European Journal of Chemistry 2013, 4(4), 459-461 | doi: https://doi.org/10.5155/eurjchem.4.4.459-461.821 | Get rights and content

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One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst


Mohsen Abdel-Motaal Gomaa (1,*) , Abdel-Wahed Rashad Sayed (2) , Ragab Ali Masoud (3)

(1) Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt
(2) Chemistry Department, Faculty of Science, Beni Suef University, 62511 Beni Suef, Egypt
(3) College of Agriculture and Food Sciences, King Faisal University, Al-Hufuf 31982, Saudi Arabia
(*) Corresponding Author

Received: 03 May 2013 | Revised: 07 Jun 2013 | Accepted: 09 Jun 2013 | Published: 31 Dec 2013 | Issue Date: December 2013

Abstract


Tetrahydroquinazolinone derivatives were synthesized in moderate to high yields via one‐pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of molecular iodine as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work‐up procedure.

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Keywords


Urea; Dimedone; Biginelli reaction; Molecular iodine; Tetrahydroquinazolinone; Tetrahydroquinazolinthione

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DOI: 10.5155/eurjchem.4.4.459-461.821

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Funding information


King Faisal University, Al-Hufuf 31982, Saudi Arabia

Citations

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[1]. Parviz Movaheditabar, Mohammad Javaherian, Valiollah Nobakht
Synthesis and catalytic application of a curcumin‐based bio‐MOF in one‐pot preparation of tetrahydroquinazolinone derivatives via Biginelli reaction
Applied Organometallic Chemistry  36(4), , 2022
DOI: 10.1002/aoc.6602
/


[2]. Nisheeth C. Desai, Surbhi B. Joshi, Krunalsinh A. Jadeja
A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents
Journal of Heterocyclic Chemistry  57(2), 791, 2020
DOI: 10.1002/jhet.3821
/


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How to cite


Gomaa, M.; Sayed, A.; Masoud, R. Eur. J. Chem. 2013, 4(4), 459-461. doi:10.5155/eurjchem.4.4.459-461.821
Gomaa, M.; Sayed, A.; Masoud, R. One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst. Eur. J. Chem. 2013, 4(4), 459-461. doi:10.5155/eurjchem.4.4.459-461.821
Gomaa, M., Sayed, A., & Masoud, R. (2013). One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst. European Journal of Chemistry, 4(4), 459-461. doi:10.5155/eurjchem.4.4.459-461.821
Gomaa, Mohsen, Abdel-Wahed Rashad Sayed, & Ragab Ali Masoud. "One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst." European Journal of Chemistry [Online], 4.4 (2013): 459-461. Web. 26 Nov. 2022
Gomaa, Mohsen, Sayed, Abdel-Wahed, AND Masoud, Ragab. "One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst" European Journal of Chemistry [Online], Volume 4 Number 4 (31 December 2013)

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DOI Link: https://doi.org/10.5155/eurjchem.4.4.459-461.821


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