European Journal of Chemistry 2010, 1(3), 168-172 | doi: https://doi.org/10.5155/eurjchem.1.3.168-172.29 | Get rights and content

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Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety


Wafaa Ramzy Abdel-Monem (1,*)

(1) Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, 11711, Egypt
(*) Corresponding Author

Received: 01 Apr 2010 | Revised: 11 Jun 2010 | Accepted: 15 Jul 2010 | Published: 29 Sep 2010 | Issue Date: September 2010

Abstract


7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.

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Keywords


1,2,4-Triazine; 1,2,4-Triazole; Imidazole; Polyheterocyclic nitrogen systems; Antimicrobial activity

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DOI: 10.5155/eurjchem.1.3.168-172.29

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Funding information


Ain Shams University

Citations

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[2]. Wen-Bin Chen, Zhi-Xin Li, Xin-Wei Yu, Meng Yang, Yan-Xuan Qiu, Wen Dong
M2+ and Ln3+-catalyzed synthesis of a [1,2,4]triazine core via intramolecular C–H/N–H functionalization and C–N bond formation (M = Mn, Zn, Cd; Ln = Dy, Tb)
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DOI: 10.1039/C4NJ01027B
/

[3]. Ali Keivanloo, Saghi Sepehri, Mohammad Bakherad, Mahboobe Eskandari
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[4]. Sheikdawood Parveen, Thathan Premkumar, Hung-Huy Nguyen, Subbiah Govindarajan
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[5]. Sheikdawood Parveen, Thathan Premkumar, Hung Huy Nguyen, Subbiah Govindarajan
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DOI: 10.1039/C9NJ02377A
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[6]. M.S.T. Makki, R.M. Abdel-Rahman, M.S. El-Shahawi
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DOI: 10.1016/j.arabjc.2011.07.028
/

[7]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
Synthesis and Antimicrobial Activities of Some 6-Methyl-3-Thioxo-2,3-Dihydro-1,2,4-Triazine Derivatives
Phosphorus, Sulfur, and Silicon and the Related Elements  189(3), 400, 2014
DOI: 10.1080/10426507.2012.755972
/

[8]. Mukund Jha, Ozair Alam, Mohd. Javed Naim, Vrinda Sharma, Parth Bhatia, Aadil Ahmad Sheikh, Farah Nawaz, Perwaiz Alam, Ajay Manaithiya, Vivek Kumar, Shagufi Nazar, Nadeem Siddiqui
Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking
European Journal of Pharmaceutical Sciences  153, 105494, 2020
DOI: 10.1016/j.ejps.2020.105494
/

References


[1]. El-Gendy, Z.; Morsy, J. M.; Allimony, H. A; Abdel-Monem Ali, W. R.; Abdel-Rahman, R. M. Phosphorus, Sulfur Silicon Relat. Elem. 2003, 178(9), 2055-2071.
doi:10.1080/10426500390228738

[2]. Erickson, J. G. Chem. Heterocycl. Compd. 1956, 10, 44-51.
doi:10.1002/9780470186589.ch2

[3]. Jones, R. L.; Kershaw, J. R. Rev. Pure Appl. Chem. 1971, 21, 23-29.

[4]. Neunhoeffer, H.; Wiley, P. F. Chem. Heterocycl. Compd. 1978, 33, 189-196.
doi:10.1002/9780470187050.ch10

[5]. El Ashry, E. H.; Rashed, M.; Taha, E.; Ramadan, E. Adv. Heterocycl. Chem. 1994, 59, 39-46.
doi:10.1016/S0065-2725(08)60007-0

[6]. Abdel-Rahman, R. M. Pharmazie 2001, 56, 275-281.
PMid:11338663

[7]. El-Gendy, Z.; Morsy, J. M.; Allimony, H. M.; Abdel-Monem Ali, W. R.; Abdel-Rahman, R. M. Pharmazie 2001, 56, 376-381.
PMid:11400552

[8]. Hunt, J. T.; Mitt, T.; Borzilleri, R.; Brown, J.; Fink, B.; Bhide. J. Med. Chem. 2007, 47, 4054-4059.
doi:10.1021/jm049892u
PMid:15267243

[9]. Sztanke, K.; Rzmowska, J.; Niemczyk, M.; Dybala, I.; Koizoi, A. Eur. Med. Chem. 2006, 41, 1373-1379.
doi:10.1016/j.ejmech.2006.06.013
PMid:16996655

[10]. Sarvesh Kumar, P.; Abhishek, F.; Ashutash, S.; Nizamuddin, S. J. Eur. Med. Chem. 2009, 44, 1188-1196.
doi:10.1016/j.ejmech.2008.05.033
PMid:18614258

[11]. Deeb, A.; El-Mariah, F.; Hosny, M. A. Bioorg. Med. Chem. Lett. 2004, 14, 5013-5017.
doi:10.1016/j.bmcl.2004.06.102

[12]. Cai, S.; Li, Q. S.; Borchardt, R. T.; Kuczera, K.; Schowen, R. L. Bioorg. Med. Chem. 2007, 15, 7281-7287.
doi:10.1016/j.bmc.2007.08.029

[13]. Demirbas, A.; Ceylan, S.; Demirbas, N. J. Heterocycl. Chem. 2007, 44, 1271-1280.
doi:10.1002/jhet.5570440608

[14]. Gewald, K. G.; Schnbelt, A.; Martin, G. J. Prakt. Chem. 1975, 317, 561-569.
doi:10.1002/prac.19753170407

[15]. Al-Omran, F.; Abdel Khalik M.; Elna, M. H. J. Heterocycl. Chem. 1995, 6, 545-564.

[16]. Abdel-Monem, W. R. Chem. Pap. 2004, 276-282.

[17]. Abdel-Monem, W. R. Boll. Chim. Farmaco, 2004, 143(6), 239-247.
PMid:15881802

[18]. Abdel-Monem, W. R. Boll. Chim. Farmaco, 2005, 144(5), 1-23.

[19]. Abdel-Monem, W. R.; Ali, T. E. Int. J. Chem., 2007, 17, 303-314.

[20]. Al-Najjar, A. A. A.; Amer, S. A.; Riad, M.; Elghamy, I.; M. H. Elnagdy, M. H. J. Chem. Research (S), 1996, 296-297.

[21]. Gould, J. C.; Bowi, J. M. J. Eur. Med. Chem.1952, 59, 198-205.

[22]. Singh, A.; Latita, R.; R. Dhakareg, R.; Saxena, G. C. J. Indian Chem. Soc. 1996, 73, 339-348.

[23]. Chaudhaxy, A.; Singh, R. V. Phosphorus, Sulfur Silicon Relat. Elem. 2003, 178, 603-609.
doi:10.1080/10426500307927

[24]. Saraswati, S.; Utpal, D.; Parikh, A. R. J. Indian Chem. Soc., 1994, 71, 159-167.


How to cite


Abdel-Monem, W. Eur. J. Chem. 2010, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, W. Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety. Eur. J. Chem. 2010, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, W. (2010). Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety. European Journal of Chemistry, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, Wafaa. "Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety." European Journal of Chemistry [Online], 1.3 (2010): 168-172. Web. 11 Dec. 2023
Abdel-Monem, Wafaa. "Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety" European Journal of Chemistry [Online], Volume 1 Number 3 (29 September 2010)

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