European Journal of Chemistry 2014, 5(1), 186-188. doi:10.5155/eurjchem.5.1.186-188.938

IL-17 level in patients with acute myocardial infarction and its effect on lipid profile

Ammal Esmaeel Ibrahim (1,*) , Hiba Ali Hasan (2) , Alaa Hussein Jawad (3)

(1) Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, 10072, Iraq
(2) Department of Clinical Laboratory Science, Collage of Pharmacy, Al-Mustansiriya University, Baghdad, 10052, Iraq
(3) Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, 10072, Iraq
(*) Corresponding Author

Received: 27 Sep 2013, Accepted: 26 Oct 2013, Published: 30 Mar 2014


Myocardial infarction (MI) is considered as the major cause of death and disability worldwide, and despite considerable advances in diagnosis and treatment, continues to be a major public health problem. Interleukin-17 (IL-17) is leukocyte-derived cytokine with effects especially on epithelial cells in various tissues. This study designed to investigate the level of IL-17 and its effect on lipid profile in patients with Acute Myocardial Infarction. The study included 50 patients with acute myocardial infarction forty healthy subjects as control group. The levels of IL-17 were significantly elevated in all patients groups (p < 0.001), total cholesterol, LDL, VLDL were significantly elevated (p < 0.001) in all patients as well.  There was positive correlation between IL-17 with HDL, while there was negative correlation with total cholesterol and LDL. The results show significant increase in levels of IL-17, in acute myocardial infarction patients. IL-17 positively correlated with HDL and negatively correlated with total cholesterol and LDL, which lead to consider it as cardio protective factor.


IL-17; Triglycerides; Total cholesterol; Low density lipoprotein; High density lipoprotein; Acute myocardial infarction

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DOI: 10.5155/eurjchem.5.1.186-188.938

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[1]. Liu, S.; Song, X.; Chrunyk, B. A.; Shanker, S.; Hoth, L. R.; Marr, E. S.; Griffor, M. C. Nature Commun. 2013, 4, 1888-1888.

[2]. Zhang, B.; Liu, C.; Qian, W.; Han, Y.; Li, X.; Deng, J. J. Immunol. 2013, 190(5), 2320-2326.

[3]. Janis, K.; Thomas, J.; Richard, A.; Barbara, A. Kuby Immunology. San Francisco, W. H. Freeman, 2007, pp. 396.

[4]. Chiricozzi, A.; Guttman-Yassky, E.; Suarez-Farinas, M.; Nograles, KE.; Tian, S.; Cardinale, I.; Chimenti, S.; Krueger, J. G. J. Invest. Dermatol. 2011, 131(3), 677-687.

[5]. Huang, C. S.; Timothy, R.; Arditi, M. Innate Immun. 2010, 2, 325-333.

[6]. Hansson, G. K.; Libby, P.; Schonbeck, U.; Yan, Z. Q. Circ. Res. 2002, 9(1), 281-291.

[7]. Hansson, G. K. N. Engl. J. Med. 2005, 352(16), 1685-1695.

[8]. O'Connor, W.; Kamanaka, M.; Booth, C. J.; Town, T.; Nakae, S.; Iwakura, Y.; Kolls, J. K.; Flavell, R. A. Nat. Immunol. 2009, 10, 603-609.

[9]. Butcher, M.; Galkina, E. Thromb. Haemost. 2011, 106, 787-795.

[10]. Smith, E.; Konkal-Matt, R.; Prasad, M. B.; AncaDobrian, J. K.; Kolls, K. L.; Elena, G. Circulation 2010, 121(15), 1746-1755.

[11]. Sergejeva, S.; Ivanov, S.; Lotvall, J.; Linden A. J. Respir. Cell. Mol. Biol. 2005, 33, 248-253.

[12]. Rao, D. A.; Eid, R. E.; Qin, L.; Yi, T.; Kirkiles-Smith, N. C.; Tellides, G.; Pober, J. S. J. Exp. Med. 2008, 205, 3145-3158.

[13]. Mohsen, I. M. Obes. Rev. 2010, 11, 11-18.

[14]. Erbel, C.; Chen, L.; Bea, F.; Wangler, S.; Celik, S.; Lasitschka, F.; Wang, Y.; Bockler, D.; Katus, H. A.; Dengler, T. J. J. Immunol. 2009, 183, 8167-8175.

