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Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety
Wafaa Ramzy Abdel-Monem (1,*)
(1) Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, 11711, Egypt
(*) Corresponding Author
Received: 01 Apr 2010 | Revised: 11 Jun 2010 | Accepted: 15 Jul 2010 | Published: 29 Sep 2010 | Issue Date: September 2010
Abstract
7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.1.3.168-172.29
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Ain Shams University
Citations
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[2]. Wen-Bin Chen, Zhi-Xin Li, Xin-Wei Yu, Meng Yang, Yan-Xuan Qiu, Wen Dong
M2+ and Ln3+-catalyzed synthesis of a [1,2,4]triazine core via intramolecular C–H/N–H functionalization and C–N bond formation (M = Mn, Zn, Cd; Ln = Dy, Tb)
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[3]. Ali Keivanloo, Saghi Sepehri, Mohammad Bakherad, Mahboobe Eskandari
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[4]. Sheikdawood Parveen, Thathan Premkumar, Hung-Huy Nguyen, Subbiah Govindarajan
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[7]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
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DOI Link: https://doi.org/10.5155/eurjchem.1.3.168-172.29
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European Journal of Chemistry 2010, 1(3), 168-172 | doi: https://doi.org/10.5155/eurjchem.1.3.168-172.29 | Get rights and content
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