European Journal of Chemistry 2013, 4(1), 10-19 | doi: https://doi.org/10.5155/eurjchem.4.1.10-19.707 | Get rights and content

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Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives


Ashraf Hassan Fekry Abd El-Wahab (1,*) , Hany Mostafa Mohamed (2) , Ahmed Mohamed El-Agrody (3) , Mohamed Ahmed El-Nassag (4) , Ahmed Hammam Bedair (5)

(1) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(2) Chemistry Department, Faculty of Medicine, Jazan University, 82621, Jazan, Saudi Arabia
(3) Chemistry Department, Faculty of Science, King Khalid University, 9004, Abha, Saudi Arabia
(4) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(5) Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt
(*) Corresponding Author

Received: 09 Nov 2012 | Revised: 02 Dec 2012 | Accepted: 17 Dec 2012 | Published: 31 Mar 2013 | Issue Date: March 2013

Abstract


A series of triazolophthalazine derivatives (4-22) were synthesized and characterized. The structures of the newly synthesized compounds were confirmed by spectral data. The newly synthesized compounds were also screened for their antimicrobial activity.

4_1_10_19

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Keywords


Thioglycolic acid; Aromatic aldehyde; Knoevenagal reaction; Cyanoacetohydrazide; Antimicrobial activity; 4-Benzyl-1-chlorophthalazine

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DOI: 10.5155/eurjchem.4.1.10-19.707

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[1]. Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Zouhair Bouaziz
Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione
Acta Crystallographica Section E Crystallographic Communications  71(8), o604, 2015
DOI: 10.1107/S2056989015013894
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[2]. Ahmed Hamdy Halawa, Ahmed Abd El-Hameed Hassan, Mohamed Ahmed El-Nassag, Mahmoud Mohamed Abd El-All, GehadAbd El-Raheem Abd El-Jaleel, Essam Mohamed Eliwa, Ahmed Hammam Bedair
Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material
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[3]. Ibrahim E. El-Shamy, A.M. Abdel-Mohsen, Amer A. Alsheikh, Moustafa M.G. Fouda, Salem S. Al-Deyab, Maher A. El-Hashash
Synthesis and antimicrobial activities of S-nucleosides of 4-mesitylphthalazine-1-thiol and some new selenium-containing nucleoside analogues
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DOI: 10.1016/j.tetlet.2015.01.103
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How to cite


El-Wahab, A.; Mohamed, H.; El-Agrody, A.; El-Nassag, M.; Bedair, A. Eur. J. Chem. 2013, 4(1), 10-19. doi:10.5155/eurjchem.4.1.10-19.707
El-Wahab, A.; Mohamed, H.; El-Agrody, A.; El-Nassag, M.; Bedair, A. Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives. Eur. J. Chem. 2013, 4(1), 10-19. doi:10.5155/eurjchem.4.1.10-19.707
El-Wahab, A., Mohamed, H., El-Agrody, A., El-Nassag, M., & Bedair, A. (2013). Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives. European Journal of Chemistry, 4(1), 10-19. doi:10.5155/eurjchem.4.1.10-19.707
El-Wahab, Ashraf, Hany Mostafa Mohamed, Ahmed Mohamed El-Agrody, Mohamed Ahmed El-Nassag, & Ahmed Hammam Bedair. "Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives." European Journal of Chemistry [Online], 4.1 (2013): 10-19. Web. 3 Jun. 2023
El-Wahab, Ashraf, Mohamed, Hany, El-Agrody, Ahmed, El-Nassag, Mohamed, AND Bedair, Ahmed. "Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives" European Journal of Chemistry [Online], Volume 4 Number 1 (31 March 2013)

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