Synthesis of pyrazole, 1,3-dithiolan and thiophene derivatives pendant to thiazolo[2,3-c]-1,2,4-triazole moiety

Samia Mohamed Sayed; Mohamed Ali Khalil; Mohamed Abd-Elmonem Raslan

doi:10.5155/eurjchem.5.2.356-362.1022

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Published: Jun 30, 2014

DOI: https://doi.org/10.5155/eurjchem.5.2.356-362.1022

Keywords:

Thiophene, 1, 3-Thiazole, 3-Dithiolane, S, S-Dithioacetal, 3-Oxopropanenitrile, Thiazolo[2, 3-c]-1, 2, 4-triazole

Section

Research Article

Issue

Vol. 5 No. 2 (2014): June 2014

Dates

Received 2014-01-25
Accepted 2014-03-04
Published 2014-06-30

Samia Mohamed Sayed

Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt

Mohamed Ali Khalil

Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt

Mohamed Abd-Elmonem Raslan

Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt

Abstract

Coupling of 5-acetyl-2-amino-4-methylthaizole diazonium sulphate (1) with 3-chloro-pentane-2,4-dione (2) afforded the thiazolo[2,3-c]-1,2,4-triazole derivative, (5). Bormination of compound (5) followed by reaction with potassium cyanide afforded bis-3-oxo-propanenitrile derivative (7) which, reacts with CS₂/NaH/CH₃I to afford the ketene S,S-dithioacetal, (8). Synthesis of 1,3-dithiolane (11) and thiophene (15) derivatives have been reported.

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Sayed, S. M.; Khalil, M. A.; Raslan, M. A.-E. Synthesis of Pyrazole, 1,3-Dithiolan and Thiophene Derivatives Pendant to thiazolo[2,3-C]-1,2,4-Triazole Moiety. Eur. J. Chem. 2014, 5, 356-362.

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