

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines
Emtithal Ahmed El-Sawi (1,*)



(1) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(2) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(3) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(*) Corresponding Author
Received: 11 Apr 2010 | Revised: 07 May 2010 | Accepted: 05 Jun 2010 | Published: 31 Dec 2011 | Issue Date: December 2011
Abstract
Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.
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DOI: 10.5155/eurjchem.2.4.539-543.55
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Citations
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Asymmetric Vinylogous Mannich Reaction of Silyloxy Furans with N-tert-Butanesulfinyl Ketimines
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DOI: 10.1021/ol4037117

[2]. Pedro Henrique do Nascimento Pereira, Jackelinne Camargo Lima, Victor Marcelo Deflon, Geoffroy Roger Pointer Malpass, Ronaldo Junio De Oliveira, Pedro Ivo Da Silva Maia
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DOI: 10.5155/eurjchem.12.3.235-241.2106

[3]. Mona Hizkial Nasr Arsanious, Soher Said Maigali
Isatin Imines in the Reaction with Iminophosphine: X-Ray Structure of Phospholane Derivatives
Synthetic Communications 44(2), 202, 2014
DOI: 10.1080/00397911.2013.800210

[4]. Ivan Hameed Rouil Tomi, Amer Hasan Abdullah, Ali Hussein Raheemah Al-Daraji, Selma Abdul Rudha Abbass
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[5]. Muhammad Islam, Zahid Shafiq, Mazhar Hussain, Hafiz Badaruddin Ahmad, Muhammad Ajaz Hussain
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DOI: 10.5155/eurjchem.6.4.417-421.1310

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