European Journal of Chemistry

Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents



Main Article Content

Ahmed El-Ziaty
Abdelaal Abdalh
Ashraf Hamed
Sayed Shiba
Abdelhafed Abdullha

Abstract

Compound, 2-cyano-3-(2ˊ,4ˊ-dichlorophenyl)-2-prpoenoyl chloride, 3, was reacted with nitrogen, sulfur, and oxygen nucleophilic reagents to give new 2-propenoyl amide and ester derivatives. Some of these derivatives were cyclized under the reaction conditions and/or with POCl3 or Ac2O to give new derivatives of heterocyclic systems. Some of these compounds were tested as antibacterial and antifungal agents.

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El-Ziaty, A.; Abdalh, A.; Hamed, A.; Shiba, S.; Abdullha, A. Synthesis of Novel 2-Propenoyl Amides, Esters, Heterocyclic Compounds and Their Screening As Antifungal and Antibacterial Agents. Eur. J. Chem. 2012, 3, 65-70.

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Micro Analytical Center, Cairo University, Egypt
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