European Journal of Chemistry

An efficient method for the synthesis of N-(4-halophenacyl)-2-substituted-benzo[d]imidazoles using PEG-400 as green reaction solvent

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Published: Jun 30, 2026
DOI: https://doi.org/10.5155/eurjchem.17.2.155-160.2771
Keywords:
PEG-400, Green method, Aromatic aldehydes, o-Phenylenediamine, 4-Halophenacylbromide, N-Substituted benzimidazoles
Section
Research Article
Issue
Vol. 17 No. 2 (2026): June 2026
Dates
Received 2026-01-09
Accepted 2026-04-12
Published 2026-06-30
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Shankaraiah Konda
Post Graduate and Research Center in Chemistry, Department of Chemistry, Faculty of Science and Technology, Karamshibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, District-Ahilyanagar, Pin-423601, Maharashtra, India
https://orcid.org/0000-0002-1939-6784
Sanket Jore
Post Graduate and Research Center in Chemistry, Department of Chemistry, Faculty of Science and Technology, Karamshibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, District-Ahilyanagar, Pin-423601, Maharashtra, India
https://orcid.org/0009-0009-5513-2776
Rupali Jeughale
Post Graduate and Research Center in Chemistry, Department of Chemistry, Faculty of Science and Technology, Karamshibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, District-Ahilyanagar, Pin-423601, Maharashtra, India
https://orcid.org/0009-0004-2516-1203
Sadashiv Nagre
Post Graduate and Research Center in Chemistry, Department of Chemistry, Faculty of Science and Technology, Karamshibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, District-Ahilyanagar, Pin-423601, Maharashtra, India
https://orcid.org/0000-0002-7335-7268

Abstract

In this paper, we report a green and efficient method for the synthesis of N-substituted benzimidazoles under grinding conditions using PEG-400 as reaction solvent at room temperature. 2-Substituted-1H-benzimidazole was prepared from the reaction between various aromatic aldehydes and o-phenylenediamine in mortar and pestle under a grinding process using NH4Cl as catalyst in PEG-400 as green reaction solvent. Additionally, 2-substituted-1H- benzimidazole were treated with 4-halophenacylbromide in the K2CO3 / PEG system, yielding the corresponding 1-(4-fluoro/bromophenacyl)-2-susbtituted-benzo[d]imidazole (N-substituted benzimidazoles). This methodology incorporates inexpensive catalysts, suppressed reaction times, high yields, easy work-up, and the use of green reaction solvents are reported. All of the structures of products were established by spectroscopic and analytical methods. The IR spectra of 2-substituted-1H-benzimidazole (2a-e) showed the disappearance of the stretching frequency band at 1680-1695 cm-1 due to >C=O of aromatic aldehydes and the presence of stretching bands at 1610-1630 cm-1 due to -C=N stretching, which confirms the formation products. Furthermore, 1H NMR spectra of N-substituted benzimidazoles (4a-j) showed the presence of a singlet at δ 6.10-6.25 ppm, indicating the presence of -CH2 in the structure of the phenacyl ring. The mass spectra (EIMS) of the compounds also agree with their molecular formula.


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Konda, S.; Jore, S.; Jeughale, R.; Nagre, S. An Efficient Method for the Synthesis of N-(4-Halophenacyl)-2-Substituted-benzo[d]imidazoles Using PEG-400 As Green Reaction Solvent. Eur. J. Chem. 2026, 17, 155-160.

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Department of Chemistry, Faculty of Science and Technology, Karamshibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, District-Ahilyanagar, Maharashtra, India and The Department of Biotechnology-Star College Scheme, New Delhi (File No: HRD-11011/18/2024-HRD-DBT), India.
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