European Journal of Chemistry 2010, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29

Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety


Wafaa Ramzy Abdel-Monem (1,*)

(1) Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, 11711, Egypt
(*) Corresponding Author

Received: 01 Apr 2010, Accepted: 15 Jul 2010, Published: 29 Sep 2010

Abstract


7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.

1_3_168_172_800


Keywords


1,2,4-Triazine; 1,2,4-Triazole; Imidazole; Polyheterocyclic nitrogen systems; Antimicrobial activity

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DOI: 10.5155/eurjchem.1.3.168-172.29

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[1]. Magdy A. Ibrahim, Nasser M. El-Gohary
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[2]. Wen-Bin Chen, Zhi-Xin Li, Xin-Wei Yu, Meng Yang, Yan-Xuan Qiu, Wen Dong
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[4]. M.S.T. Makki, R.M. Abdel-Rahman, M.S. El-Shahawi
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[5]. Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
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How to cite


Abdel-Monem, W. Eur. J. Chem. 2010, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, W. Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety. Eur. J. Chem. 2010, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, W. (2010). Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety. European Journal of Chemistry, 1(3), 168-172. doi:10.5155/eurjchem.1.3.168-172.29
Abdel-Monem, Wafaa. "Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety." European Journal of Chemistry [Online], 1.3 (2010): 168-172. Web. 23 Oct. 2019
Abdel-Monem, Wafaa. "Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety" European Journal of Chemistry [Online], Volume 1 Number 3 (29 September 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.3.168-172.29

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