

Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives
Mohammed Shabaan (1)



(1) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(2) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(3) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(*) Corresponding Author
Received: 27 Sep 2010 | Revised: 01 May 2011 | Accepted: 24 Dec 2010 | Published: 30 Sep 2011 | Issue Date: September 2011
Abstract
New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration.
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DOI: 10.5155/eurjchem.2.3.365-371.289
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Citations
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[2]. Azza Taher Taher, Nadia Abdalla Khalil, Eman Mohamed Ahmed, Yasser Mohamed Ragab
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[3]. Asmaa S. Salman, Anhar Abdel-Aziem, Marwa J. S. Alkubbat
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[4]. Kapil Mohan Saini, Sonu Kumar, Monika Patel, Rakesh K. Saunthwal, Akhilesh K. Verma
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[5]. Lamia W. Mohamed, Azza T. Taher, Ghada S. Rady, Mamdouh M. Ali, Abeer E. Mahmoud
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DOI Link: https://doi.org/10.5155/eurjchem.2.3.365-371.289

















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