European Journal of Chemistry 2010, 1(3), 232-235. doi:10.5155/eurjchem.1.3.232-235.112

DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues


Yahia Shirazi Beheshtia (1) , Maliheh Khorshidi (2) , Majid Momahed Heravi (3,*) , Bita Baghernejad (4)

(1) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(2) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(3) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(4) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(*) Corresponding Author

Received: 17 May 2010, Accepted: 08 Jul 2010, Published: 29 Sep 2010

Abstract


3-cyano-2(1H)-pyridinones and their 2-imino analogues have been synthesized in good yields via a one-pot multi-component reaction of 3,4-dimethoxyacetophenone, malononitrile or ethylcyanoacetate, ammonium acetate and various aldehydes in the presence of  1,4-diaza-bicyclo[2,2,2]octane (DABCO) in ethanol. DABCO has been widely used as a catalyst for the organic reactions and we selected it as an efficient catalyst to synthesis of 3-cyano-pyridines. All products were characterized by melting point, IR, 1H NMR and GC/MS studies.

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Keywords


1,4-Diaza-bicyclo[2,2,2]octane; Cyano-2(1H)-pyridinones; Cyano-2(1H)-iminopyridines; 3,4-Dimethoxyacetophenone; DABCO; Catalyst

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DOI: 10.5155/eurjchem.1.3.232-235.112

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How to cite


Beheshtia, Y.; Khorshidi, M.; Heravi, M.; Baghernejad, B. Eur. J. Chem. 2010, 1(3), 232-235. doi:10.5155/eurjchem.1.3.232-235.112
Beheshtia, Y.; Khorshidi, M.; Heravi, M.; Baghernejad, B. DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues. Eur. J. Chem. 2010, 1(3), 232-235. doi:10.5155/eurjchem.1.3.232-235.112
Beheshtia, Y., Khorshidi, M., Heravi, M., & Baghernejad, B. (2010). DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues. European Journal of Chemistry, 1(3), 232-235. doi:10.5155/eurjchem.1.3.232-235.112
Beheshtia, Yahia, Maliheh Khorshidi, Majid Momahed Heravi, & Bita Baghernejad. "DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues." European Journal of Chemistry [Online], 1.3 (2010): 232-235. Web. 22 Sep. 2019
Beheshtia, Yahia, Khorshidi, Maliheh, Heravi, Majid, AND Baghernejad, Bita. "DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues" European Journal of Chemistry [Online], Volume 1 Number 3 (29 September 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.3.232-235.112

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