European Journal of Chemistry 2017, 8(2), 125-129. doi:10.5155/eurjchem.8.2.125-129.1553

A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives


Shashikala Kethireddy (1) , Hemalatha Kotakommula (2) , Laxminarayana Eppakayala (3) , Thirumala Chary Mariganti (4,*)

(1) Geethanjali College of Engineering and Technology, Keesara, Rangareddy, 501301, Telangana, India
(2) Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, Telangana, India
(3) Sreenidhi Institute of Science and Technology, Ghatkesar, Hyderabad, 501301, Telangana, India
(4) Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, Telangana, India
(*) Corresponding Author

Received: 11 Feb 2017, Accepted: 19 Mar 2017, Published: 30 Jun 2017

Abstract


Newly synthesized compounds containing quinoxaline ring fused with tetrazoles and oxadiazoles show array of pharmacological activities, especially, anti-inflammatory, analgesic and anticonvulsant activities. The ability to serve as surrogates or bioisosteres for carboxylic acids, esters and carboxamides made them important moieties in drug designing. Considering the importance of quinoxalines, tetrazoles and 1,3,4-oxadiazoles to both medicinal and heterocyclic chemistry, the following 2-((5-aryl-1,3,4-oxadiazol-2-yl)methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives are synthesized. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and Mass spectral data. All the synthesized derivatives were tested in vitro for their antibacterial activity.


Keywords


Tetrazole; Quinoxalines; Antiviral activity; 1,3,4-Oxadiazole; Antibacterial activity; Anticonvulsant activity

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DOI: 10.5155/eurjchem.8.2.125-129.1553

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How to cite


Kethireddy, S.; Kotakommula, H.; Eppakayala, L.; Mariganti, T. Eur. J. Chem. 2017, 8(2), 125-129. doi:10.5155/eurjchem.8.2.125-129.1553
Kethireddy, S.; Kotakommula, H.; Eppakayala, L.; Mariganti, T. A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives. Eur. J. Chem. 2017, 8(2), 125-129. doi:10.5155/eurjchem.8.2.125-129.1553
Kethireddy, S., Kotakommula, H., Eppakayala, L., & Mariganti, T. (2017). A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives. European Journal of Chemistry, 8(2), 125-129. doi:10.5155/eurjchem.8.2.125-129.1553
Kethireddy, Shashikala, Hemalatha Kotakommula, Laxminarayana Eppakayala, & Thirumala Chary Mariganti. "A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives." European Journal of Chemistry [Online], 8.2 (2017): 125-129. Web. 17 Sep. 2019
Kethireddy, Shashikala, Kotakommula, Hemalatha, Eppakayala, Laxminarayana, AND Mariganti, Thirumala. "A new facile and efficient synthesis of 2-((5-aryl-1,3,4-oxadiazol-2-yl) methoxy)-3-methyl quinoxaline and 3-methylquinoxalin-2-yl-2-(5-aryl-2H-tetrazol-2-yl)acetate derivatives" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

DOI Link: https://doi.org/10.5155/eurjchem.8.2.125-129.1553

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