European Journal of Chemistry

Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography



Main Article Content

Tadjuddin Naid
Wahyu Rizandi Syukur
Amran Ilyas
Seniwati Dali
Baharuddin Hamzah

Abstract

The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.

4_1_58_60

icon graph This Abstract was viewed 1538 times | icon graph Article PDF downloaded 667 times

How to Cite
(1)
Naid, T.; Syukur, W. R.; Ilyas, A.; Dali, S.; Hamzah, B. Validation of Analysis Method for Determining Ketoprofen Concentration in Pharmaceutical Dosage Form Using High Performance Liquid Chromatography. Eur. J. Chem. 2013, 4, 58-60.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Aznan, H. J.; Juli, S. Use of Anti-Inflammatory Non-Steroidal Rational at Tackling Rheumatic Pain. South Sumatera University Publishing, 2004.

[2]. Ferdiansyah, F. Behavior of Ketoprofen Diffusion through the Chitosan-CMC membrane. Bogor Agricultural Institute Publishing, 2009.
PMid:18651245

[3]. Epshtein, N. A. Pharm. Chem. J. 2005, 34(4), 212-228.

[4]. Qomariah, N. The Influence of an Tromethamine Organic amine base to the solubility of ketoprofen, Airlangga University Publishing, 2007.

[5]. Ermer, J. Method Validation in Pharmaceutical Analysis. Weinheim: Wiley-VCH Verlag GmbH & Co. KgaA, 2005.
http://dx.doi.org/10.1002/3527604685

[6]. Brown, P.; Deantonis, K. High Performance Liquid Chromatography, In. F. A., Settel (eds), Handbook or Instrumental Techniques for Analytical Chemistry, Prentice-Hall Inc., 1997.

[7]. Darnpanid, U. The effect of Phospholipid as Penetration Enhancer on Skin Permeation of Ketoprofen, Mahidol University Publishing, 2004.

[8]. Mallikarjuna, N. R.; Kondi, R. K.; Bagyalakshmi, J.; Ravi, T. K.; Ramakotaiah, M. Int. J. Res. Pharm. Sci. 2010, 1(2), 190-194.

[9]. Marcio, F.; Liberato, B. J.; Micheli, W.; Thiago, B.; Sergio, L. D. Acta Farm. 2006, 25 (1), 117-122.

[10]. World Health Organization. Validation of analytical Procedures Used in The examination of Pharmaceutical Materials, WHO Technical Report Series No. 823, 2007.

[11]. United States Pharmacopeia. The National Formulary 30th edition, The United States Pharmacopeia Convention, 1407, 2007.

[12]. Srinivasu, K.; Vankateswara, J. R.; Appala, N. R.; Mukkanti, K. E-J. Chem. 2011, 8(1), 453-456.

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).