European Journal of Chemistry 2011, 2(2), 243-250 | doi: https://doi.org/10.5155/eurjchem.2.2.243-250.257 | Get rights and content

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Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents


Hassan Mostafa Faidallah (1,*) , Khalid Ali Khan (2) , Abdullah Mohammad Asiri (3)

(1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia
(3) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia
(*) Corresponding Author

Received: 19 Aug 2010 | Revised: 24 Feb 2011 | Accepted: 04 Nov 2010 | Published: 30 Jun 2011 | Issue Date: June 2011

Abstract


Arylhydrazines reacted with dehydroacetic acid (1) to give the corresponding 2H-pyran-2-one hydrazones (2), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2H-pyridin-2-ones (3). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2H-pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities.2_2_243_250_800


Keywords


2H-pyran-2-one hydrazones; 1-Amino-2H-pyridin-2-ones; Benzenesulfonylurea derivatives; Thiourea derivatives; Antimicrobial activity; Antimycobacterial activity

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DOI: 10.5155/eurjchem.2.2.243-250.257

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How to cite


Faidallah, H.; Khan, K.; Asiri, A. Eur. J. Chem. 2011, 2(2), 243-250. doi:10.5155/eurjchem.2.2.243-250.257
Faidallah, H.; Khan, K.; Asiri, A. Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents. Eur. J. Chem. 2011, 2(2), 243-250. doi:10.5155/eurjchem.2.2.243-250.257
Faidallah, H., Khan, K., & Asiri, A. (2011). Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents. European Journal of Chemistry, 2(2), 243-250. doi:10.5155/eurjchem.2.2.243-250.257
Faidallah, Hassan, Khalid Ali Khan, & Abdullah Mohammad Asiri. "Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents." European Journal of Chemistry [Online], 2.2 (2011): 243-250. Web. 24 Sep. 2021
Faidallah, Hassan, Khan, Khalid, AND Asiri, Abdullah. "Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

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