Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
New synthetic benzisoxazole derivatives as antimicrobial, antioxidant and anti-inflammatory agents
Chalya Mallappaji Shivaprasad (1)
, Swamy Jagadish (2) , Toreshettahally Ramesh Swaroop (3) , Chakrabhavi Dhananjaya Mohan (4) , Rangaswamy Roopashree (5) , Kothanahally Shivaramu Sharath Kumar (6) , Kanchugarakoppal Subbegowda Rangappa (7,*) (1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(5) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(6) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(7) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
(*) Corresponding Author
Received: 28 Jun 2013 | Revised: 19 Jul 2013 | Accepted: 22 Jul 2013 | Published: 31 Dec 2013 | Issue Date: December 2013
Abstract
A series of piperidine conjugated benzisoxazole derivatives were synthesized and evaluated for their antibacterial, anti-oxidant and anti-inflammatory activities. The results showed that most of the tested compounds exhibit good to moderate antimicrobial activity against some strains of Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Shigella flexineri) and Gram positive bacteria (Bacillus subtilis). Further, the molecules were evaluated for anti-oxidant assays such as DPPH scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays. Most of the compounds showed potent antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays, where compounds revealed good activity.
Announcements
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).
2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).
3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.4.4.402-407.864
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 1513 times |
PDF Article downloaded 704 times
Funding information
Board of Research in Nuclear Sciences (BRNS), University Grants Commission (UGC) and Indo-French Centre for the Promotion of Advance Research (IFCPAR)
Citations
[1]. Ajayrajsinh R. Zala, Premlata Kumari
Versatile Therapeutic Values of N‐Containing Heterocycles Benzimidazole, Piperazine and Piperidine Hybrids
ChemistrySelect 8(37), , 2023
DOI: 10.1002/slct.202301304
[2]. Chalya Mallappaji Shivaprasad, Swamy Jagadish, Toreshettahally Ramesh Swaroop, Chakrabhavi Dhananjaya Mohan, Rangaswamy Roopashree, Kothanahally Shivaramu Sharath Kumar, Kanchugarakoppal Subbegowda Rangappa
Synthesis of new benzisoxazole derivatives and their antimicrobial, antioxidant and anti-inflammatory activities
European Journal of Chemistry 5(1), 91, 2014
DOI: 10.5155/eurjchem.5.1.91-95.866
[3]. Rajendra K. Wanare, Rajendra R. Tayade, Abhilash A. Sukhadeve, Prafulla P. Choudhari, R. G. Mahakale, Nihal Mishra
Synthesis and Biofunctional Evaluation of Novel Isoxazole, C-Nucleoside, and Thioxopyrimidine Derivatives
Oriental Journal Of Chemistry 39(5), 1313, 2023
DOI: 10.13005/ojc/390526
References
[1] Priya, B. S.; Basappa; Swamy, S. N.; Rangappa, K. S. Bioorg. Med. Chem. 2005, 13, 2623-2628.
http://dx.doi.org/10.1016/j.bmc.2005.01.026
[2] Stiff, D. D.; Zemaitis, M. A. Drug Metab. Dispos. 1990, 18, 888-894.
PMid:1981533
[3] Uno, H.; Kurokawa, M.; Masuda, Y.; Nishimura, H. J. Med. Chem. 1979, 22, 180-188.
http://dx.doi.org/10.1021/jm00188a011
[4] Gopalsamy, A.; Shi, M.; Golas, J.; Vogan, E.; Jacob, J.; Johnson, M.; Lee, F.; Nilakantan, R.; Petersen, R.; Svenson, K.; Chopra, R.; Tam, M. S.; Wen, Y.; Ellingboe, J.; Arndt, K.; Boschelli, F. J. Med. Chem. 2008, 51, 373-379.
http://dx.doi.org/10.1021/jm701385c
PMid:18197612
[5] Jain, M.; Kwon, C. H. J. Med. Chem. 2003, 46, 5428-5434.
http://dx.doi.org/10.1021/jm020581y
PMid:14640551
[6] Davis, L.; Effland, R. C.; Klein, J. T.; Dunn, R. W.; Geyer, H. M.; Petko, W. M. Drug Design Disc. 1992, 8, 225-240.
PMid:1356026
[7] Strupczewski, J. T.; Allen, R. C.; Gardner, B. A.; Schmid, B. L.; Stache, U.; Glamkowski, E. J.; Jones, M. C.; Ellis, D. B.; Huger, F. P.; Dunn, R. W. J. Med. Chem. 1985, 28, 761-767.
http://dx.doi.org/10.1021/jm00383a012
[8] Janssen, P. A. J.; Niemegeers, C. J. E.; Awouters, F.; Schellekens, K. H. L.; Megens, A. A. H. P.; Meert, T. F. J. Pharmacol. Exp. Ther. 1988, 244, 685-691.
[9] Nuhrich, A.; Varache-Lembege, M.; Renard, P.; Devaux, G. Eur. J. Med. Chem. 1994, 29, 75-82.
http://dx.doi.org/10.1016/0223-5234(94)90129-5
[10] Hasegawa, H. Cur. Med. Res. Opin. 2004, 20, 577-586.
http://dx.doi.org/10.1185/030079904125003313
PMid:15140322
[11] Shantharam, C. S.; Suyoga Vardhan, D. M.; Suhas, R.; Sridhara, M. B.; Channe Gowda, D. Eur. J. Med. Chem. 2013, 60, 325-332.
http://dx.doi.org/10.1016/j.ejmech.2012.12.029
PMid:23314045
[12] Villalobos, A.; Blake, J. F.; Biggers, C. K.; Butler, T. W.; Chapin, D. S.; Chen, Y. L.; Ives, J. L.; Jones, S. B.; Liston, D. R.; Nagel, A. A.; Nason, D. M.; Nielsen, J. A.; Shalaby, I. A.; White, W. F. J. Med. Chem. 1994, 37, 2721-2730.
http://dx.doi.org/10.1021/jm00043a012
[13] Rangappa, K. S.; Basappa. J. Phys. Chem. 2005, 18, 773-779.
[14] Gaint, S.; Fitton, A. Drugs 1994, 48, 253-273.
http://dx.doi.org/10.2165/00003495-199448020-00009
[15] Chuanga, Y. M. D.; Wanga, Y. S.; Kuob, Y. Y.; Tsaia, H. P.; Shyura, W. L. F. J. Ethnopharmacol. 2004, 95, 409-419.
http://dx.doi.org/10.1016/j.jep.2004.08.010
PMid:15507368
[16] Halliwell, B.; Gutteridge, J. M. C.; Arnoma, O. L. Anal. Biochem. 1987, 165, 215-219.
http://dx.doi.org/10.1016/0003-2697(87)90222-3
[17] Nishimiki, M.; Appaji, N.; Yagi, K. Biochem. Bioph. Res. Co. 1972, 46, 849-854.
http://dx.doi.org/10.1016/S0006-291X(72)80218-3
[18] Shinde, U. A.; Kulkarni, K. R.; Phadke, A. S.; Nair, A. M.; Mungantiwar, D. V. J.; Saraf, M. N. Indian J. Exp. Biol. 1999, 371, 258-261.
[19] Boman, H. G.; Kaletta, U. Biochim. Biophys. Acta 1957, 24, 619-623.
http://dx.doi.org/10.1016/0006-3002(57)90256-1
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.4.4.402-407.864
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2013, 4(4), 402-407 | doi: https://doi.org/10.5155/eurjchem.4.4.402-407.864 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.