

Anticancer activity studies of some cyclic benzimidazole derivatives
Ali El-Shekeil (1,*)



(1) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(2) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(3) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(*) Corresponding Author
Received: 23 Apr 2012 | Accepted: 17 Jun 2012 | Published: 30 Sep 2012 | Issue Date: September 2012
Abstract
New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.3.356-358.621
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Sana’a University, Sana’a, Yemen
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DOI Link: https://doi.org/10.5155/eurjchem.3.3.356-358.621

















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