

Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives
Lingappa Mallesha (1)


(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006,
(*) Corresponding Author
Received: 14 Sep 2010 | Revised: 09 May 2011 | Accepted: 05 Jan 2011 | Published: 30 Jun 2011 | Issue Date: June 2011
Abstract
A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method.
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DOI: 10.5155/eurjchem.2.2.193-199.282
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University Grants Commission, New Delhi, India
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