European Journal of Chemistry

Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety

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Published: Sep 29, 2010
DOI: https://doi.org/10.5155/eurjchem.1.3.168-172.29
Keywords:
1, 2, 4-Triazine, 4-Triazole, Imidazole, Polyheterocyclic nitrogen systems, Antimicrobial activity
Section
Research Article
Issue
Vol. 1 No. 3 (2010): September 2010
Dates
Received 2010-04-01
Accepted 2010-07-15
Published 2010-09-29


Main Article Content

Wafaa Ramzy Abdel-Monem
Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, 11711, Egypt

Abstract

7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.

1_3_168_172_800


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Abdel-Monem, W. R. Synthesis and Antimicrobial Evaluation of Some New Polyheterocyclic Systems Containing 1,2,4-Triazine Moiety. Eur. J. Chem. 2010, 1, 168-172.

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