OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography
Tadjuddin Naid (1) , Wahyu Rizandi Syukur (2) , Amran Ilyas (3) , Seniwati Dali (4) , Baharuddin Hamzah (5,*)
(1) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(2) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(3) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(4) Chemistry Department, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia
(5) Chemistry Education Study Program, Faculty of Teacher Training and Education, Tadulako University, Palu, 94118, Indonesia
(*) Corresponding Author
Received: 14 Sep 2012 | Accepted: 02 Nov 2012 | Published: 31 Mar 2013 | Issue Date: March 2013
The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.
Links for Article
| | | | | | |
| | | | | | |
| | | |
Article MetricsThis Abstract was viewed 1069 times | PDF Article downloaded 355 times
. Aznan, H. J.; Juli, S. Use of Anti-Inflammatory Non-Steroidal Rational at Tackling Rheumatic Pain. South Sumatera University Publishing, 2004.
. Ferdiansyah, F. Behavior of Ketoprofen Diffusion through the Chitosan-CMC membrane. Bogor Agricultural Institute Publishing, 2009.
. Epshtein, N. A. Pharm. Chem. J. 2005, 34(4), 212-228.
. Qomariah, N. The Influence of an Tromethamine Organic amine base to the solubility of ketoprofen, Airlangga University Publishing, 2007.
. Ermer, J. Method Validation in Pharmaceutical Analysis. Weinheim: Wiley-VCH Verlag GmbH & Co. KgaA, 2005.
. Brown, P.; Deantonis, K. High Performance Liquid Chromatography, In. F. A., Settel (eds), Handbook or Instrumental Techniques for Analytical Chemistry, Prentice-Hall Inc., 1997.
. Darnpanid, U. The effect of Phospholipid as Penetration Enhancer on Skin Permeation of Ketoprofen, Mahidol University Publishing, 2004.
. Mallikarjuna, N. R.; Kondi, R. K.; Bagyalakshmi, J.; Ravi, T. K.; Ramakotaiah, M. Int. J. Res. Pharm. Sci. 2010, 1(2), 190-194.
. Marcio, F.; Liberato, B. J.; Micheli, W.; Thiago, B.; Sergio, L. D. Acta Farm. 2006, 25 (1), 117-122.
. World Health Organization. Validation of analytical Procedures Used in The examination of Pharmaceutical Materials, WHO Technical Report Series No. 823, 2007.
. United States Pharmacopeia. The National Formulary 30th edition, The United States Pharmacopeia Convention, 1407, 2007.
. Srinivasu, K.; Vankateswara, J. R.; Appala, N. R.; Mukkanti, K. E-J. Chem. 2011, 8(1), 453-456.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.4.1.58-60.678
| | | | | | | | |
| | | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2013, 4(1), 58-60 | doi: https://doi.org/10.5155/eurjchem.4.1.58-60.678 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2021 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.