European Journal of Chemistry

New synthetic benzisoxazole derivatives as antimicrobial, antioxidant and anti-inflammatory agents

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Published: Dec 31, 2013
DOI: https://doi.org/10.5155/eurjchem.4.4.402-407.864
Keywords:
Piperidine, Antioxidant, Spirolactone, Antimicrobial, Benzisoxazole, Anti-inflammatory
Section
Research Article
Issue
Vol. 4 No. 4 (2013): December 2013
Dates
Received 2013-06-28
Accepted 2013-07-15
Published 2013-12-31


Main Article Content

Chalya Mallappaji Shivaprasad
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Swamy Jagadish
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Toreshettahally Ramesh Swaroop
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Chakrabhavi Dhananjaya Mohan
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Rangaswamy Roopashree
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Kothanahally Shivaramu Sharath Kumar
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
Kanchugarakoppal Subbegowda Rangappa
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India

Abstract

A series of piperidine conjugated benzisoxazole derivatives were synthesized and evaluated for their antibacterial, anti-oxidant and anti-inflammatory activities. The results showed that most of the tested compounds exhibit good to moderate antimicrobial activity against some strains of Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive bacteria (Bacillus subtilis). Further, the molecules were evaluated for anti-oxidant assays such as DPPH scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays. Most of the compounds showed potent antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays, where compounds revealed good activity.

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(1)
Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Kumar, K. S. S.; Rangappa, K. S. New Synthetic Benzisoxazole Derivatives As Antimicrobial, Antioxidant and Anti-Inflammatory Agents. Eur. J. Chem. 2013, 4, 402-407.

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