

Synthesis of pyrazole, 1,3-dithiolan and thiophene derivatives pendant to thiazolo[2,3-c]-1,2,4-triazole moiety
Samia Mohamed Sayed (1)



(1) Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt
(2) Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt
(3) Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt
(*) Corresponding Author
Received: 25 Jan 2014 | Accepted: 04 Mar 2014 | Published: 30 Jun 2014 | Issue Date: June 2014
Abstract
Coupling of 5-acetyl-2-amino-4-methylthaizole diazonium sulphate (1) with 3-chloro-pentane-2,4-dione (2) afforded the thiazolo[2,3-c]-1,2,4-triazole derivative, (5). Bormination of compound (5) followed by reaction with potassium cyanide afforded bis-3-oxo-propanenitrile derivative (7) which, reacts with CS2/NaH/CH3I to afford the ketene S,S-dithioacetal, (8). Synthesis of 1,3-dithiolane (11) and thiophene (15) derivatives have been reported.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.5.2.356-362.1022
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Funding information
Aswan Faculty of Science, Aswan University, Egypt
Citations
[1]. Mohamed A. Raslan, Samia M. Sayed, Mohamed A. Khalil
Reactivity of 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)-2-nitrosoacetonitrile: A Facile One-Pot Synthesis of Benzimidazo[1,2-a]piperazine Derivatives
HETEROCYCLES 91(4), 824, 2015
DOI: 10.3987/COM-14-13160

[2]. Mohamed A. Raslan, Omran A. Omran
Synthesis and Reactivity of Enaminones: Synthesis of Some 1,3,4‐Thiadiazole Linked to Pyrazole, Pyridine, Benzimidazolopyrimidine, Pyrazolopyrimidine, Pyrazolotriazine and Triazolotriazine Derivatives
Journal of Heterocyclic Chemistry 53(4), 1121, 2016
DOI: 10.1002/jhet.2359

[3]. Kamal M. Dawood, Samia M. Sayed
Synthesis and Reactivity of Enaminones: A Facile Synthesis of Thiophene and 1,3,4‐Thiadiazole Derivatives Incorporating a Thiazole Moiety
Journal of Heterocyclic Chemistry 53(6), 1950, 2016
DOI: 10.1002/jhet.2512

[4]. Samia M. Sayed, Mohamed A. Raslan, Mohamed A. Khalil
Synthesis and Reactivity of Cyanomethyl Thiazolyl Ketone: A Facile Synthesis of Some New Azoles, Chromene, Pyridine, Thiophene, Pyrazolo[3,4-b]pyridine and Pyrimido[1,2-a]benzimidazole Derivatives
HETEROCYCLES 91(3), 610, 2015
DOI: 10.3987/COM-15-13169

[5]. Omran A. Omran, Samia M. Sayed, Mohamed A. Raslan
Iminophosphoranes in Heterocyclic Synthesis: A Facile Synthesis of Pyrido[4,3‐D]Pyrimidine and Pyrido[4,3‐D][1,3]Oxazine Derivatives via Intermolecular aza‐Wittig Reactions
Journal of Heterocyclic Chemistry 54(2), 1103, 2017
DOI: 10.1002/jhet.2680

[6]. Kamal M. Dawood, Samia M. Sayed, Mohamed A. Raslan
Synthesis of Pyrazolo[1,5‐a][1,3,5]triazine, Pyrazolo[1,5‐a]pyrimidine, and Imidazo[1,2‐b]pyrazole Derivatives Based on Imidazo[2,1‐b]thiazole Moiety
Journal of Heterocyclic Chemistry 54(4), 2405, 2017
DOI: 10.1002/jhet.2836

[7]. Mohamed A. Khalil, Mohamed A. Raslan, Samia M. Sayed
Synthesis and Reactivity of 3‐oxoprop‐1‐en‐1‐olate Derivative as a Building Block for the Synthesis of Azole and Azine Derivatives
Journal of Heterocyclic Chemistry 54(3), 1845, 2017
DOI: 10.1002/jhet.2775

[8]. Mohamed A. Raslan, Samia M. Sayed, Mohamed A. Khalil
Synthesis of Some Pyrazole, Thiazole, Pyridine, and 1,3,4‐Thiadiazole Derivatives Incorporating 2‐Thiazolyl Moiety
Journal of Heterocyclic Chemistry 53(3), 727, 2016
DOI: 10.1002/jhet.2335

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