European Journal of Chemistry

Synthesis, antimicrobial and antioxidant activities of 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives

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Published: Jun 30, 2011
DOI: https://doi.org/10.5155/eurjchem.2.2.193-199.282
Keywords:
1-(1, 4-Benzodioxane-2-carbonyl)piperazine, Antimicrobial activity, Antioxidant activity, Structure-activity relationship, Sulphonyl chlorides, Acid chlorides
Section
Research Article
Issue
Vol. 2 No. 2 (2011): June 2011
Dates
Received 2010-09-14
Accepted 2010-11-09
Published 2011-06-30


Main Article Content

Lingappa Mallesha
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India
Kikkeri Narasimhasetty Mohana
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006,

Abstract

A series of novel 1-(1,4-benzodioxane-2-carbonyl)piperazine derivatives (6a-h) and (7a-e) were synthesized by nucleophilic substitution reaction of 1-(1,4-benzodioxane-2-carbonyl)piperazine (3) with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, 1H NMR and LC-MS spectral studies. All compounds were evaluated for in vitro antibacterial, antifungal and antioxidant activities. Compound, 4-(2-trifluoromethyl)-benzenesulfonyl-1-(1,4-benzodioxane -2-carbonyl)piperazine (6b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains. Compound, 4-(3-methoxy)-benzoyl-1-(1,4-benzodioxane-2-carbonyl)piperazine (7a) showed moderate antioxidant activity compared to standard drug by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay method.

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Mallesha, L.; Mohana, K. N. Synthesis, Antimicrobial and Antioxidant Activities of 1-(1,4-Benzodioxane-2-carbonyl)piperazine Derivatives. Eur. J. Chem. 2011, 2, 193-199.

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