European Journal of Chemistry

Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material



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Ahmed Hamdy Halawa
Ahmed Abd El-Hameed Hassan
Mohamed Ahmed El-Nassag
Mahmoud Mohamed Abd El-All
GehadAbd El-Raheem Abd El-Jaleel
Essam Mohamed Eliwa
Ahmed Hammam Bedair

Abstract

We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis and spectral data (IR, MS, 1H NMR and 13C NMR). Some selected derivatives were also screened for their antioxidant and anticancer activities. The results indicated that 7-{[6-(4-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl-H-chromen-2-one has the highest antioxidant and anticancer activity in tested compounds.


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Halawa, A. H.; Hassan, A. A. E.-H.; El-Nassag, M. A.; Abd El-All, M. M.; Abd El-Jaleel, G. E.-R.; Eliwa, E. M.; Bedair, A. H. Synthesis, Reactions, Antioxidant and Anticancer Evaluation of Some Novel Coumarin Derivatives Using Ethyl 2-(2-Oxo-4-Phenyl-2H-Chromen-7-Yloxy) Acetate As a Starting Material. Eur. J. Chem. 2014, 5, 111-121.

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Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
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