European Journal of Chemistry 2013, 4(1), 74-84 | doi: https://doi.org/10.5155/eurjchem.4.1.74-84.739 | Get rights and content

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On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview


Juliana Ivanova (1,*) , Yordanka Gluhcheva (2) , Denitsa Tsanova (3) , Angelina Piskova (4) , Radostina Djaleva (5) , Steliana Mokresheva (6) , Dimitrina Kamenova (7) , Mariana Mitewa (8)

(1) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(2) Institute of Experimental Morphology, Pathology and Anthropology with Museum, BAS, 1113, Sofia, Bulgaria
(3) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(4) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(5) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(6) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(7) Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
(8) Faculty of Chemistry and Pharmacy, Sofia University, “St. Kl. Ohridski”, 1164 Sofia, Bulgaria
(*) Corresponding Author

Received: 31 Jan 2013 | Accepted: 16 Feb 2013 | Published: 31 Mar 2013 | Issue Date: March 2013

Abstract


Cadmium (Cd) has been classified as a human carcinogen. The World Health Organization (WHO) reported that the concentration of Cd in the environment has rapidly increased in the last few years. In many epidemiological studies, the correlation between environmental exposure of humans to Cd and diseases such as stroke, ischemia, renal and hepatic dysfunction, anemia, osteoporosis and diabetes has been discussed. For the treatment of heavy metal intoxications a therapy with chelating agents has been applied. A chelating agent is a compound that binds the toxic metal ion thus promoting its excretion by the living organisms. Recently, it has been found that Cd-induced toxicity is a result of formation of reactive oxygen species (ROS). These results increased the interest towards the antioxidants as possible agents for the treatment of Cd-induced organ toxicity. Herein, we present summary and discussion of the literature data for the influence of chelating agents and antioxidants on Cd-induced pathological conditions in Cd-intoxicated animals.

4_1_74_84

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Editor-in-Chief
European Journal of Chemistry

Keywords


Vitamins; Cadmium; Toxicology; Ionophores; Antioxidants; Medicinal chemistry

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DOI: 10.5155/eurjchem.4.1.74-84.739

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How to cite


Ivanova, J.; Gluhcheva, Y.; Tsanova, D.; Piskova, A.; Djaleva, R.; Mokresheva, S.; Kamenova, D.; Mitewa, M. Eur. J. Chem. 2013, 4(1), 74-84. doi:10.5155/eurjchem.4.1.74-84.739
Ivanova, J.; Gluhcheva, Y.; Tsanova, D.; Piskova, A.; Djaleva, R.; Mokresheva, S.; Kamenova, D.; Mitewa, M. On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview. Eur. J. Chem. 2013, 4(1), 74-84. doi:10.5155/eurjchem.4.1.74-84.739
Ivanova, J., Gluhcheva, Y., Tsanova, D., Piskova, A., Djaleva, R., Mokresheva, S., Kamenova, D., & Mitewa, M. (2013). On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview. European Journal of Chemistry, 4(1), 74-84. doi:10.5155/eurjchem.4.1.74-84.739
Ivanova, Juliana, Yordanka Gluhcheva, Denitsa Tsanova, Angelina Piskova, Radostina Djaleva, Steliana Mokresheva, Dimitrina Kamenova, & Mariana Mitewa. "On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview." European Journal of Chemistry [Online], 4.1 (2013): 74-84. Web. 3 Jun. 2023
Ivanova, Juliana, Gluhcheva, Yordanka, Tsanova, Denitsa, Piskova, Angelina, Djaleva, Radostina, Mokresheva, Steliana, Kamenova, Dimitrina, AND Mitewa, Mariana. "On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview" European Journal of Chemistry [Online], Volume 4 Number 1 (31 March 2013)

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