European Journal of Chemistry

Synthesis of octahydroquinazolinone derivatives using silica sulfuric acid as an efficient catalyst

Main Article Content

Akbar Mobinikhaledi
Naser Foroughifar
Homila Khodaei


Octahydroquinazolinone derivatives were synthesized in moderate to high yields via one-pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of silica sulfuric acid as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work-up procedure.


icon graph This Abstract was viewed 2358 times | icon graph Article PDF downloaded 766 times

How to Cite
Mobinikhaledi, A.; Foroughifar, N.; Khodaei, H. Synthesis of Octahydroquinazolinone Derivatives Using Silica Sulfuric Acid As an Efficient Catalyst. Eur. J. Chem. 2010, 1, 291-293.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Kappe, C. O. Eur. J. Med. Chem. 2000, 35, 1043-1052.

[2]. Kung, P. -P.; Casper, M. D.; Cook, K. L.; Wilson-Lingardo, L.; Risen, L. M.; Vickers, T. A.; Ranken, R.; Blyn, L. B.; Wyatt, J. R.; Cook, P. D.; Ecker, D. J. J. Med. Chem. 1999, 42, 4705-4713.

[3]. Yarim, M.; Saraç, S.; Kiliç, F. S.; Erol, K. Il Farmaco 2003, 58, 17-24.

[4]. V Alagarsamy, V.; Pathak, U. S.; Sriram, D.; Pandeya, S. N.; Clercq E, De. Ind. J. Pharm. Sci. 2000, 62, 433-437.

[5]. Ladani, N. K.; Patel, M. P.; Patel, R. G, Arkivoc 2009, 7, 292-302.

[6]. Vanden Eynde, J. J.; Godin, J.; Mayence, A.; Maquestiau, A.; Anders, E. Synthesis 1993, 9, 867-869.

[7]. Kempter, G.; Ehrlichmann, W.; Plesse, M.; Lehm, H. -U. J. Pract. Chem. 1982, 324, 832-840.

[8]. Hassani, Z.; Islami, M. R.; Kalantari, M. Bioorg. Med. Chem. Lett. 2000, 16, 4479-4482.

[9]. Mobinikhaledi, A.; Foroughifar, N.; Karimi, G. Synth. React. Inorg. M. 2007, 37, 279-282.

[10]. Zendehdel, M.; Mobinikhaledi. A.; Asgari, A. J. Incl. Phenom. Macro. 2008, 60, 353-357.

[11]. Liu, C. -J.; Wang, J. -D. Molecules 2009, 14, 763-770.

[12]. Dondoni, A.; Massi, A.; Minghini, E.; Sabbatini, S.; Bertolasi, V. J. Org. Chem. 2003, 68, 6172-6183.

[13]. Tajbakhsh, M.; Mohajerani, B.; Heravi, M. M.; Ahmadi, A. N. J. Mol. Catal. A 2005, 236, 216-219.

[14]. Zolfigol, M. A. Tetrahedron 2001, 57, 9509-9511.

[15]. Habibi, D.; Zolfigol, M. A.; Shiri, M.; Sedaghat, A. S. Afr. J. Chem. 2008, 61, 93-96.

[16]. Salehi, P.; Zolfigol, M. A.; Shirini, F.; Baghbanzadeh, M. Curr. Org. Chem. 2006, 10, 2171-2189.

[17]. Habibi, D.; Zolfigol, M. A.; Shirini, F.; Safaiee, M.; Abedini, M.; Rahmani, P. S. Afr. J. Chem. 2007, 60, 17-19.

[18]. Bamoniri, A.; Zolfigoi, M. A.; Mohammadpoor-Baltork, I.; Mirjalili, B. F. J. Ir. Chem. Soc. 2006, 3, 85-88.

[19]. Foroughifar, N.; Mobinikhaledi, A.; Fathinajad, H. Phosphorus. Sulfur. 2003, 178, 1241-1246.

[20]. Mobinikhaledi, A.; Foroughifar, N.; Fathinajad, H. Phosphorus. Sulfur. 2004, 179, 2259-2263.

[21]. Foroughifar, N.; Mobinikhaledi, A.; Shariatzadeh, S. M.; Masoudnia, M. Asian J. Chem. 2002, 14, 782-790.

[22]. Shaabani, A.; Sarvary, A.; Rahmati, A.; Rezayan, A. H. Lett. Org. Chem. 2007, 4, 68-71.

[23]. Sabitha, G.; Reddy, K. B.; Yadav, J. S. Tetrahedron Let. 2003, 44, 6497-6499.

Most read articles by the same author(s)

Most read articles by the same author(s)


Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).