European Journal of Chemistry 2012, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621

Anticancer activity studies of some cyclic benzimidazole derivatives


Ali El-Shekeil (1,*) , Abeer Omer Obeid (2) , Sama Al-Aghbari (3)

(1) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(2) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(3) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(*) Corresponding Author

Received: 23 Apr 2012, Accepted: 17 Jun 2012, Published: 30 Sep 2012

Abstract


New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.

3_3_356_358_800


Keywords


PC3 cells; Hela cells; Cytotoxicity; Anti-cancer activity; Benzimidazole derivatives; 4-Amino-2-(3,4,5-trimethoxyphenyl)benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrile

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DOI: 10.5155/eurjchem.3.3.356-358.621

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Citations

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[1]. Mudumala Veeranarayana Reddy, Kang Rok Byeon, Su Hong Park, Dong Wook Kim
Polyethylene glycol methacrylate-grafted dicationic imidazolium-based ionic liquid: Heterogeneous catalyst for the synthesis of aryl-benzo[4,5]imidazo[1,2- a ]pyrimidine amines under solvent-free conditions
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[2]. Amol Maruti Jadhav, Yeong Il Kim, Kwon Taek Lim, Yeon Tae Jeong
Application of p -TSA in the one pot synthesis of N -methyl-3-nitro-aryl-benzo[4,5]imidazo[1,2- a ]pyrimidin-2-amine
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[3]. V. A. Risley, S. Henry, M. V. Kosyrikhina, M. R. Manzanares, I. Payan, C. D. Downer, C. C. Hellmann, S. Van Slambrouck, L. V. Frolova
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[4]. Shuai Fang, Xiaoyi Niu, Bingchuan Yang, Yanqiu Li, Xiaomeng Si, Lei Feng, Chen Ma
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[5]. Ali Gumaan El-Shekeil, Abeer Omer Abubakr, Sama Abdalla Al-Aghbari, Mogahid Yahya Nassar
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[6]. Dong Young Kim, Pham Duy Quang Dao, Chan Sik Cho
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[7]. Pham Duy Quang Dao, Ha Kyeong Lee, Ho-Sang Sohn, Nam Sik Yoon, Chan Sik Cho
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[8]. Tariq A. Shah, Waseem Raza, M. Muneer, Niyaz A. Mir, Musheer Ahmad
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How to cite


El-Shekeil, A.; Obeid, A.; Al-Aghbari, S. Eur. J. Chem. 2012, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, A.; Obeid, A.; Al-Aghbari, S. Anticancer activity studies of some cyclic benzimidazole derivatives. Eur. J. Chem. 2012, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, A., Obeid, A., & Al-Aghbari, S. (2012). Anticancer activity studies of some cyclic benzimidazole derivatives. European Journal of Chemistry, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, Ali, Abeer Omer Obeid, & Sama Al-Aghbari. "Anticancer activity studies of some cyclic benzimidazole derivatives." European Journal of Chemistry [Online], 3.3 (2012): 356-358. Web. 17 Sep. 2019
El-Shekeil, Ali, Obeid, Abeer, AND Al-Aghbari, Sama. "Anticancer activity studies of some cyclic benzimidazole derivatives" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.3.356-358.621

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