European Journal of Chemistry

Anticancer activity studies of some cyclic benzimidazole derivatives



Main Article Content

Ali El-Shekeil
Abeer Omer Obeid
Sama Al-Aghbari

Abstract

New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.

3_3_356_358_800


icon graph This Abstract was viewed 2847 times | icon graph Article PDF downloaded 958 times

How to Cite
(1)
El-Shekeil, A.; Obeid, A. O.; Al-Aghbari, S. Anticancer Activity Studies of Some Cyclic Benzimidazole Derivatives. Eur. J. Chem. 2012, 3, 356-358.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Ramla, M. M.; Omer, M. A.; El-Khamry, A. M. M.; El-Diwani, H. I. Bioorg. Med. Chem. 2006, 14, 7324-7332.
http://dx.doi.org/10.1016/j.bmc.2006.06.033

[2]. Yang, Y. H.; Cheng, M. S.; Wang, Q. H.; Nie, H.; Liao, N.; Wang, J.; Chen, H.; Design. Eur. J. Med. Chem. 2009, 44, 1808-1812.
http://dx.doi.org/10.1016/j.ejmech.2008.07.021
PMid:18762358

[3]. Penning, T. D.; Zhu, G. D.; Gandhi, V. B.; Gong Thomas, S. J.; Lubisch, W.; Gradel, R.; Wernet, W.; Park, C. H.; Fry, E. H.; Liu X.; Shi, Y.; Klinghofer, V.; Johnson, E. F.; Donawho, C. K.; Frost, D. J.; Diaz, V. B.; Bouska, J. J.; Olson, A. M.; Marsh, K. C. Bioorg. Med. Chem. 2008, 16, 6965-6975.
http://dx.doi.org/10.1016/j.bmc.2008.05.044

[4]. Garuti, L.; Roberti, M.; Pizzirani, D.; Pession A.; Leoncini, E.; Cenci, V.; Hrelia, S. Il Farmaco 2004, 59, 663-668.
http://dx.doi.org/10.1016/j.farmac.2004.04.001
PMid:15262537

[5]. Spasov, A. R.; Iezhitsa, I. N.; Bugaeva, L. I.; Anisimova, V. A. Khim. Farm. Zh. 1999, 33, 6-12.

[6]. Parshanth, A.; David, W. W. J. Am. Chem. Soc. 2009, 131, 7618-7624.
http://dx.doi.org/10.1021/ja809249h
PMid:19445463 PMCid:2698132

[7]. Klimesova, V.; Koci, J.; Pour, M.; Stachel, J.; Waisser, K.; Kaustova, J. Eur. J. Med. Chem. 2002, 37, 409-420.
http://dx.doi.org/10.1016/S0223-5234(02)01342-9

[8]. Sondhi, S. M.; Singhal, N.; Johar, M.; Reddy, B. S.; Lown, J. W. Curr. Med. Chem. 2002, 9, 1045-1074.
http://dx.doi.org/10.2174/0929867024606678
PMid:12733983

[9]. Demirayak, S.; Mohsen, U. A.; Karaburun, A. C. Eur. J. Med. Chem. 2002, 37, 225-260.
http://dx.doi.org/10.1016/S0223-5234(01)01313-7

[10]. Huang, S. T.; Hsei, I. J.; Chen, C. Bioorg. Med. Chem. 2006, 14, 6106-6119.
http://dx.doi.org/10.1016/j.bmc.2006.05.007

[11]. Boiani, M.; Gonzalez, M. Mini-Rev. Med. Chem. 2005, 5, 409-424.
http://dx.doi.org/10.2174/1389557053544047
PMid:15853629

[12]. Hori, A.; Imaeda, Y.; Kubo, K.; Kusaka, M. Cancer lett. 2002, 183, 53-62.
http://dx.doi.org/10.1016/S0304-3835(02)00110-6

[13]. Nawrocka, W; Sztuba, B.; Kowalska, M. W.; Liszkiewicz, H.; Wietrzyk, J.; Nasulewicz, A.; Pelczynska, M.; Opolski, A. Il Farmaco 2004, 59(2), 83-91.
http://dx.doi.org/10.1016/j.farmac.2003.12.001
PMid:14871499

[14]. Mosmann, T. J. Immunol. Methods 1983, 65(1-2), 55-63.

Supporting Agencies

Sana’a University, Sana’a, Yemen
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).