European Journal of Chemistry 2013, 4(1), 44-48. doi:10.5155/eurjchem.4.1.44-48.717

Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide


Luciana Gavernet (1) , Maria Luisa Villalba (2) , Luis Bruno Blanch (3) , Ileana Daniela Lick (4,*)

(1) Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
(2) Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
(3) Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, La Plata, B1900BJW, Argentina
(4) Department of Chemistry, Faculty of Exact Sciences, National University of La Plata, CINDECA (CCT-La Plata-CONICET-UNLP), La Plata, B1900BJW, Argentina
(*) Corresponding Author

Received: 17 Dec 2012, Accepted: 05 Jan 2013, Published: 31 Mar 2013

Abstract


In this investigation, a kinetic study of the thermolysis of N-(benzyl)-N´-(tert-butoxycarbonyl) sulfamide to yield benzylsulfamide in an efficient manner was performed. The thermolysis reaction was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 10 oC/min. The activation energy value was obtained from the Kissinger-Akahira-Sunose isoconversional method and theoretical calculations (from Transition State Theory). The reaction model of the process was studied by means of the master-plot method. Results obtained from experiments of thermolysis performed under the melting point temperature of N-(benzyl)-N´-(tert-butoxycarbonyl) sulfamide fit with an Avrami-Erofeev model whereas data found for experiments at higher temperatures fit with first order model. Isothermal experiments were simulated at 115, 120 and 130 oC using the model-free method, employing only the activation energy value.

4_1_44_48

Keywords


Sulfamides; Kinetic study; Benzylsulfamide; Model-free method; Thermolysis reaction; Isoconversional method

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DOI: 10.5155/eurjchem.4.1.44-48.717

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[1]. H. R. Pouretedal, R. Ebadpour
Application of Non-Isothermal Thermogravimetric Method to Interpret the Decomposition Kinetics of $$\hbox {NaNO}_{3}, \hbox {KNO}_{3}$$ NaNO 3 , KNO 3 , and $$\hbox {KClO}_{4}$$ KClO 4
International Journal of Thermophysics  35(5), 942, 2014
DOI: 10.1007/s10765-014-1636-y
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How to cite


Gavernet, L.; Villalba, M.; Blanch, L.; Lick, I. Eur. J. Chem. 2013, 4(1), 44-48. doi:10.5155/eurjchem.4.1.44-48.717
Gavernet, L.; Villalba, M.; Blanch, L.; Lick, I. Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide. Eur. J. Chem. 2013, 4(1), 44-48. doi:10.5155/eurjchem.4.1.44-48.717
Gavernet, L., Villalba, M., Blanch, L., & Lick, I. (2013). Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide. European Journal of Chemistry, 4(1), 44-48. doi:10.5155/eurjchem.4.1.44-48.717
Gavernet, Luciana, Maria Luisa Villalba, Luis Bruno Blanch, & Ileana Daniela Lick. "Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide." European Journal of Chemistry [Online], 4.1 (2013): 44-48. Web. 16 Sep. 2019
Gavernet, Luciana, Villalba, Maria, Blanch, Luis, AND Lick, Ileana. "Kinetic study of benzyl sulfamide synthesis by thermolysis of N-(benzyl)-N´-(tert-butoxycarbolyl) sulfamide" European Journal of Chemistry [Online], Volume 4 Number 1 (31 March 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.1.44-48.717

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