European Journal of Chemistry

Knoevenagel condensation of isatins with malononitrile/ethyl cyanoacetate in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) as a new nano-reactor

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Negar Lashgari
Ghodsi Mohammadi Ziarani
Alireza Badiei
Parisa Gholamzadeh


The Knoevenagel condensation between isatins and active methylene compounds like malononitrile and ethyl cyanoacetate to prepare 2-oxoindolin-3-ylidene malononitrile/ cyanoacetates is described. The reactions occur in the presence of sulfonic acid functionalized silica SBA-15 (SBA-Pr-SO3H) in an aqueous medium giving excellent yields of the products in short reaction times. SBA-Pr-SO3H with a pore size of 6 nm is found to be an efficient and environmentally benign catalyst for this reaction.


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Lashgari, N.; Ziarani, G. M.; Badiei, A.; Gholamzadeh, P. Knoevenagel Condensation of Isatins With Malononitrile Ethyl Cyanoacetate in the Presence of Sulfonic Acid Functionalized Silica (SBA-Pr-SO3H) As a New Nano-Reactor. Eur. J. Chem. 2012, 3, 310-313.

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Research Council of Alzahra University and University of Tehran, Iran
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