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PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines
Shankaraiah Guruvaiah Konda (1,*)
(1) Department of Chemistry, Karamsibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, 423601, India
(*) Corresponding Author
Received: 20 Jun 2014 | Revised: 02 Aug 2014 | Accepted: 09 Aug 2014 | Published: 31 Dec 2014 | Issue Date: December 2014
Abstract
An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts.
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DOI: 10.5155/eurjchem.5.4.676-680.1110
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Funding information
University Grants Commission, New Delhi, Minor Research Project [F. No: 47-306/12(WRO)].
Citations
[1]. Douaa Salman AlMarzouq, Omniya Sayed Zaky, Abdulaziz Abdulrazaq AlNajjar, Kamal Usef Sadek
Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines
European Journal of Chemistry 7(3), 347, 2016
DOI: 10.5155/eurjchem.7.3.347-351.1473
[2]. Mohammed Loubidi, Catherine Manga, Zahira Tber, Ibtissam Bassoude, El Mokhtar Essassi, Sabine Berteina-Raboin
One-Pot SN Ar/Direct Pd-Catalyzed CH Arylation Functionalization of Pyrazolo[1,5-a ]pyrimidine at the C3 and C7 Positions
European Journal of Organic Chemistry 2018(29), 3936, 2018
DOI: 10.1002/ejoc.201800580
[3]. Joana F. Campos, Sabine Berteina-Raboin
Greener Synthesis of Nitrogen-Containing Heterocycles in Water, PEG, and Bio-Based Solvents
Catalysts 10(4), 429, 2020
DOI: 10.3390/catal10040429
[4]. Gajanan Gopinath Mandawad, Baseer Mubeen Shaikh, Santosh Subhash Chobe, Shankaraiah Guruvaiah Konda
NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines
European Journal of Chemistry 11(4), 276, 2020
DOI: 10.5155/eurjchem.11.4.276-279.2009
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DOI Link: https://doi.org/10.5155/eurjchem.5.4.676-680.1110
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European Journal of Chemistry 2014, 5(4), 676-680 | doi: https://doi.org/10.5155/eurjchem.5.4.676-680.1110 | Get rights and content
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