European Journal of Chemistry 2011, 2(2), 193-199 | doi: https://doi.org/10.5155/eurjchem.2.2.193-199.282 | Get rights and content

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Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives


Lingappa Mallesha (1) , Kikkeri Narasimhasetty Mohana (2,*)

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006,
(*) Corresponding Author

Received: 14 Sep 2010 | Revised: 09 May 2011 | Accepted: 05 Jan 2011 | Published: 30 Jun 2011 | Issue Date: June 2011

Abstract


A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method.

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Keywords


1-(1,4-Benzodioxane-2-carbonyl)piperazine; Antimicrobial activity; Antioxidant activity; Structure-activity relationship; Sulphonyl chlorides; Acid chlorides

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DOI: 10.5155/eurjchem.2.2.193-199.282

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University Grants Commission, New Delhi, India

Citations

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How to cite


Mallesha, L.; Mohana, K. Eur. J. Chem. 2011, 2(2), 193-199. doi:10.5155/eurjchem.2.2.193-199.282
Mallesha, L.; Mohana, K. Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives. Eur. J. Chem. 2011, 2(2), 193-199. doi:10.5155/eurjchem.2.2.193-199.282
Mallesha, L., & Mohana, K. (2011). Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives. European Journal of Chemistry, 2(2), 193-199. doi:10.5155/eurjchem.2.2.193-199.282
Mallesha, Lingappa, & Kikkeri Narasimhasetty Mohana. "Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives." European Journal of Chemistry [Online], 2.2 (2011): 193-199. Web. 30 May. 2023
Mallesha, Lingappa, AND Mohana, Kikkeri. "Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

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