European Journal of Chemistry

Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones

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Mohamed Abdel Megid Abdel-Hamid
Azza Mohamed Elkazak
Magdy Hamed Sead
Osama Farouk Mohamed


Some novel pyrazolylfuropyrimidinethiones were synthesized from cyclocondensation of 4-hydrazino-5,6-diphenylfuro [2,3-d] pyrimidine-2(1H)-thione (3) with different enaminones and 1,3-dicarbonyl compounds. Whereas the furotriazolo-pyrimidinethiones were synthesized from reaction of compound 3 with benzoyl chloride, p-chlorobenzaldehyde and carbon disulphide. Furthermore, furotetrazolo-pyrimidinethione and ditetrazolofuro pyrimidine were synthesized.


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Abdel-Hamid, M. A. M.; Elkazak, A. M.; Sead, M. H.; Mohamed, O. F. Synthesis of Some New Pyrazolylfuropyrimidinethiones and Triazolofuropyrimidinethiones. Eur. J. Chem. 2012, 3, 273-278.

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[1]. Pang, W.; Zhu, S.; Xin, Y.; Jiang, H.; Zhu, Z. Tetrahedron 2010, 66, 1261-1266.

[2]. Abdel-Megid, M.; Elkazak, A. M.; Seada, M.; Farouk, O. S. J. Appl. Sci. Res. 2010, 6 (12), 2133-2138.

[3]. Maedo, Y.; Nakano, M.; Sato, H.; Migazak, Y.; Schweiker, S. L.; Smith, J. L.; Truesdale, A. T. Bioorg. Med. Chem. Lett. 2004, 14, 3907-3911.

[4]. Bhuiyan, M. M. H.; Rahman, K. M. M.; Hossain, M. K.; Rahim, M. A.; Hossain, M. I. Croat. Chem Acta. 2005, 78, 633-636.

[5]. Gangjee, A.; Zeng, Y.; McGuire, J. J.; Kisliuk, R. L. J. Med. Chem. 2005, 48, 5329-5336.
PMid:16078850 PMCid:2538949

[6]. Dave, C. G.; Shah, R. D. Molecules 2002, 7, 554-565.

[7]. Gangjee, A.; Zeng, Y.; Ihnat, M.; Warnke, L. A.; Green, D. W.; Kisliuk, R. L.; Lin, F. T. Bioorg. Med. Chem. 2005, 13, 5475-5491.

[8]. Janeba, Z.; Balzarini, J.; Andrei, G.; Snoeck, R.; De Clercq, E.; Robins M. J. J. Med. Chem. 2005, 48, 4690-4696.

[9]. Robins, M. J.; Miranda, K.; Rajwanshi, V. K.; Peterson, M. A.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. J. J. Med. Chem. 2006, 49, 391-398.

[10]. Abdel-Megid, M. J. Synth. Commun. 2007, 37, 3211-3218.

[11]. Abdel-Megid, M. Pharmazie 2000, 55, 263-268.

[12]. Abdel-Megid, M.; Abbas, M.; Hassan, M. J. Heterocycl. Chem. 2007, 44, 315-322.

[13]. Ali, T. E. Eur. J. Med. Chem. 2009, 44, 4385-4392.

[14]. Behalo, M. S. Phosphorus Sulfur 2009, 184 (14), 206-219.

[15]. Abu-Zied, K. H. Phosphorus Sulfur 2007, 182 (28), 447-474.

[16]. Hussein, A. H. M.; El-Gaby, M. S.; Abu-Shanab, F.; Abdel-Raheim, A. M. Org. Commun. 2009, 2(3), 66-71.

[17]. Gewald, K. Chem. Ber. 1966, 99, 1002-1007.

[18]. Korbukh, I. A.; Bulychev, Y. N.; Preobrazhenskaya, M. N. Chem. Heterocyc. Compd. 1979, 15 (12), 1361-1366.

[19]. Kmetic, M.; Stanovnik, B. J. Heterocycl. Chem. 1995, 32, 1563-1565.

[20]. Abdel-Megid, M. Chem. Heterocycl. Compd. 2010, 3, 405-414.

[21]. Abdel-Megid, M. Internat. J. Chem. 2006, 16 (3), 149-15

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