European Journal of Chemistry

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines

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Published: Dec 31, 2011
DOI: https://doi.org/10.5155/eurjchem.2.4.539-543.55
Keywords:
Mass spectroscopy, Phosphorylation, Triphenylphosphine, Schiff bases, X-ray crystallography, Antimicrobial activity
Section
Research Article
Issue
Vol. 2 No. 4 (2011): December 2011
Dates
Received 2010-04-11
Accepted 2010-06-05
Published 2011-12-31


Main Article Content

Emtithal Ahmed El-Sawi
Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
Tahia Bayoumy Mostafa
Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
Hyam Ali Radwan
Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt

Abstract

Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.

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El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Synthesis and Biological Activity of Functionalized Phosphorus Derivatives of Isatin Imines. Eur. J. Chem. 2011, 2, 539-543.

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