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Synthesis of some novel Schiff bases containing 1,2,4-triazole ring
Akbar Mobinikhaledi (1,*)
, Naser Foroughifar (2) , Mansooreh Khanpour (3) , Sattar Ebrahimi (4) (1) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(2) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(3) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(4) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(*) Corresponding Author
Received: 24 Mar 2010 | Accepted: 24 Mar 2010 | Published: 31 Mar 2010 | Issue Date: March 2010
Abstract
4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1H NMR and 13C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j.
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DOI: 10.5155/eurjchem.1.1.33-36.5
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Research Council of Arak University
Citations
[1]. Naesr Foroughifar, Akbar Mobinikhaledi, Sattar Ebrahimi, Maryam Kamali, Maryam Kazemi
A simple and efficient procedure for synthesis of optically active 1,2-bis(s-triazolo (Bis (S-triazolo[3,4-b][1,3,4]thiadiazole-3-yl) alkane derivatives containing L-amino acid moieties
Journal of Sulfur Chemistry 32(6), 593, 2011
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Preparation, characterization, and biological activity of some new Schiff bases derived from aminophenoxy alkyloxy benzenamines and salicylaldehyde in the presence of p-TSA, and their Zn(II) and Cu(II) complexes
Research on Chemical Intermediates 41(2), 511, 2015
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[3]. Naesr Foroughifar, Sattar Ebrahimi, Akbar Mobinikhaledi, Reza Mozafari
An efficient and convenient protocol for the synthesis of optically active [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives containing L-amino acid moieties
Heterocyclic Communications 17(5-6), , 2011
DOI: 10.1515/HC.2011.048
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A simple and efficient procedure for the synthesis of optically active s-triazolothiadiazole derivatives
Chinese Chemical Letters 23(12), 1335, 2012
DOI: 10.1016/j.cclet.2012.10.014
[5]. Vitor F Ferreira, David R da Rocha, Fernando C da Silva, Patrícia G Ferreira, Núbia A Boechat, Jorge L Magalhães
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Expert Opinion on Therapeutic Patents 23(3), 319, 2013
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[6]. Sattar Ebrahimi
Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives
European Journal of Chemistry 1(4), 322, 2010
DOI: 10.5155/eurjchem.1.4.322-324.65
[7]. Deepak Lokwani, Rajaram Azad, Aniket Sarkate, Pallu Reddanna, Devanand Shinde
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors
Bioorganic & Medicinal Chemistry 23(15), 4533, 2015
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[8]. Nadia Abdalla Khalil, Aliaa Moh Kamal, Soha Hussein Emam
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[9]. Akbar Mobinikhaledi, Mojgan Zendehdel, Parvin Safari, Ahmad Hamta, S. Mehdi Shariatzadeh
Synthesis and Biological Activity Evaluation of Some Binuclear Metal Complexes of Cu(II) and Zn(II) with Tridentate Schiff Base Ligands
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[10]. Aeysha Sultan, Mian Habib Ur Rehman, Noreen Sajjad, Ali Irfan, Irfan Ullah, Muhammad Mustaqeem, Muhammad Saleem, Syeda Laila Rubab, Muhammad Rafiq, Muhammad Khalid, Katarzyna Kotwica-Mojzych, Mariusz Mojzych, Mohammad Shahid
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PLOS ONE 15(6), e0229891, 2020
DOI: 10.1371/journal.pone.0229891
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DOI Link: https://doi.org/10.5155/eurjchem.1.1.33-36.5
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