European Journal of Chemistry

Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives

Article Sidebar

PDF
Published: Mar 31, 2013
DOI: https://doi.org/10.5155/eurjchem.4.1.10-19.707
Keywords:
Thioglycolic acid, Aromatic aldehyde, Knoevenagal reaction, Cyanoacetohydrazide, Antimicrobial activity, 4-Benzyl-1-chlorophthalazine
Section
Research Article
Issue
Vol. 4 No. 1 (2013): March 2013
Dates
Received 2012-11-09
Accepted 2012-12-17
Published 2013-03-31


Main Article Content

Ashraf Hassan Fekry Abd El-Wahab
Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
Hany Mostafa Mohamed
Chemistry Department, Faculty of Medicine, Jazan University, 82621, Jazan, Saudi Arabia
Ahmed Mohamed El-Agrody
Chemistry Department, Faculty of Science, King Khalid University, 9004, Abha, Saudi Arabia
Mohamed Ahmed El-Nassag
Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
Ahmed Hammam Bedair
Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt

Abstract

A series of triazolophthalazine derivatives (4-22) were synthesized and characterized. The structures of the newly synthesized compounds were confirmed by spectral data. The newly synthesized compounds were also screened for their antimicrobial activity.

4_1_10_19

icon graph This Abstract was viewed 2157 times | icon graph Article PDF downloaded 1509 times

How to Cite
(1)
El-Wahab, A. H. F. A.; Mohamed, H. M.; El-Agrody, A. M.; El-Nassag, M. A.; Bedair, A. H. Synthesis, Reactions and Biological Evaluation of Benzyltriazolophthalazine Derivatives. Eur. J. Chem. 2013, 4, 10-19.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Juan, L.; Yan-Fang, Z.; Yuan, Xiao-Ye, Y.; Jing-Xiong, X.; Ping, G. Molecules 2006, 11, 574-582.

[2]. Jin, S. K.; Hee-Kyung, R.; Hyen, J. P.; Sang, K. L.; Chong-Ock, L.; Hea-Young, P. C. Bioorg. Med. Chem. 2008, 16, 4545-4550.
http://dx.doi.org/10.1016/j.bmc.2008.02.049
PMid:18321715

[3]. Raposo, M. M.; Sampaio, A. M. B. A.; Kirsch, G. J. Hetero. Chem. 2005, 42, 1245-1451.

[4]. Haack, T.; Fattori, R.; Naboletano, M.; Pellacini, F.; Fronza, G.; Raffaini, G.; Janazzoli, F. Bioorg. Med. Chem. 2005, 13, 4425-4433.
http://dx.doi.org/10.1016/j.bmc.2005.04.057
PMid:15927474

[5]. Napoletano, M.; Norcini, G.; Pellacini, F.; Marchini, F.; Morazzoni, G.; Fattori, R.; Ferienga, P.; Pradella, L. Bioorg. Med. Chem. Lett. 2002, 12, 5-8.
http://dx.doi.org/10.1016/S0960-894X(01)00668-0

[6]. Napoletano, M.; Norcini, G.; Pellacini, F.; Marchini, F.; Morazzoni, G.; Fattori, R.; Ferienga, P.; Pradella, L. Bioorg. Med. Chem. Lett. 2001, 11, 33-37.
http://dx.doi.org/10.1016/S0960-894X(00)00587-4

[7]. Line, B.; Andre, T.; Patricia, M. Tertrahedron Lett. 1996, 37, 4145-4148.
http://dx.doi.org/10.1016/0040-4039(96)00743-5

[8]. Reddy, R. S.; Saravanan, K.; Kumar, P. Tertrahedron 1998, 54, 6553-6564.
http://dx.doi.org/10.1016/S0040-4020(98)00315-9

[9]. Gomha, S. M.; Riyadh, S. M. Molecules 2011, 16, 8244-8256.
http://dx.doi.org/10.3390/molecules16108244
PMid:21959297

[10]. El-Sakka, S. S.; Soliman, A. H.; Imam, A. M. Afinidad 2009, 66, 167-172.

