European Journal of Chemistry

Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents

Main Article Content

Ahmed El-Ziaty
Abdelaal Abdalh
Ashraf Hamed
Sayed Shiba
Abdelhafed Abdullha


Compound, 2-cyano-3-(2ˊ,4ˊ-dichlorophenyl)-2-prpoenoyl chloride, 3, was reacted with nitrogen, sulfur, and oxygen nucleophilic reagents to give new 2-propenoyl amide and ester derivatives. Some of these derivatives were cyclized under the reaction conditions and/or with POCl3 or Ac2O to give new derivatives of heterocyclic systems. Some of these compounds were tested as antibacterial and antifungal agents.


icon graph This Abstract was viewed 1888 times | icon graph Article PDF downloaded 822 times

How to Cite
El-Ziaty, A.; Abdalh, A.; Hamed, A.; Shiba, S.; Abdullha, A. Synthesis of Novel 2-Propenoyl Amides, Esters, Heterocyclic Compounds and Their Screening As Antifungal and Antibacterial Agents. Eur. J. Chem. 2012, 3, 65-70.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Santos, S. A.; Pereira, N. Jr.; Da Silva, I. M.; Sarquis, M. I. M; Antunes, O. A. C. Process Biochem. 2004, 39, 2269-2275.

[2]. Li, Y. L.; Xu, W. F. Bioorg. Med. Chem. 2004, 13, 5171-5180.

[3]. Sousa, J. B.; Calheiros, R.; Rio, V.; Borges, F.; Marques, M. P. M. J. Mol. Struct. 2006, 783, 122-128.

[4]. Schwaiger, S.; Cervellati, R.; Seger, C.; Ellmerer, E. P.; About, N.; Renimel, I.; Godenir, C.; Andre, P.; Gafner, F.; Stuppner, H.; Tetrahedron 2005, 61(19), 4621-4630.

[5]. Rehman, S. U.; Shahid, K.; Ali, S.; Bhatti, M. H.; Parvez, M. J. Organomet. Chem. 2005, 690(5), 1396-1408.

[6]. Grayer, R. J.; Eckert, M. R.; Veitch, N. C.; Kite, G. C.; Marin, P. D.; Kokubun, T.; Simmonds, M. S. J.; Paton, A. J. Phytochemistry 2003, 64(2), 519-528.

[7]. Sondhi, S. M.; Singh, N.; Kumar, A.; Lozach, O.; MeiJer L. Bioorg. Med. Chem. 2006, 14(11), 3758-3765.

[8]. Zhao, L.; Tao, K.; Li, H.; Zhang, J. Tetrahedron 2011, 67(15), 2803-2806.

[9]. Eric, A.; Alexander, Y.; Kots, B.; Ferid, M.; Scott, R. Bioorg. Med. Chem. Lett. 2009, 19(11), 3067-3071.

[10]. Fumiko, M.; Michinao, H.; Sorasaree, T.; Kenichi, Y.; David, A. Tetrahedron 2010, 66(26), 4888-4893.

[11]. Wu, C. C.; Wang, T. W.; Wang, W. Y.; Hsich, P. W.; Wu, Y. C. Eur. J. Pharmacol. 2005, 527(1-3), 37-43.

[12]. Gallegos, A.; Carbo-Dorca, R.; Ponec, R.; Waisser, K. Inter. J. Pharma. 2004, 269(1), 51-60.

[13]. Palmer, J. T.; Hirschbein, B. L.; Cheung, H.; McCarter, J.; Janc, J. W.; Yu, Z. W.; Wesolowski, G. Bioorg. Med. Chem. Lett. 2006, 16(11), 2909-2914.

[14]. Musad, E. A.; Mohamed, R.; Saeed, B. A.; Vishwanath, B. S.; Rai, K. M. L. Bioorg. Med. Chem. Lett. 2011, 21(12), 3536-3540.

[15]. Jing, Z. L.; Zhang, Q. Z.; Yu, M.; Chen, X. Acta Crystallogr. E 2006, 62(10), o4489-o4490.

[16]. Grayer, R. J.; Harbone, J. B.; Survery, A. Phytochemistry 1994, 37, 19-42.

[17]. Irob, O. N.; Moo-Young, M.; Anderson, W. A. Int. J. Pharm. 1996, 34, 87-90.

[18]. Jawetz, E.; Melnick, J. I.; Adelberg, E. A. Review of Medical Microbiology, Lang Medical Publication, Los Altos, California, 1974.

[19]. Muanza, D. N.; Kim, B. W.; Euler, K. L.; Williams, L. Zaire. Internat. J. Pharmacog. 1994, 32, 337-345.

[20]. Madkour, H. M. F.; Shiba, S. A.; Sayed, H. M.; Hamed A. A. Suflur Lett. 2001, 24, 151- 179.

[21]. El-Ziaty, A. K.; Shiba, S. A. Synth. Commun. 2007, 37, 4043-4057.

[22]. Shiba, S. A.; El-Ziaty, A. K.; El-Aasar, N. K.; Al-Saman, H. A. J. Chem. Res. 2008, 9, 500-506.

[23]. Shiba, S. A.; El-Ziaty, A. K.; El-Aaser, N. K.; Al-Saman, H. A. Phosphorus Sulfur 2010, 185(8), 1645-1657.

[24]. Schiemenz, G. P.; Engelhard, M. Chem. Ber. 1962, 95, 976-970.

[25]. Chen, Y.; Wehrmann, R.; Koehler, B. Ger. Offen. DE 19, 505, 940(Cl. C07D311/16), 22 Aug 1996, [C. A. 1996, 125, 221585w].

Supporting Agencies

Micro Analytical Center, Cairo University, Egypt
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).