[15]. Taleb, S.; Tedgui, A.; Mallat, Z. Curr. Opin. Pharmacol. 2010, 10, 197-202.

[16]. Gao, Q.; Jiang, Y.; Ma, T.; Zhu, F.; Gao, F.; Zhang, P.; Guo, C.; Wang, Q.; Wang, X.; Ma, C.; Zhang, Y.; Chen, W.; Zhang, L. J. Immunol. 2010, 185, 5820-5827.

[17]. Barry, S. P.; Ounzain, S.; Cormick, J. A.; Scarabelli, T. M.; Chen-Scarabelli, C.; Saravolatz, L. I. I.; Faggian, G.; Mazzucco, A.; Suzuki, H.; Thiemermann, C.; Knight, R. A.; Latchman, D. S.; Stephanou, A. Int. J. Cardiol. 2013, 163, 326-334.

[18]. Troitskaya, M.; Baysa, A.; Vaage, J.; Sand, K. L.; Maghazachi, A. A.; Valen, G. Toxins. 2012, 4, 1427-1439.

[19]. Zuniga, L. A.; Shen, W. J.; Joyce-Shaikh, B.; Pyatnova, E. A.; Richards, A. G.; Thom, C.; Andrade, S. M.; Cua, D. J.; Fredric B. Kraemer, F. B.; Butcher, E. C. J. Immunol. 2010, 185(11), 6947-6959.

[20]. Nuzhatun, N.; Qazi, M. A. Indian J. Dermatol. Venereol. Leprol. 2010, 76, 662-665.

[21]. Gastro, A. Am. J. Resp. Crit. Care 2010, 182(5), 661-668.

[22]. Canizales-Quinteros, S.; Aguilar-Salinas, C. A.; Reyes-Rodriguez, E.; Riba, L.; Rodriguez-Torres, M.; Ramirez-Jimenez, S.; Huertas-Vazquez, A.; Fragoso-Ontiveros, V.; Zentella-Dehesa, A.; Ventura-Gallegos, J. L.; Vega-Hernandez, G.; Lopez-Estrada, A. Auron-Gomez, M.; Gomez-Perez, F.; Rull, J.; Cox, N. J.; Bell, G. I.; Maria Teresa Tusie-Luna, M. T. Circ. Res. 2003, 92, 569-576.

[23]. Al-Aubaidy, H. A.; Sahib, H. A.; Mohammad, B. I.; Hadi, N. R.; Abas, S. M. J. Pharm. Tech. Drug Res. 2013, 2, 11. DOI: 10. 7243/2050-120X-2-11.

[24]. Smith, E.; Prasad, K. M.; Butcher, M.; Dobrian, A.; Kolls, J. K.; Ley, K.; Galkina, E. Circulation 2010, 121, 1746-1755.

[25]. Brull, F.; Mensink, R. P.; Steinbusch, M. F.; Husche, C.; Lutjohann, D.; Wesseling, G.; Plat, J. PLOS One. 2012, 7(10), e46895.

How to cite

Ibrahim, A.; Hasan, H.; Jawad, A. Eur. J. Chem. 2014, 5(1), 186-188. doi:10.5155/eurjchem.5.1.186-188.938
Ibrahim, A.; Hasan, H.; Jawad, A. IL-17 level in patients with acute myocardial infarction and its effect on lipid profile. Eur. J. Chem. 2014, 5(1), 186-188. doi:10.5155/eurjchem.5.1.186-188.938
Ibrahim, A., Hasan, H., & Jawad, A. (2014). IL-17 level in patients with acute myocardial infarction and its effect on lipid profile. European Journal of Chemistry, 5(1), 186-188. doi:10.5155/eurjchem.5.1.186-188.938
Ibrahim, Ammal, Hiba Ali Hasan, & Alaa Hussein Jawad. "IL-17 level in patients with acute myocardial infarction and its effect on lipid profile." European Journal of Chemistry [Online], 5.1 (2014): 186-188. Web. 16 Sep. 2019
Ibrahim, Ammal, Hasan, Hiba, AND Jawad, Alaa. "IL-17 level in patients with acute myocardial infarction and its effect on lipid profile" European Journal of Chemistry [Online], Volume 5 Number 1 (30 March 2014)

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