European Journal of Chemistry 2012, 3(3), 273-278 | doi: https://doi.org/10.5155/eurjchem.3.3.273-278.605 | Get rights and content






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Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones


Mohamed Abdel Megid Abdel-Hamid (1) , Azza Mohamed Elkazak (2,*) , Magdy Hamed Sead (3) , Osama Farouk Mohamed (4)

(1) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(2) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(3) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(4) Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt
(*) Corresponding Author

Received: 29 Feb 2012 | Revised: 05 Apr 2012 | Accepted: 15 Apr 2012 | Published: 30 Sep 2012 | Issue Date: September 2012

Abstract


Some novel pyrazolylfuropyrimidinethiones were synthesized from cyclocondensation of 4-hydrazino-5,6-diphenylfuro [2,3-d] pyrimidine-2(1H)-thione (3) with different enaminones and 1,3-dicarbonyl compounds. Whereas the furotriazolo-pyrimidinethiones were synthesized from reaction of compound 3 with benzoyl chloride, p-chlorobenzaldehyde and carbon disulphide. Furthermore, furotetrazolo-pyrimidinethione and ditetrazolofuro pyrimidine were synthesized.

3_3_273_278_800


Keywords


Triazoles; Pyrazoles; Tetrazoles; Enaminones; Ditetrazoles; Furopyrimidines

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DOI: 10.5155/eurjchem.3.3.273-278.605

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[1]. Krishna Bahadur Somai Magar, Yong Rok Lee, Sung Hong Kim
Efficient one-pot synthesis of novel and diverse furo[2,3- $$d$$ d ]pyrimidinediones and thioxofuro[2,3- $$d$$ d ]pyrimidineones by the rhodium (II) pivalate-catalyzed reactions of cyclic diazo compounds
Molecular Diversity  17(4), 679, 2013
DOI: 10.1007/s11030-013-9463-9
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[2]. Mohamed Ahmed Mahmoud Abdel Reheim, Ibrahim Saad Abdel Hafiz, Safaa Mohamed
Utility of β-diketones in heterocyclic synthesis: Synthesis of new tetrahydro-pyrimidinethione, pyrazole, thiophene, dihydropyridine, dihydropyrane, pyridazine derivatives and investigation of their antimicrobial activity
European Journal of Chemistry  7(3), 298, 2016
DOI: 10.5155/eurjchem.7.3.298-308.1447
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[3]. Azza M. El-Kazak, Magdy A. Ibrahim
Synthesis, Characterization, and Antimicrobial Evaluation of the Novel Triazolotriazolopyridines and Pyridotriazolotriazines
Journal of Heterocyclic Chemistry  54(2), 1604, 2017
DOI: 10.1002/jhet.2749
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How to cite


Abdel-Hamid, M.; Elkazak, A.; Sead, M.; Mohamed, O. Eur. J. Chem. 2012, 3(3), 273-278. doi:10.5155/eurjchem.3.3.273-278.605
Abdel-Hamid, M.; Elkazak, A.; Sead, M.; Mohamed, O. Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones. Eur. J. Chem. 2012, 3(3), 273-278. doi:10.5155/eurjchem.3.3.273-278.605
Abdel-Hamid, M., Elkazak, A., Sead, M., & Mohamed, O. (2012). Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones. European Journal of Chemistry, 3(3), 273-278. doi:10.5155/eurjchem.3.3.273-278.605
Abdel-Hamid, Mohamed, Azza Mohamed Elkazak, Magdy Hamed Sead, & Osama Farouk Mohamed. "Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones." European Journal of Chemistry [Online], 3.3 (2012): 273-278. Web. 8 Jul. 2020
Abdel-Hamid, Mohamed, Elkazak, Azza, Sead, Magdy, AND Mohamed, Osama. "Synthesis of some new pyrazolylfuropyrimidinethiones and triazolofuropyrimidinethiones" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

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DOI Link: https://doi.org/10.5155/eurjchem.3.3.273-278.605

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