European Journal of Chemistry 2014, 5(1), 133-137 | doi: https://doi.org/10.5155/eurjchem.5.1.133-137.923 | Get rights and content






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Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives


Ahmed Mohamed El-Agrody (1,*) , Al-Anood Mohamed Al-Dies (2) , Ahmed Mahmoud Fouda (3)

(1) Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt
(2) Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, Saudi Arabia
(3) Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, Saudi Arabia
(*) Corresponding Author

Received: 10 Sep 2013 | Accepted: 13 Oct 2013 | Published: 31 Mar 2014 | Issue Date: March 2014

Abstract


A convenient and efficient method using microwave assisted synthesis of 4H-benzo[h]chromenes (7 and 8), by the reaction of 4-methoxy-1-naphthol (1) with a mixture of aromatic aldehydes (2) and malononitrile (3) or ethyl cyanoacetate (5) and also, by the reaction of 4-methoxy-1-naphthol (1) with α-cyanocinnamonitriles (4) or ethyl α-cyanocinnamates (6) in ethanolic piperidine solution was examined. Structures of the newly synthesized compounds were established on the basis of spectral data, IR, 1H NMR, 13C NMR, 13C NMR-DEPT and MS data.


Keywords


Benzochromenes; Pyran derivatives; Microwave synthesis; 4-Methoxy-1-naphthol; α-Cyanocinnamonitriles; Ethyl α-cyanocinnamates

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DOI: 10.5155/eurjchem.5.1.133-137.923

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Funding information


King Abdulaziz City for Science and Technology (KACST)

Citations

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[2]. Ahmed M. Fouda, Mohammed A. Assiri, Ahmed Mora, Tarik E. Ali, Tarek H. Afifi, Ahmed M. El-Agrody
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[5]. Shivaputra A Patil, Siddappa A Patil, Renukadevi Patil
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[6]. Ivan N. Bardasov, Anastasiya U. Alekseeva, Denis L. Mihailov, Oleg V. Ershov, Dmitry A. Grishanov
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How to cite


El-Agrody, A.; Al-Dies, A.; Fouda, A. Eur. J. Chem. 2014, 5(1), 133-137. doi:10.5155/eurjchem.5.1.133-137.923
El-Agrody, A.; Al-Dies, A.; Fouda, A. Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives. Eur. J. Chem. 2014, 5(1), 133-137. doi:10.5155/eurjchem.5.1.133-137.923
El-Agrody, A., Al-Dies, A., & Fouda, A. (2014). Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives. European Journal of Chemistry, 5(1), 133-137. doi:10.5155/eurjchem.5.1.133-137.923
El-Agrody, Ahmed, Al-Anood Mohamed Al-Dies, & Ahmed Mahmoud Fouda. "Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives." European Journal of Chemistry [Online], 5.1 (2014): 133-137. Web. 4 Jun. 2020
El-Agrody, Ahmed, Al-Dies, Al-Anood, AND Fouda, Ahmed. "Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.1.133-137.923

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