European Journal of Chemistry

Microwave assisted synthesis of 2-amino-6-methoxy-4H-benzo[h]chromene derivatives

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Published: Mar 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.1.133-137.923
Keywords:
Benzochromenes, Pyran derivatives, Microwave synthesis, 4-Methoxy-1-naphthol, α-Cyanocinnamonitriles, Ethyl α-cyanocinnamates
Section
Research Article
Issue
Vol. 5 No. 1 (2014): March 2014
Dates
Received 2013-09-10
Accepted 2013-10-13
Published 2014-03-31


Main Article Content

Ahmed Mohamed El-Agrody
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt
Al-Anood Mohamed Al-Dies
Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, Saudi Arabia
Ahmed Mahmoud Fouda
Chemistry Department, Faculty of Science, King Khalid University, Abha, 61413, Saudi Arabia

Abstract

A convenient and efficient method using microwave assisted synthesis of 4H-benzo[h]chromenes (7 and 8), by the reaction of 4-methoxy-1-naphthol (1) with a mixture of aromatic aldehydes (2) and malononitrile (3) or ethyl cyanoacetate (5) and also, by the reaction of 4-methoxy-1-naphthol (1) with α-cyanocinnamonitriles (4) or ethyl α-cyanocinnamates (6) in ethanolic piperidine solution was examined. Structures of the newly synthesized compounds were established on the basis of spectral data, IR, 1H NMR, 13C NMR, 13C NMR-DEPT and MS data.


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El-Agrody, A. M.; Al-Dies, A.-A. M.; Fouda, A. M. Microwave Assisted Synthesis of 2-Amino-6-Methoxy-4H-benzo[h]chromene Derivatives. Eur. J. Chem. 2014, 5, 133-137.

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