European Journal of Chemistry 2020, 11(4), 276-279 | doi: | Get rights and content

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NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines

Gajanan Gopinath Mandawad (1) orcid , Baseer Mubeen Shaikh (2) orcid , Santosh Subhash Chobe (3) orcid , Shankaraiah Guruvaiah Konda (4,*) orcid

(1) Department of Chemistry, Maharashtra Udayagiri College, Udgir-413517, Maharashtra, India
(2) Department of Chemistry, Sir Sayyed College, Aurangabad-431001, Maharashtra, India
(3) Organic Research Laboratory, Loknete Vyankatrao Hirey College, Nashik-422003, Maharashtra, India
(4) Department of Chemistry, Karamsibhai Jethabhai Somaiya College, Kopargaon-423601, Maharashtra, India
(*) Corresponding Author

Received: 19 Jul 2020 | Revised: 05 Sep 2020 | Accepted: 14 Sep 2020 | Published: 31 Dec 2020 | Issue Date: December 2020


A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.


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European Journal of Chemistry


Chalcones; Green synthesis; NaOH/PEG-400; o-Phenylenediamine; Operational simplicity; Benzo[b]1,4-diazepines

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DOI: 10.5155/eurjchem.11.4.276-279.2009

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How to cite

Mandawad, G.; Shaikh, B.; Chobe, S.; Konda, S. Eur. J. Chem. 2020, 11(4), 276-279. doi:10.5155/eurjchem.11.4.276-279.2009
Mandawad, G.; Shaikh, B.; Chobe, S.; Konda, S. NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines. Eur. J. Chem. 2020, 11(4), 276-279. doi:10.5155/eurjchem.11.4.276-279.2009
Mandawad, G., Shaikh, B., Chobe, S., & Konda, S. (2020). NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines. European Journal of Chemistry, 11(4), 276-279. doi:10.5155/eurjchem.11.4.276-279.2009
Mandawad, Gajanan, Baseer Mubeen Shaikh, Santosh Subhash Chobe, & Shankaraiah Guruvaiah Konda. "NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines." European Journal of Chemistry [Online], 11.4 (2020): 276-279. Web. 3 Jun. 2023
Mandawad, Gajanan, Shaikh, Baseer, Chobe, Santosh, AND Konda, Shankaraiah. "NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines" European Journal of Chemistry [Online], Volume 11 Number 4 (31 December 2020)

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