European Journal of Chemistry

Knoevenagel condensation of isatins with malononitrile/ethyl cyanoacetate in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) as a new nano-reactor

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Published: Sep 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.3.310-313.659
Keywords:
Isatin, SBA-Pr-SO3H, Nano-reactor, Malononitrile, Knoevenagel condensation, 2-Oxoindolin-3-ylidene malononitrile
Section
Research Article
Issue
Vol. 3 No. 3 (2012): September 2012
Dates
Received 2012-07-02
Accepted 2012-07-12
Published 2012-09-30


Main Article Content

Negar Lashgari
Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran
Ghodsi Mohammadi Ziarani
Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran
Alireza Badiei
School of Chemistry, College of Science, University of Tehran, 14155-6455, Tehran, Iran
Parisa Gholamzadeh
Department of Chemistry, Alzahra University, Vanak Square, 199389-1176, Tehran, Iran

Abstract

The Knoevenagel condensation between isatins and active methylene compounds like malononitrile and ethyl cyanoacetate to prepare 2-oxoindolin-3-ylidene malononitrile/ cyanoacetates is described. The reactions occur in the presence of sulfonic acid functionalized silica SBA-15 (SBA-Pr-SO3H) in an aqueous medium giving excellent yields of the products in short reaction times. SBA-Pr-SO3H with a pore size of 6 nm is found to be an efficient and environmentally benign catalyst for this reaction.

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Lashgari, N.; Ziarani, G. M.; Badiei, A.; Gholamzadeh, P. Knoevenagel Condensation of Isatins With Malononitrile Ethyl Cyanoacetate in the Presence of Sulfonic Acid Functionalized Silica (SBA-Pr-SO3H) As a New Nano-Reactor. Eur. J. Chem. 2012, 3, 310-313.

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Supporting Agencies

Research Council of Alzahra University and University of Tehran, Iran
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