Synthesis, crystal structure, and spectroscopic characterization of a new non-centrosymmetric compound, 1-(2-chloroquinolin-3-yl)-N-(4-fluorobenzyl)methanimine

Abstract

In this work, we report the synthesis and characterization of a new condensed aromatic heterocycle (1-(2-chloroquinolin-3-yl)-N-(4-fluorobenzyl)methanimine) useful in various fields, mainly in medicinal and therapeutic chemistry, with interesting biological properties. Characterization of the title compound was carried out by ¹H, ¹³C, ¹⁹F nuclear magnetic resonance and X-ray diffraction techniques. The crystal structure reveals that title compound crystallizes in the monoclinic system and crystal data for C₁₇H₁₂ClFN₂: monoclinic, space group P2₁ (no. 4), a = 7.2253(10) Å, b = 5.7720(10) Å, c = 17.105(2) Å, β = 95.338(10)°, V = 710.26(18) Å³, Z = 2, T = 298(2) K, μ(MoKα) = 0.274 mm^-1, Dcalc = 1.397 g/cm³, 5010 reflections measured (4.784° ≤ 2Θ ≤ 54.324°), 3160 unique (R_int = 0.0501, R_sigma = 0.0506) which were used in all calculations. The final R₁ was 0.0339 (I > 2σ(I)) and wR₂ was 0.0907 (all data). The obtained molecular structure has an antiparallel arrangement of the molecular unit leading to a one-dimensional framework.