European Journal of Chemistry 2012, 3(3), 293-297 | doi: https://doi.org/10.5155/eurjchem.3.3.293-297.613 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents


Shashidhar Kerur (1,*) , Kallanagouda Alagawadi (2) , Hailiang Zhu (3) , Fakkirappa Manvi (4)

(1) Department of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Belgaum, 580010, India
(2) Department of Pharmaceutics, Karnataka Lingayath Education University College of Pharmacy, Hubli, 580031, India
(3) State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China
(4) Department of Pharmaceutics, Karnataka Lingayath Education University College of Pharmacy, Hubli, 580031, India
(*) Corresponding Author

Received: 13 Apr 2012 | Accepted: 25 Jun 2012 | Published: 30 Sep 2012 | Issue Date: September 2012

Abstract


In the present study, synthesis and antimicrobial activity of 2,5-disubstituted 1,3,4-thiadiazole derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms.

3_3_293_297_800


Announcements


Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.

1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).

2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).

3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).


Editor-in-Chief
European Journal of Chemistry

Keywords


1,3,4-Thiadiazole; Phenacyl bromide; Molecular docking; Antimicrobial activity; Antitubercular activity; Mycobacterium tuberculosis

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.3.3.293-297.613

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1516 times | icon graph PDF Article downloaded 1092 times


Citations

/


[1]. Mahmoud R. Mahmoud, Manal M. El‐Shahawi, Fatma S. Abu El‐Azm, Mohamed Abdeen
Synthesis and Antimicrobial Activity of Polyfunctionally Substituted Heterocyclic Compounds Derived from 5‐Cinnamoylamino‐2‐Cyanomethyl‐1,3,4‐Thiadiazole
Journal of Heterocyclic Chemistry  54(4), 2352, 2017
DOI: 10.1002/jhet.2824
/


[2]. Parminder Kaur, Vimal Arora
Significance of Molecular Docking in Developing Potent Antimicrobial 1,3,4-Thiadiazole Derivatives
Letters in Organic Chemistry  20(5), 423, 2023
DOI: 10.2174/1570178619666220930144853
/


References


[1]. Soumya, S. Indian J. Tub. 2002, 49, 11-16.

[2]. Jolly, V. S.; Pathak, M. Indian J. Chem. 1993, 32B, 502-505.

[3]. Christensen, C. E.; Kragelund, B. B.; Von, P. W. K.; Henriksen, A. Protein Sci. 2007, 16, 261-267.
http://dx.doi.org/10.1110/ps.062473707
PMid:17242430 PMCid:2203288

[4]. De Jong, B. C.; Israelski, D. M.; Corbett, E. L.; Small, P. M. Annu. Rev. Med. 2004, 55, 280-304.
http://dx.doi.org/10.1146/annurev.med.55.091902.103753
PMid:14746522

[5]. Kemal, S.; Yasemin, U.; Mustafa, E. R. Turk. J. Chem. 2007, 31, 125-134.

[6]. Foroumadi, A. S.; Sharifzades, Z.; Hemmateenejod, B.; Moshafi, M. H. DARU 2007, 15, 218-226.

[7]. Sanmati, K. J.; Mishra, P. Indian J. Chem. 2004, 43B, 184-188.

[8]. Onkol, T.; Cakir, B.; Sahin, M. F.; Yildirim, E.; Ekol, K. Turk. J. Chem. 2004, 28, 461-468.

[9]. Fang, L.; Xiao-Qiong, L.; Pinaki, S.; Song, Y. Bioorg. Med. Chem. 2008, 16, 3632-3640.
http://dx.doi.org/10.1016/j.bmc.2008.02.006

[10]. Khalid, M.K.; Naheed, F.; Maimona, R.; Saima, J.; Shahnaz, P. M. Bioorg. Med. Chem. 2009, 12, 481- 486.

[11]. Padmavati, V.; Sudhakar, R. G.; Padmaja, A. Eur. J. Med. Chem. 2009, 44, 2106-2112.
http://dx.doi.org/10.1016/j.ejmech.2008.10.012
PMid:19036476

[12]. Kumar, N. D.; Kumar, N. M.; Kuei-Hua, C.; Kavita, S. Eur. J. Med. Chem. 2010, 45, 4664-4668.
http://dx.doi.org/10.1016/j.ejmech.2010.07.023
PMid:20692741

[13]. Talwar, M. B.; Desai, S, S.; Bennur, S, C. Indian J. Hetero. Chem. 1996, 5, 237-241.

[14]. Bhaskar, D.; Rajesh, H. D. Tetrahedron. Lett. 1996, 37(35), 6375-6378.
http://dx.doi.org/10.1016/0040-4039(96)01351-2

[15]. Joshi, S. D.; Vagdevi, H. M.; Vaidya, V. P.; Gadaginamath, G. S. Eur. J. Med. Chem. 2008, 43, 1989-1996.
http://dx.doi.org/10.1016/j.ejmech.2007.11.016
PMid:18207286

[16]. Stefania-Felicia, B.; Gabriela, L. A.; Ioanna, S.; Constantin, D.; Ana, I. T.; Gabriela, B. Eur. J. Med. Chem. 2009, 44, 4752-4757.
http://dx.doi.org/10.1016/j.ejmech.2009.06.021
PMid:19616347

[17]. Pattan, S. R.; Reddy, V. V. K.; Manvi, F. V.; Desai, B. G., Bhat, A. R. Indian J. Hetero. Chem. 2006, 45(B), 1778-1781.

[18]. Bauer, R. W.; Kirby, M. D. K.; Sherris, J. C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493-496.
PMid:5325707

[19]. Paul, M. K.; Mukhopadhyay. A. K. Int. J. Med. Sci. 2004, 1, 101-106.
http://dx.doi.org/10.7150/ijms.1.101
PMid:15912202 PMCid:1074718

[20]. Morris, G. M.; Goodsell, D. S.; Halliday, R. S.; Huey, R.; Hart, W. E.; Belew, R. K.; Olson. A. J. J. Comput. Chem. 1998, 19, 1639-1642.
http://dx.doi.org/10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B


How to cite


Kerur, S.; Alagawadi, K.; Zhu, H.; Manvi, F. Eur. J. Chem. 2012, 3(3), 293-297. doi:10.5155/eurjchem.3.3.293-297.613
Kerur, S.; Alagawadi, K.; Zhu, H.; Manvi, F. Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents. Eur. J. Chem. 2012, 3(3), 293-297. doi:10.5155/eurjchem.3.3.293-297.613
Kerur, S., Alagawadi, K., Zhu, H., & Manvi, F. (2012). Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents. European Journal of Chemistry, 3(3), 293-297. doi:10.5155/eurjchem.3.3.293-297.613
Kerur, Shashidhar, Kallanagouda Alagawadi, Hailiang Zhu, & Fakkirappa Manvi. "Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents." European Journal of Chemistry [Online], 3.3 (2012): 293-297. Web. 10 Dec. 2023
Kerur, Shashidhar, Alagawadi, Kallanagouda, Zhu, Hailiang, AND Manvi, Fakkirappa. "Synthesis, characterization and molecular docking studies of novel S-substituted phenacyl-1,3,4-thiadiazole-thiol derivatives as antimicrobial agents" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.3.3.293-297.613


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2012, 3(3), 293-297 | doi: https://doi.org/10.5155/eurjchem.3.3.293-297.613 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.