Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
SHORT COMMUNICATION
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity of novel dihydropyridine derivatives
Ayaz Anwar (1)
, Abdul Hameed (2,*) , Shahida Perveen (3) , Maliha Uroos (4) , Muhammad Iqbal Choudhary (5) , Fatima Zahra Basha (6) (1) Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(2) Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(3) Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(4) Institute of Agricultural Sciences, University of the Punjab, Quaid-e-Azam Campus, Lahore, 54590 Pakistan
(5) Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah-21412, Saudi Arabia
(6) Husein Ebrahim Jamal Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(*) Corresponding Author
Received: 04 Sep 2013 | Revised: 25 Oct 2013 | Accepted: 26 Oct 2013 | Published: 31 Mar 2014 | Issue Date: March 2014
Abstract
Thirteen dihydropyridine analogues 1-13 were synthesized and evaluated for their DPPH radical scavenging activity. A good to moderate antioxidant activity ranging from 127.4 to 284.5 μM was observed and structure-activity relationship was established. The 3'-fluoro derivative 8 (IC50 = 127.4±3.5 μM) was found to exhibit highest activity among the dihydro pyridine derivatives 1-13, while the other derivatives 11 (IC50 = 132.5±3.32 μM), 6 (IC50 = 142.2±0.60 μM), 10 (IC50 = 144.7±2.46 μM), 12 (IC50 = 153.7±0.50 μM), 5 (IC50 = 161.4±2.81 μM) and 5 (IC50 = 164.4±2.50 μM) possess moderate activity, depends upon the C-4 and C-6 substituted groups. The compounds 7, 13, 4, 3 and 2 have lowest IC50 values, ranging between 172.8 and 284.5 μM. Dihydropyridine analogues were characterized by spectroscopic techniques.
Announcements
One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.5.1.189-191.916
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 1705 times |
PDF Article downloaded 686 times
Funding information
Higher Education Commission (HEC), Pakistan and Husein Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Citations
[1]. Ayaz Anwar, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad R. Shah, Naveed A. Khan
Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents
Medicinal Chemistry 16(7), 841, 2020
DOI: 10.2174/1573406415666190722113412
References
[1]. Cui, H.; Kong, Y.; Zhang, H. J. Signal Transduct. 2012, 2012, 646-354.
[2]. Beckman, K. B.; Ames, B. N. Physiol. Rev. 1998, 78, 547-581.
[3]. Martinez-Martinez, F.; Razo-Hernandez, R.; Peraza-Campos, A.; Villanueva-Garcia, M.; Sumaya-Martinez, M.; Cano, D.; Gomez-Sandoval, Z. Molecules 2012, 17, 14882-14898.
http://dx.doi.org/10.3390/molecules171214882
[4]. Meyer, A. S.; Heinonen, M.; Frankel, E. N. Food Chem. 1998, 61, 71-75.
http://dx.doi.org/10.1016/S0308-8146(97)00100-3
[5]. Hunt, E. J.; Lester, C. E.; Lester, E. A.; Tackett, R. L. Life Sci. 2001, 69, 181-190.
http://dx.doi.org/10.1016/S0024-3205(01)01102-X
[6]. Schmidley, J. W. Stroke 1990, 21, 1086-1090.
http://dx.doi.org/10.1161/01.STR.21.7.1086
[7]. Rice-Evans, C. A.; Miller, N. J.; Paganga, G. Free Radical Biol. Med. 1996, 20, 933-956.
http://dx.doi.org/10.1016/0891-5849(95)02227-9
[8]. Villano, D.; Fernandez-Pachon, M. S.; Moya, M. L.; Troncoso, A. M.; Garcia-Parrilla, M. C. Talanta 2007, 71, 230-235.
http://dx.doi.org/10.1016/j.talanta.2006.03.050
[9]. Williams, R. J.; Spencer, J. P. E.; Rice-Evans, C. Free Radical Biol. Med. 2004, 36, 838-849.
http://dx.doi.org/10.1016/j.freeradbiomed.2004.01.001
[10]. Ajitha, M. J.; Mohanlal, S.; Suresh, C. H.; Jayalekshmy, A. J. Agric. Food Chem. 2012, 60, 3693-3699.
http://dx.doi.org/10.1021/jf204826e
[11]. Moure, A.; Cruz, J. M.; Franco, D.; Domıinguez, J. M.; Sineiro, J.; Dominguez, H.; Jose Nunez, M. A.; Parajo, J. C. Food Chem. 2001, 72, 145-171.
http://dx.doi.org/10.1016/S0308-8146(00)00223-5
[12]. Holiman, P. C. H.; Hertog, M. G. L.; Katan, M. B. Food Chem. 1996, 57, 43-46.
http://dx.doi.org/10.1016/0308-8146(96)00065-9
[13]. Hyoudou, K.; Nishikawa, M.; Kobayashi, Y.; Umeyama, Y.; Yamashita, F.; Hashida, M. Free Radical Biol. Med. 2006, 41, 1449-1458.
http://dx.doi.org/10.1016/j.freeradbiomed.2006.08.004
[14]. Chaubey, A.; Pandeya, S. N. Asian J. Pharm. Clin. Res. 2011, 4, 5-8.
[15]. Cominacini, L.; Fratta Pasini, A.; Garbin, U.; Pastorino, A. M.; Davoli, A.; Nava, C.; Campagnola, M.; Rossato, P.; Lo Cascio, V. Biochem. Biophys. Res. Commun. 2003, 302, 679-684.
http://dx.doi.org/10.1016/S0006-291X(03)00158-X
[16]. Augustyniak, A.; Bartosz, G.; Cipak, A.; Duburs, G.; Horakova, L.; Luczaj, W.; Majekova, M.; Odysseos, A. D.; Rackova, L.; Skrzydlewska, E.; Stefek, M.; Strosova, M.; Tirzitis, G.; Venskutonis, P. R.; Viskupicova, J.; Vraka, P. S.; Zarkovic, N. Free Radical Res. 2010, 44, 1216-1262.
http://dx.doi.org/10.3109/10715762.2010.508495
[17]. Hameed, A.; Anwar, A.; Yousaf, S.; Khan, K. M.; Basha, F. Z. Eur. J. Chem. 2012, 3, 179-185.
http://dx.doi.org/10.5155/eurjchem.3.2.179-185.562
[18]. Thadhani, V. M.; Choudhary, M. I.; Ali, S.; Omar, I.; Siddique, H.; Karunaratne, V. Nat. Prod. Res. 2011, 25, 1827-1837.
http://dx.doi.org/10.1080/14786419.2010.529546
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.5.1.189-191.916
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2014, 5(1), 189-191 | doi: https://doi.org/10.5155/eurjchem.5.1.189-191.916 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.