European Journal of Chemistry

Anticancer activity studies of some cyclic benzimidazole derivatives

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Ali El-Shekeil
Abeer Omer Obeid
Sama Al-Aghbari


New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.


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El-Shekeil, A.; Obeid, A. O.; Al-Aghbari, S. Anticancer Activity Studies of Some Cyclic Benzimidazole Derivatives. Eur. J. Chem. 2012, 3, 356-358.

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Sana’a University, Sana’a, Yemen
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