[11]. Tsoungas, P. G.; Searcey, M. Tetrahedron Lett. 2001, 42, 6589-6592.
http://dx.doi.org/10.1016/S0040-4039(01)01302-8

[12]. Sivakumar, R.; Gnanasam, S. K.; Ramachandran, S.; Leonard, J. T. Eur. J. Med. Chem. 2002, 37, 793-801.
http://dx.doi.org/10.1016/S0223-5234(02)01405-8

[13]. Coelho, A.; Sotelo, E.; Fraiz, N. M.; Yanez, M.; Laguna, R.; Canob, E.; Ravina, E. Bioorg. Med. Chem. Lett. 2004, 14, 321-324.
http://dx.doi.org/10.1016/j.bmcl.2003.11.009
PMid:14698150

[14]. Demirayak, S.; Karaburun, A. C.; Beis, R. Eur. J. Med. Chem. 2004, 39, 1089-1095.
http://dx.doi.org/10.1016/j.ejmech.2004.09.005
PMid:15571871

[15]. Dogruer, D. S.; Sahin, M. F.; Unlu, S.; Ito, S. Arch. Pharm. 2000, 333, 79-86.
http://dx.doi.org/10.1002/(SICI)1521-4184(20004)333:4<79::AID-ARDP79>3.0.CO;2-S

[16]. Norbert, H.; Tamara, K.; Johann, K.; Angelika, P. Molecules 2007, 12, 1900-1909.
http://dx.doi.org/10.3390/12081900

[17]. Imamura, Y.; Noda, A.; Imamura, T.; Ono, Y.; Okawara, T.; Noda, H. Life Sci. 2003, 74, 29-36.
http://dx.doi.org/10.1016/j.lfs.2003.06.032
PMid:14575810

[18]. Dogruer, D. S.; Sahin, M. F.; Kupeli, E.; Yesilada, E. Turk. J. Chem. 2003, 27, 727-738.

[19]. Dogruer, D. S.; Sahin, M. F.; Kupeli, E.; Yesilada, E. Arch. Pharm. 2004, 337, 303-310.
http://dx.doi.org/10.1002/ardp.200200719
PMid:15188219

[20]. Bold, G.; Altmann, K. -H.; Frei, J.; Lang, M.; Manley, P. W.; Traxler, P.; Wietfeld, B.; Brueggen, J.; Buchdunger, E.; Cozens, R.; Ferrari, S.; Furet, P.; Hofmann, F.; MartinyBaron, G.; Mestan, J.; Roesel, J.; Sills, M.; Stover, D.; Acemoglu, F.; Boss, E.; Emmenegger, R.; Laesser, L.; Masso, E.; Roth, R.; Schlachter, C.; Vetterli, W.; Wyss, D.; Wood, J. M. J. Med. Chem. 2000, 43, 2310-2323.
http://dx.doi.org/10.1021/jm9909443

[21]. Stuart, L. F.; Daniel, F. M.; Peter, K. Nature Reviews Drug Discovery, 2005, 4, 187-188.
http://dx.doi.org/10.1038/nrd1925

[22]. Hennequin, L. F.; Stokes, E. S.; Thomas, A. P.; Johnstone, C; Ple, P. A.; Ogilvie, D. J.; Dukes, M.; Wedge, S. R.; Kendrew, J.; Curwen, J. O. J. Med. Chem. 2002, 45, 1300-1312.
http://dx.doi.org/10.1021/jm011022e

[23]. Piatnitski, E. L.; Duncton, M. A.; Kiselyov, A. S.; Katoch, R. R.; Sherman, D.; Milligan, D. L.; Balagtas, C.; Wong, W. C.; Kawakami, J.; Doody, J. F. Bioorg. Med. Chem. Lett. 2005, 15, 4696-4698.
http://dx.doi.org/10.1016/j.bmcl.2005.07.064
PMid:16143524

[24]. Matthew, A. J. D.; Evgueni, L. P.; Reeti, K. R; Leon, M. S.; Alexander, S. K.; Daniel, L. M.; Chris, B; Wai, C. W.; Joel, K.; Jacqueline, F. D. Bioorg. Med. Chem. Lett. 2006, 16, 1579-1581.
http://dx.doi.org/10.1016/j.bmcl.2005.12.045
PMid:16386418

[25]. Bromber, A. Ber. 1896, 29, 1434-1435.

[26]. Ashraf, H. F. A; Hany, M. M.; Ahmed, M. E; Mohammed, A. E.; Ahmed, H. B. Pharmaceuticals 2011, 4, 1158-1170
http://dx.doi.org/10.3390/ph4081158

[27]. European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution. Clin. Microbiol. Infect. 2000, 6, 509-515.
http://dx.doi.org/10.1046/j.1469-0691.2000.00142.x
PMid:11168187

[28]. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th ed.; NCCLS: Wayne, PA, USA, 2000; Approved Standard M7-A5.

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).