European Journal of Chemistry 2011, 2(3), 365-371 | doi: https://doi.org/10.5155/eurjchem.2.3.365-371.289 | Get rights and content

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Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives


Mohammed Shabaan (1) , Azza Taher Taher (2,*) , Eman Omar Osman (3)

(1) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(2) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(3) Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(*) Corresponding Author

Received: 27 Sep 2010 | Revised: 01 May 2011 | Accepted: 24 Dec 2010 | Published: 30 Sep 2011 | Issue Date: September 2011

Abstract


New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration.

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Keywords


Quinoxaline; 3,4-dihydroquinoxalin; Antimicrobial activity; CK1 inhibitors; CDK5 inhibitors; GSK-3β inhibitors

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DOI: 10.5155/eurjchem.2.3.365-371.289

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[1]. Asmaa S. Salman, Naema A. Mahmoud, Anhar Abdel-Aziem, Mona A. Mohamed, Doaa M. Elsisi
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DOI: 10.4236/ijoc.2015.52010
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[2]. Azza Taher Taher, Nadia Abdalla Khalil, Eman Mohamed Ahmed, Yasser Mohamed Ragab
Synthesis of Certain 2-Substituted-1H-benzimidazole Derivatives as Antimicrobial and Cytotoxic Agents
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[3]. Asmaa S. Salman, Anhar Abdel-Aziem, Marwa J. S. Alkubbat
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International Journal of Organic Chemistry  05(01), 15, 2015
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[4]. Kapil Mohan Saini, Sonu Kumar, Monika Patel, Rakesh K. Saunthwal, Akhilesh K. Verma
Trifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines
European Journal of Organic Chemistry  2017(25), 3707, 2017
DOI: 10.1002/ejoc.201700541
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[5]. Lamia W. Mohamed, Azza T. Taher, Ghada S. Rady, Mamdouh M. Ali, Abeer E. Mahmoud
Synthesis and cytotoxic activity of certain benzothiazole derivatives against human MCF-7 cancer cell line
Chemical Biology & Drug Design  89(4), 566, 2017
DOI: 10.1111/cbdd.12879
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How to cite


Shabaan, M.; Taher, A.; Osman, E. Eur. J. Chem. 2011, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, M.; Taher, A.; Osman, E. Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives. Eur. J. Chem. 2011, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, M., Taher, A., & Osman, E. (2011). Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives. European Journal of Chemistry, 2(3), 365-371. doi:10.5155/eurjchem.2.3.365-371.289
Shabaan, Mohammed, Azza Taher Taher, & Eman Omar Osman. "Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives." European Journal of Chemistry [Online], 2.3 (2011): 365-371. Web. 30 May. 2023
Shabaan, Mohammed, Taher, Azza, AND Osman, Eman. "Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

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