European Journal of Chemistry

Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives



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Ashraf Hassan Fekry Abd El-Wahab
Hany Mostafa Mohamed
Ahmed Mohamed El-Agrody
Mohamed Ahmed El-Nassag
Ahmed Hammam Bedair

Abstract

A series of triazolophthalazine derivatives (4-22) were synthesized and characterized. The structures of the newly synthesized compounds were confirmed by spectral data. The newly synthesized compounds were also screened for their antimicrobial activity.

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El-Wahab, A. H. F. A.; Mohamed, H. M.; El-Agrody, A. M.; El-Nassag, M. A.; Bedair, A. H. Synthesis, Reactions and Biological Evaluation of Benzyltriazolophthalazine Derivatives. Eur. J. Chem. 2013, 4, 10-19.

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References

[1]. Juan, L.; Yan-Fang, Z.; Yuan, Xiao-Ye, Y.; Jing-Xiong, X.; Ping, G. Molecules 2006, 11, 574-582.

[2]. Jin, S. K.; Hee-Kyung, R.; Hyen, J. P.; Sang, K. L.; Chong-Ock, L.; Hea-Young, P. C. Bioorg. Med. Chem. 2008, 16, 4545-4550.
http://dx.doi.org/10.1016/j.bmc.2008.02.049
PMid:18321715

[3]. Raposo, M. M.; Sampaio, A. M. B. A.; Kirsch, G. J. Hetero. Chem. 2005, 42, 1245-1451.

[4]. Haack, T.; Fattori, R.; Naboletano, M.; Pellacini, F.; Fronza, G.; Raffaini, G.; Janazzoli, F. Bioorg. Med. Chem. 2005, 13, 4425-4433.
http://dx.doi.org/10.1016/j.bmc.2005.04.057
PMid:15927474

[5]. Napoletano, M.; Norcini, G.; Pellacini, F.; Marchini, F.; Morazzoni, G.; Fattori, R.; Ferienga, P.; Pradella, L. Bioorg. Med. Chem. Lett. 2002, 12, 5-8.
http://dx.doi.org/10.1016/S0960-894X(01)00668-0

[6]. Napoletano, M.; Norcini, G.; Pellacini, F.; Marchini, F.; Morazzoni, G.; Fattori, R.; Ferienga, P.; Pradella, L. Bioorg. Med. Chem. Lett. 2001, 11, 33-37.
http://dx.doi.org/10.1016/S0960-894X(00)00587-4

[7]. Line, B.; Andre, T.; Patricia, M. Tertrahedron Lett. 1996, 37, 4145-4148.
http://dx.doi.org/10.1016/0040-4039(96)00743-5

[8]. Reddy, R. S.; Saravanan, K.; Kumar, P. Tertrahedron 1998, 54, 6553-6564.
http://dx.doi.org/10.1016/S0040-4020(98)00315-9

[9]. Gomha, S. M.; Riyadh, S. M. Molecules 2011, 16, 8244-8256.
http://dx.doi.org/10.3390/molecules16108244
PMid:21959297

[10]. El-Sakka, S. S.; Soliman, A. H.; Imam, A. M. Afinidad 2009, 66, 167-172.

[11]. Tsoungas, P. G.; Searcey, M. Tetrahedron Lett. 2001, 42, 6589-6592.
http://dx.doi.org/10.1016/S0040-4039(01)01302-8

[12]. Sivakumar, R.; Gnanasam, S. K.; Ramachandran, S.; Leonard, J. T. Eur. J. Med. Chem. 2002, 37, 793-801.
http://dx.doi.org/10.1016/S0223-5234(02)01405-8

[13]. Coelho, A.; Sotelo, E.; Fraiz, N. M.; Yanez, M.; Laguna, R.; Canob, E.; Ravina, E. Bioorg. Med. Chem. Lett. 2004, 14, 321-324.
http://dx.doi.org/10.1016/j.bmcl.2003.11.009
PMid:14698150

