European Journal of Chemistry

Synthesis of new benzisoxazole derivatives and their antimicrobial, antioxidant and anti-inflammatory activities



Main Article Content

Chalya Mallappaji Shivaprasad
Swamy Jagadish
Toreshettahally Ramesh Swaroop
Chakrabhavi Dhananjaya Mohan
Rangaswamy Roopashree
Kothanahally Shivaramu Sharath Kumar
Kanchugarakoppal Subbegowda Rangappa

Abstract

A series of benzisoxazole derivatives were synthesized and evaluated for their antibacterial, antioxidant and anti-inflammatory activities. The results indicated that most of the compounds exhibit moderate antimicrobial activity against Gram negative (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive (Bacillus subtilis) bacterial culture. The molecules were evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays and most of them showed good antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays.


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Shivaprasad, C. M.; Jagadish, S.; Swaroop, T. R.; Mohan, C. D.; Roopashree, R.; Kumar, K. S. S.; Rangappa, K. S. Synthesis of New Benzisoxazole Derivatives and Their Antimicrobial, Antioxidant and Anti-Inflammatory Activities. Eur. J. Chem. 2014, 5, 91-95.

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Supporting Agencies

Board of Research in Nuclear Sciences (BRNS), University Grants Commission (UGC), Indo-French Centre for the Promotion of Advance Research (IFCPAR), Council of Scientific and Industrial Research (CSIR) for Junior and Senior Research Fellowship
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