European Journal of Chemistry 2014, 5(3), 430-438. doi:10.5155/eurjchem.5.3.430-438.1056

Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats


Ayman Yahya El-Khateeb (1) , Nabil Abdel-Khalik Eid Azzaz (2) , Hemdan Ibrahem Mahmoud (3,*)

(1) Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt
(2) Department of Agricultural Chemistry, Faculty of Agriculture, Damietta University, Damietta, 34517, Egypt
(3) Department of Agricultural Chemistry, Faculty of Agriculture, Minia University, Minia, 61517, Egypt
(*) Corresponding Author

Received: 19 Mar 2014, Accepted: 14 Apr 2014, Published: 30 Sep 2014

Abstract


Recently, there has been more interest with antidiabetic agents commencing natural products from plants as a better treatment than currently used synthetic drugs. The high performance liquid chromatography analysis of methanolic Acalypha wilkesiana leaves extract revealed occurrence of twenty one polyphenolic compounds. Catechin is the main constituent (29.91%), followed by apigenin (20.96%), then, ellagic acid, quercetin, kampferol, ferulic acid, luteolin, pyrogallol, rutin, caffeic acid, chlorogenic acid, protocatechouic acid, p-coumaric acid, caffiene, syrigic acid, catechol and p-OH-benzoic acid in percentages of 17.54, 10.45, 7.63, 4.67, 4.61, 4.30, 3.21, 3.15, 2.10, 1.48, 1.43, 1.13, 1.09, 1.08 and 1.05%, respectively. The antidiabetic and heamatological effects of methanolic Acalypha wilkesiana leaves extract (10, 20 and 40 mg/100 g body weight) in streptozotocin diabetic rats were investigated comparing with metformin HCl (50 mg/100 g body weight) for 30 days. Our results indicated that the most effective dose of methanolic Acalypha wilkesiana leaves extract was 40 mg/100 g body weight, which decreased blood glucose level to about 77.37% in diabetic rats, compared with a percentage of 76.50% achieved by administration with metformin HCl. Furthermore, liver functions activity, kidney functions, lipid profile, atherogenic indices and haematological parameters were scrutinized in diabetic rats treated with methanolic Acalypha wilkesiana leaves extract. These results indicate that the methanolic leaves extract of Acalypha wilkesiana, have favorable effects in bringing down the severity of diabetes and justify its use in traditional medicine for the treatment of diabetes and its complications.


Keywords


Lipid profile; Antidiabetic; Haematology; Liver functions; Kidney functions; Acalypha wilkesiana

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DOI: 10.5155/eurjchem.5.3.430-438.1056

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How to cite


El-Khateeb, A.; Azzaz, N.; Mahmoud, H. Eur. J. Chem. 2014, 5(3), 430-438. doi:10.5155/eurjchem.5.3.430-438.1056
El-Khateeb, A.; Azzaz, N.; Mahmoud, H. Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats. Eur. J. Chem. 2014, 5(3), 430-438. doi:10.5155/eurjchem.5.3.430-438.1056
El-Khateeb, A., Azzaz, N., & Mahmoud, H. (2014). Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats. European Journal of Chemistry, 5(3), 430-438. doi:10.5155/eurjchem.5.3.430-438.1056
El-Khateeb, Ayman, Nabil Abdel-Khalik Eid Azzaz, & Hemdan Ibrahem Mahmoud. "Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats." European Journal of Chemistry [Online], 5.3 (2014): 430-438. Web. 17 Sep. 2019
El-Khateeb, Ayman, Azzaz, Nabil, AND Mahmoud, Hemdan. "Phytochemical constituents, hypoglycemic and haematological effects of methanolic Acalypha wilkesiana leaves extract on streptozotocin-induced diabetic rats" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.3.430-438.1056

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