European Journal of Chemistry 2011, 2(3), 365-371 | doi: | Get rights and content

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Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives

Mohammed Shabaan (1) , Azza Taher Taher (2,*) , Eman Omar Osman (3)

(1) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(2) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(3) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(*) Corresponding Author

Received: 27 Sep 2010 | Revised: 01 May 2011 | Accepted: 24 Dec 2010 | Published: 30 Sep 2011 | Issue Date: September 2011


New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration.



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European Journal of Chemistry


Quinoxaline; 3,4-dihydroquinoxalin; Antimicrobial activity; CK1 inhibitors; CDK5 inhibitors; GSK-3β inhibitors

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DOI: 10.5155/eurjchem.2.3.365-371.289

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How to cite

Shabaan, M.; Taher, A.; Osman, E. Eur. J. Chem. 2011, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, M.; Taher, A.; Osman, E. Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives. Eur. J. Chem. 2011, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, M., Taher, A., & Osman, E. (2011). Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives. European Journal of Chemistry, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, Mohammed, Azza Taher Taher, & Eman Omar Osman. "Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives." European Journal of Chemistry [Online], 2.3 (2011): 365-371. Web. 30 May. 2023
Shabaan, Mohammed, Taher, Azza, AND Osman, Eman. "Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

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