[14]. Demirayak, S.; Karaburun, A. C.; Beis, R. Eur. J. Med. Chem. 2004, 39, 1089-1095.
http://dx.doi.org/10.1016/j.ejmech.2004.09.005
PMid:15571871

[15]. Dogruer, D. S.; Sahin, M. F.; Unlu, S.; Ito, S. Arch. Pharm. 2000, 333, 79-86.
http://dx.doi.org/10.1002/(SICI)1521-4184(20004)333:4<79::AID-ARDP79>3.0.CO;2-S

[16]. Norbert, H.; Tamara, K.; Johann, K.; Angelika, P. Molecules 2007, 12, 1900-1909.
http://dx.doi.org/10.3390/12081900

[17]. Imamura, Y.; Noda, A.; Imamura, T.; Ono, Y.; Okawara, T.; Noda, H. Life Sci. 2003, 74, 29-36.
http://dx.doi.org/10.1016/j.lfs.2003.06.032
PMid:14575810

[18]. Dogruer, D. S.; Sahin, M. F.; Kupeli, E.; Yesilada, E. Turk. J. Chem. 2003, 27, 727-738.

[19]. Dogruer, D. S.; Sahin, M. F.; Kupeli, E.; Yesilada, E. Arch. Pharm. 2004, 337, 303-310.
http://dx.doi.org/10.1002/ardp.200200719
PMid:15188219

[20]. Bold, G.; Altmann, K. -H.; Frei, J.; Lang, M.; Manley, P. W.; Traxler, P.; Wietfeld, B.; Brueggen, J.; Buchdunger, E.; Cozens, R.; Ferrari, S.; Furet, P.; Hofmann, F.; MartinyBaron, G.; Mestan, J.; Roesel, J.; Sills, M.; Stover, D.; Acemoglu, F.; Boss, E.; Emmenegger, R.; Laesser, L.; Masso, E.; Roth, R.; Schlachter, C.; Vetterli, W.; Wyss, D.; Wood, J. M. J. Med. Chem. 2000, 43, 2310-2323.
http://dx.doi.org/10.1021/jm9909443

[21]. Stuart, L. F.; Daniel, F. M.; Peter, K. Nature Reviews Drug Discovery, 2005, 4, 187-188.
http://dx.doi.org/10.1038/nrd1925

[22]. Hennequin, L. F.; Stokes, E. S.; Thomas, A. P.; Johnstone, C; Ple, P. A.; Ogilvie, D. J.; Dukes, M.; Wedge, S. R.; Kendrew, J.; Curwen, J. O. J. Med. Chem. 2002, 45, 1300-1312.
http://dx.doi.org/10.1021/jm011022e

[23]. Piatnitski, E. L.; Duncton, M. A.; Kiselyov, A. S.; Katoch, R. R.; Sherman, D.; Milligan, D. L.; Balagtas, C.; Wong, W. C.; Kawakami, J.; Doody, J. F. Bioorg. Med. Chem. Lett. 2005, 15, 4696-4698.
http://dx.doi.org/10.1016/j.bmcl.2005.07.064
PMid:16143524

[24]. Matthew, A. J. D.; Evgueni, L. P.; Reeti, K. R; Leon, M. S.; Alexander, S. K.; Daniel, L. M.; Chris, B; Wai, C. W.; Joel, K.; Jacqueline, F. D. Bioorg. Med. Chem. Lett. 2006, 16, 1579-1581.
http://dx.doi.org/10.1016/j.bmcl.2005.12.045
PMid:16386418

[25]. Bromber, A. Ber. 1896, 29, 1434-1435.

[26]. Ashraf, H. F. A; Hany, M. M.; Ahmed, M. E; Mohammed, A. E.; Ahmed, H. B. Pharmaceuticals 2011, 4, 1158-1170
http://dx.doi.org/10.3390/ph4081158

[27]. European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution. Clin. Microbiol. Infect. 2000, 6, 509-515.
http://dx.doi.org/10.1046/j.1469-0691.2000.00142.x
PMid:11168187

[28]. National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th ed.; NCCLS: Wayne, PA, USA, 2000; Approved Standard M7-A5.

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