

One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst
Mohsen Abdel-Motaal Gomaa (1,*)



(1) Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt
(2) Chemistry Department, Faculty of Science, Beni Suef University, 62511 Beni Suef, Egypt
(3) College of Agriculture and Food Sciences, King Faisal University, Al-Hufuf 31982, Saudi Arabia
(*) Corresponding Author
Received: 03 May 2013 | Revised: 07 Jun 2013 | Accepted: 09 Jun 2013 | Published: 31 Dec 2013 | Issue Date: December 2013
Abstract
Tetrahydroquinazolinone derivatives were synthesized in moderate to high yields via one‐pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of molecular iodine as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work‐up procedure.

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European Journal of Chemistry
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DOI: 10.5155/eurjchem.4.4.459-461.821
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King Faisal University, Al-Hufuf 31982, Saudi Arabia
Citations
[1]. Parviz Movaheditabar, Mohammad Javaherian, Valiollah Nobakht
Synthesis and catalytic application of a curcumin‐based bio‐MOF in one‐pot preparation of tetrahydroquinazolinone derivatives via Biginelli reaction
Applied Organometallic Chemistry 36(4), , 2022
DOI: 10.1002/aoc.6602

[2]. Nisheeth C. Desai, Surbhi B. Joshi, Krunalsinh A. Jadeja
A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents
Journal of Heterocyclic Chemistry 57(2), 791, 2020
DOI: 10.1002/jhet.3821

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DOI Link: https://doi.org/10.5155/eurjchem.4.4.459-461.821

















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