European Journal of Chemistry

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines



Main Article Content

Emtithal Ahmed El-Sawi
Tahia Bayoumy Mostafa
Hyam Ali Radwan

Abstract

Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.

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El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Synthesis and Biological Activity of Functionalized Phosphorus Derivatives of Isatin Imines. Eur. J. Chem. 2011, 2, 539-543.

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