European Journal of Chemistry

Synthesis of new benzisoxazole derivatives and their antimicrobial, antioxidant and anti-inflammatory activities

Article Sidebar

PDF
Published: Mar 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.1.91-95.866
Keywords:
Piperidine, Antioxidant, Spirolactone, Benzisoxazole, Antimicrobial, Anti-inflammatory
Section
Research Article
Issue
Vol. 5 No. 1 (2014): March 2014
Dates
Received 2013-07-05
Accepted 2013-09-22
Published 2014-03-31


Main Article Content

Chalya Mallappaji Shivaprasad
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Swamy Jagadish
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Toreshettahally Ramesh Swaroop
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Chakrabhavi Dhananjaya Mohan
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Rangaswamy Roopashree
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Kothanahally Shivaramu Sharath Kumar
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
Kanchugarakoppal Subbegowda Rangappa
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India

Abstract

A series of benzisoxazole derivatives were synthesized and evaluated for their antibacterial, antioxidant and anti-inflammatory activities. The results indicated that most of the compounds exhibit moderate antimicrobial activity against Gram negative (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive (Bacillus subtilis) bacterial culture. The molecules were evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays and most of them showed good antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays.


icon graph This Abstract was viewed 1852 times | icon graph Article PDF downloaded 1057 times

How to Cite
(1)
Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Kumar, K. S. S.; Rangappa, K. S. Synthesis of New Benzisoxazole Derivatives and Their Antimicrobial, Antioxidant and Anti-Inflammatory Activities. Eur. J. Chem. 2014, 5, 91-95.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Priya, B. S.; Basappa,; Swamy, S. N.; Rangappa, K. S. Bioorg. Med. Chem. 2005, 13, 2623-2628.
http://dx.doi.org/10.1016/j.bmc.2005.01.026

[2]. Stiff, D. D.; Zemaitis, M. A. Drug Metab. Dispos. 1990, 18, 888-894.

[3]. Uno, H.; Kurokawa, M.; Masuda, Y.; Nishimura, H. J. Med. Chem. 1979, 22, 180-188.
http://dx.doi.org/10.1021/jm00188a011

[4]. Gopalsamy, A.; Shi, M.; Golas, J.; Vogan, E.; Jacob, J.; Johnson, M.; Lee, F.; Nilakantan, R.; Petersen, R.; Svenson, K.; Chopra, R.; Tam, M. S.; Wen, Y.; Ellingboe, J.; Arndt, K.; Boschelli, F. J. Med. Chem. 2008, 51, 373-379.
http://dx.doi.org/10.1021/jm701385c

[5]. Jain, M.; Kwon, C. H. J. Med. Chem. 2003, 46, 5428-5434.
http://dx.doi.org/10.1021/jm020581y

[6]. Davis, L.; Effland, R. C.; Klein, J. T.; Dunn, R. W.; Geyer, H. M.; Petko, W. M. Drug Design Disc. 1992, 8, 225-240.

[7]. Strupczewski, J. T.; Allen, R. C.; Gardner, B. A.; Schmid, B. L.; Stache, U.; Glamkowski, E. J.; Jones, M. C.; Ellis, D. B.; Huger, F. P.; Dunn, R. W. J. Med. Chem. 1985, 28, 761-767.
http://dx.doi.org/10.1021/jm00383a012

[8]. Janssen, P. A. J.; Niemegeers, C. J. E.; Awouters, F.; Schellekens, K. H. L.; Megens, A. A. H. P.; Meert, T. F. J. Pharmacol. Exp. Ther. 1988, 244, 685-691.

[9]. Nuhrich, A.; Varache-Lembege, M.; Renard, P.; Devaux, G. Eur. J. Med. Chem. 1994, 29, 75-82.
http://dx.doi.org/10.1016/0223-5234(94)90129-5

[10]. Hasegawa, H. Cur. Med. Res. Opin. 2004, 20, 577-586.
http://dx.doi.org/10.1185/030079904125003313

[11]. Shantharam, C. S.; Suyoga Vardhan, D. M.; Suhas, R.; Sridhara, M. B.; Channe Gowda, D. Eur. J. Med. Chem. 2013, 60, 325-332.
http://dx.doi.org/10.1016/j.ejmech.2012.12.029

[12]. Villalobos, A.; Blake, J. F.; Biggers, C. K.; Butler, T. W.; Chapin, D. S.; Chen, Y. L.; Ives, J. L.; Jones, S. B.; Liston, D. R.; Nagel, A. A.; Nason, D. M.; Nielsen, J. A.; Shalaby, I. A.; White, W. F. J. Med. Chem. 1994, 37, 2721-2730.
http://dx.doi.org/10.1021/jm00043a012

[13]. Rangappa, K. S.; Basappa. J. Phys. Chem. 2005, 18, 773-779.

[14]. Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Sharath Kumar, K. S.; Rangappa, K. S. Eur. J. Chem. 2013, 4, 402-407.
http://dx.doi.org/10.5155/eurjchem.4.4.402-407.864

[15]. Chuanga, Y. M. D.; Wanga, Y. S.; Kuob, Y. Y.; Tsaia, H. P.; Shyura, W. L. F. J. Ethnopharmacol. 2004, 95, 409-419.
http://dx.doi.org/10.1016/j.jep.2004.08.010

[16]. Halliwell, B.; Gutteridge, J. M. C.; Arnoma, O. L. Anal. Biochem. 1987, 165, 215-219.
http://dx.doi.org/10.1016/0003-2697(87)90222-3

[17]. Nishimiki, M.; Appaji, N.; Yagi, K. Biochem. Bioph. Res. Co. 1972, 46, 849-854.
http://dx.doi.org/10.1016/S0006-291X(72)80218-3

[18]. Shinde, U. A.; Kulkarni, K. R.; Phadke, A. S.; Nair, A. M.; Mungantiwar, D. V. J.; Saraf, M. N. Indian J. Exp. Biol. 1999, 371, 258-261.

[19]. Boman, H. G.; Kaletta, U Biochim. Biophys. Acta 1957, 24, 619-623.
http://dx.doi.org/10.1016/0006-3002(57)90256-1

[20]. Gaint, S.; Fitton, A. Drugs 1994, 48, 253-273.
http://dx.doi.org/10.2165/00003495-199448020-00009

Supporting Agencies

Board of Research in Nuclear Sciences (BRNS), University Grants Commission (UGC), Indo-French Centre for the Promotion of Advance Research (IFCPAR), Council of Scientific and Industrial Research (CSIR) for Junior and Senior Research Fellowship
Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).