European Journal of Chemistry

Stereoselective synthesis of (-) Cephalosporolide D



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Karna Ji Harkala
Laxminarayana Eppakayala
Thirumala Chary Maringanti

Abstract

A simple and efficient synthesis of eight-membered lactone, Cephalosporolide D has been accomplished from inexpensive and commercially available starting materials. This synthesis utilizes α-aminoxylation catalyzed by L-proline reaction, Jacobsen’s hydrolytic kinetic resolution and Yamaguchi macrolactonization as key steps.


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Harkala, K. J.; Eppakayala, L.; Maringanti, T. C. Stereoselective Synthesis of (-) Cephalosporolide D. Eur. J. Chem. 2014, 5, 127-132.

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