European Journal of Chemistry 2010, 1(2), 67-72 | doi: https://doi.org/10.5155/eurjchem.1.2.67-72.1 | Get rights and content

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Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones


Shadia Ahmed Galal (1,*) , Ahmed S. Abdelsamie (2) , Mireya L. Rodriguez (3) , Sean M. Kerwin (4) , Hoda I. El Diwani (5)

(1) Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt
(2) Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt
(3) Department of Chemistry and Biochemistry, Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712 USA
(4) Department of Chemistry and Biochemistry, Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712 USA
(5) Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt
(*) Corresponding Author

Received: 23 Mar 2010 | Revised: 29 Apr 2010 | Accepted: 30 Apr 2010 | Published: 15 Jun 2010 | Issue Date: June 2010

Abstract


The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.

1_2_67_72_800


Keywords


Salicylate; Hydrogen bonding; DFT-Molecular dynamics; Vibrational spectroscopy; Relaxation spectroscopy

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DOI: 10.5155/eurjchem.1.2.67-72.1

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Funding information


US-Egypt Joint Science and Technology Board Fund, Administered through the USDA (BIO9-002-015)

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How to cite


Galal, S.; Abdelsamie, A.; Rodriguez, M.; Kerwin, S.; El Diwani, H. Eur. J. Chem. 2010, 1(2), 67-72. doi:10.5155/eurjchem.1.2.67-72.1
Galal, S.; Abdelsamie, A.; Rodriguez, M.; Kerwin, S.; El Diwani, H. Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones. Eur. J. Chem. 2010, 1(2), 67-72. doi:10.5155/eurjchem.1.2.67-72.1
Galal, S., Abdelsamie, A., Rodriguez, M., Kerwin, S., & El Diwani, H. (2010). Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones. European Journal of Chemistry, 1(2), 67-72. doi:10.5155/eurjchem.1.2.67-72.1
Galal, Shadia, Ahmed S. Abdelsamie, Mireya L. Rodriguez, Sean M. Kerwin, & Hoda I. El Diwani. "Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones." European Journal of Chemistry [Online], 1.2 (2010): 67-72. Web. 2 Mar. 2021
Galal, Shadia, Abdelsamie, Ahmed, Rodriguez, Mireya, Kerwin, Sean, AND El Diwani, Hoda. "Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones" European Journal of Chemistry [Online], Volume 1 Number 2 (15 June 2010)

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