European Journal of Chemistry 2012, 3(1), 1-9 | doi: https://doi.org/10.5155/eurjchem.3.1.1-9.492 | Get rights and content

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Synthesis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines


Svetlana Mikhaylichenko (1,*) , Anthony Veloso (2) , Kunjal Patel (3) , Vladimir Zaplishny (4)

(1) Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, M1C 1A4, ON, Canada
(2) Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, M1C 1A4, ON, Canada
(3) Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, M1C 1A4, ON, Canada
(4) Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, M1C 1A4, ON, Canada
(*) Corresponding Author

Received: 22 Jul 2011 | Revised: 18 Oct 2011 | Accepted: 19 Oct 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract


The reaction between monoazido derivatives of 1,3,5-triazine and CH-active carbonyl compounds were studied in order to obtain novel coupled heterocyclic systems with potential bioactivity. Reaction conditions were varied and optimized, a series 2,4-disubstituted derivatives of 6-(1H-1,2,3-triazol-1-yl)-1,3,5-triazines were obtained with good yield.

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Keywords


Cyclization; Synthesis; Structure; 1,3,5-triazines; 2-Azido-4,6-disubstituted-1,3,5-triazines; 1,2,3-Triazolyl substituted 1,3,5-triazines

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DOI: 10.5155/eurjchem.3.1.1-9.492

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Funding information


Department of Physical and Environmental Sciences of the University of Toronto Scarborough, Toronto, M1C 1A4, ON, Canadaa

Citations

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[1]. Shibo Xie, Ziqiang Yan, Yuanheng Li, Qun Song, Mingming Ma
Intrinsically Safe and Shelf-Stable Diazo-Transfer Reagent for Fast Synthesis of Diazo Compounds
The Journal of Organic Chemistry  83(18), 10916, 2018
DOI: 10.1021/acs.joc.8b01587
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Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Mikhaylichenko, S.; Veloso, A.; Patel, K.; Zaplishny, V. Eur. J. Chem. 2012, 3(1), 1-9. doi:10.5155/eurjchem.3.1.1-9.492
Mikhaylichenko, S.; Veloso, A.; Patel, K.; Zaplishny, V. Synthesis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines. Eur. J. Chem. 2012, 3(1), 1-9. doi:10.5155/eurjchem.3.1.1-9.492
Mikhaylichenko, S., Veloso, A., Patel, K., & Zaplishny, V. (2012). Synthesis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines. European Journal of Chemistry, 3(1), 1-9. doi:10.5155/eurjchem.3.1.1-9.492
Mikhaylichenko, Svetlana, Anthony Veloso, Kunjal Patel, & Vladimir Zaplishny. "Synthesis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines." European Journal of Chemistry [Online], 3.1 (2012): 1-9. Web. 22 Jan. 2021
Mikhaylichenko, Svetlana, Veloso, Anthony, Patel, Kunjal, AND Zaplishny, Vladimir. "Synthesis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

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