

Knoevenagel condensation of isatins with malononitrile/ethyl cyanoacetate in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) as a new nano-reactor
Negar Lashgari (1)




(1) Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran
(2) Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran
(3) School of Chemistry, College of Science, University of Tehran, 14155-6455, Tehran, Iran
(4) Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran
(*) Corresponding Author
Received: 02 Jul 2012 | Accepted: 12 Jul 2012 | Published: 30 Sep 2012 | Issue Date: September 2012
Abstract
The Knoevenagel condensation between isatins and active methylene compounds like malononitrile and ethyl cyanoacetate to prepare 2-oxoindolin-3-ylidene malononitrile/ cyanoacetates is described. The reactions occur in the presence of sulfonic acid functionalized silica SBA-15 (SBA-Pr-SO3H) in an aqueous medium giving excellent yields of the products in short reaction times. SBA-Pr-SO3H with a pore size of 6 nm is found to be an efficient and environmentally benign catalyst for this reaction.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.3.3.310-313.659
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Research Council of Alzahra University and University of Tehran, Iran
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[14]. Luyi Zhu, Peipei Yan, Lvye Zhang, Zhangtao Chen, Xiaofei Zeng, Guofu Zhong
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