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Synthesis of bis(indolyl)methanes using molten N-butylpyridinium bromide
Gaurav Gupta (1)
, Ganesh Chaudhari (2) , Preeti Tomar (3) , Yogesh Gaikwad (4) , Rameez Azad (5) , Girish Pandya (6) , Govinda Waghulde (7) , Kesharsingh Patil (8,*) (1) School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, India
(2) Department of Chemistry, Moolji Jaitha College, Jalgaon, 425001, India
(3) Department of Applied Chemistry, Jaywant Shikshan Prasarak Mandal’s Rajashi Shahu College of Engineering, Pune, 411027, India
(4) Anacon Laboratories, Nagpur, 440010, India
(5) Anacon Laboratories, Nagpur, 440010, India
(6) Anacon Laboratories, Nagpur, 440010, India
(7) Department of Chemistry, Dadasaheb Devidas Namdeo Bhole, College, Bhusawal, 425201, India
(8) School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, India
(*) Corresponding Author
Received: 16 Nov 2012 | Revised: 26 Nov 2012 | Accepted: 29 Nov 2012 | Published: 31 Dec 2012 | Issue Date: December 2012
Abstract
A simple and rapid protocol has been developed for the synthesis of bis(indolyl)methane compounds in excellent yields using molten N-butyl-pyridinium bromide as a solvent and a working catalyst for the reaction. Synthesis of bis(indolyl)methane compounds were accomplished at moderate experimental conditions of temperature and ambient pressure, also involving an electrophilic substitution reaction of indoles with several aromatic aldehydes. The derivatives were confirmed with mass and other usual spectroscopic techniques. A discussion on plausible mechanism for the reaction is also presented.
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DOI: 10.5155/eurjchem.3.4.475-479.709
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