

Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography
Tadjuddin Naid (1)





(1) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(2) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(3) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(4) Chemistry Department, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia
(5) Chemistry Education Study Program, Faculty of Teacher Training and Education, Tadulako University, Palu, 94118, Indonesia
(*) Corresponding Author
Received: 14 Sep 2012 | Accepted: 02 Nov 2012 | Published: 31 Mar 2013 | Issue Date: March 2013
Abstract
The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.

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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.1.58-60.678
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References
[1]. Aznan, H. J.; Juli, S. Use of Anti-Inflammatory Non-Steroidal Rational at Tackling Rheumatic Pain. South Sumatera University Publishing, 2004.
[2]. Ferdiansyah, F. Behavior of Ketoprofen Diffusion through the Chitosan-CMC membrane. Bogor Agricultural Institute Publishing, 2009.
PMid:18651245
[3]. Epshtein, N. A. Pharm. Chem. J. 2005, 34(4), 212-228.
[4]. Qomariah, N. The Influence of an Tromethamine Organic amine base to the solubility of ketoprofen, Airlangga University Publishing, 2007.
[5]. Ermer, J. Method Validation in Pharmaceutical Analysis. Weinheim: Wiley-VCH Verlag GmbH & Co. KgaA, 2005.
http://dx.doi.org/10.1002/3527604685
[6]. Brown, P.; Deantonis, K. High Performance Liquid Chromatography, In. F. A., Settel (eds), Handbook or Instrumental Techniques for Analytical Chemistry, Prentice-Hall Inc., 1997.
[7]. Darnpanid, U. The effect of Phospholipid as Penetration Enhancer on Skin Permeation of Ketoprofen, Mahidol University Publishing, 2004.
[8]. Mallikarjuna, N. R.; Kondi, R. K.; Bagyalakshmi, J.; Ravi, T. K.; Ramakotaiah, M. Int. J. Res. Pharm. Sci. 2010, 1(2), 190-194.
[9]. Marcio, F.; Liberato, B. J.; Micheli, W.; Thiago, B.; Sergio, L. D. Acta Farm. 2006, 25 (1), 117-122.
[10]. World Health Organization. Validation of analytical Procedures Used in The examination of Pharmaceutical Materials, WHO Technical Report Series No. 823, 2007.
[11]. United States Pharmacopeia. The National Formulary 30th edition, The United States Pharmacopeia Convention, 1407, 2007.
[12]. Srinivasu, K.; Vankateswara, J. R.; Appala, N. R.; Mukkanti, K. E-J. Chem. 2011, 8(1), 453-456.
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DOI Link: https://doi.org/10.5155/eurjchem.4.1.58-60.678

















European Journal of Chemistry 2013, 4(1), 58-60 | doi: https://doi.org/10.5155/eurjchem.4.1.58-60.678 | Get rights and content
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