European Journal of Chemistry

Synthesis of pyrazole, 1,3-dithiolan and thiophene derivatives pendant to thiazolo[2,3-c]-1,2,4-triazole moiety



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Samia Mohamed Sayed
Mohamed Ali Khalil
Mohamed Abd-Elmonem Raslan

Abstract

Coupling of 5-acetyl-2-amino-4-methylthaizole diazonium sulphate (1) with 3-chloro-pentane-2,4-dione (2) afforded the thiazolo[2,3-c]-1,2,4-triazole derivative, (5). Bormination of compound (5) followed by reaction with potassium cyanide afforded bis-3-oxo-propanenitrile derivative (7) which, reacts with CS2/NaH/CH3I to afford the ketene S,S-dithioacetal, (8). Synthesis of 1,3-dithiolane (11) and thiophene (15) derivatives have been reported.


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Sayed, S. M.; Khalil, M. A.; Raslan, M. A.-E. Synthesis of Pyrazole, 1,3-Dithiolan and Thiophene Derivatives Pendant to thiazolo[2,3-C]-1,2,4-Triazole Moiety. Eur. J. Chem. 2014, 5, 356-362.

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Aswan Faculty of Science, Aswan University, Egypt
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