Molecular docking, DNA cleavage study
Section
Research Article
Issue
Vol. 14 No. 2 (2023): June 2023
Dates
Received 2022-11-30
Accepted 2022-12-30
Published 2023-06-30
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Uttam Kumar Singha
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0003-4460-0676
Sudarshan Pradhan
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0002-6963-8980
Dipu Kumar Mishra
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0002-0743-5627
Pritika Gurung
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0003-2074-0711
Anmol Chettri
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0002-7939-238X
Biswajit Sinha
Department of Chemistry, University of North Bengal, Siliguri, 734013, India
https://orcid.org/0000-0003-0468-4035

Abstract

The azo Schiff base ligand was synthesised, along with its Ni(II) complex, by diazotisation of salicylaldehyde with 4-nitroaniline in accordance with the accepted literature approach. Using a variety of spectroscopic techniques, the resulting complex is analysed both quantitatively and qualitatively (Elemental analysis, FT-IR spectroscopy, UV-VIS spectroscopy, 1H NMR, etc.). Spectral measurements of the complex revealed a mole ratio of 1:1. The non-electrolytic nature of the complex is confirmed by molar conductance investigation. The unique azo compound had a tetrahedral shape as a result of the tetra coordination of two phenolic oxygen and two imine nitrogen. The ability of the metal complexes to bind DNA was examined using absorption spectroscopy, fluorescence spectroscopy, viscosity tests, and thermal denaturation methods. Experimental research suggests that complexes bind to DNA through intercalation.


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Singha, U. K.; Pradhan, S.; Mishra, D. K.; Gurung, P.; Chettri, A.; Sinha, B. Synthesis, Physicochemical Characterisation and DNA Binding Study of a Novel Azo Schiff Base Ni(II) Complex. Eur. J. Chem. 2023, 14, 280-286.

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