European Journal of Chemistry 2014, 5(3), 481-487 | doi: https://doi.org/10.5155/eurjchem.5.3.481-487.1054 | Get rights and content

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Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives


Fatma Fakhry Abdel-Motaal (1) , Mohamed Abd-Elmonem Raslan (2,*)

(1) Botany Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt
(2) Chemistry Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt
(*) Corresponding Author

Received: 18 Mar 2014 | Accepted: 24 Apr 2014 | Published: 30 Sep 2014 | Issue Date: September 2014

Abstract


Several new substituted sulfonamides and sulfinyl compound derivatives were obtained by the reaction of 2-thioxo-1,2,4-triazolo[1,5-a]pyridine and pyrimidine thiol derivatives with (2-chloromethyl)benzimidazole and/or (2-chloromethyl)benzooxazole. Structures of the newly synthesized products have been deduced on the basis of spectral and analytical data. The synthesized compounds were screened for their antimicrobial activity.


Keywords


Sulfinyl; Pyrimidine; Benzooxazole; Sulfonamides; Benzimidazole; Triazolopyridine

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DOI: 10.5155/eurjchem.5.3.481-487.1054

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Funding information


Faculty of Science, Aswan University, 81528 Aswan, Egypt

Citations

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[1]. Arya C. G, Ramesh Gondru, Yupeng Li, Janardhan Banothu
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry
European Journal of Medicinal Chemistry  227, 113921, 2022
DOI: 10.1016/j.ejmech.2021.113921
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[2]. Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè , Laura Legnani
Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents
Current Medicinal Chemistry  26(40), 7166, 2020
DOI: 10.2174/0929867325666180904125400
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[3]. Manel Ben Hassen, Fatma Masmoudi, Lazhar Zribi, Mohamed Trigui, Lhassane Ismaili, José Marco‐Contelles, Fakher Chabchoub
Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐ a ]pyridine Derivatives
ChemistrySelect  6(5), 945, 2021
DOI: 10.1002/slct.202004577
/

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How to cite


Abdel-Motaal, F.; Raslan, M. Eur. J. Chem. 2014, 5(3), 481-487. doi:10.5155/eurjchem.5.3.481-487.1054
Abdel-Motaal, F.; Raslan, M. Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives. Eur. J. Chem. 2014, 5(3), 481-487. doi:10.5155/eurjchem.5.3.481-487.1054
Abdel-Motaal, F., & Raslan, M. (2014). Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives. European Journal of Chemistry, 5(3), 481-487. doi:10.5155/eurjchem.5.3.481-487.1054
Abdel-Motaal, Fatma, & Mohamed Abd-Elmonem Raslan. "Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives." European Journal of Chemistry [Online], 5.3 (2014): 481-487. Web. 2 Oct. 2022
Abdel-Motaal, Fatma, AND Raslan, Mohamed. "Synthesis and antimicrobial evaluation of some 1,2,4-triazolo[1,5-a]pyridine, pyrimidine sulfonamides and sulfinyl derivatives" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

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