European Journal of Chemistry

DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues

Main Article Content

Yahia Shirazi Beheshtia
Maliheh Khorshidi
Majid Momahed Heravi
Bita Baghernejad


3-cyano-2(1H)-pyridinones and their 2-imino analogues have been synthesized in good yields via a one-pot multi-component reaction of 3,4-dimethoxyacetophenone, malononitrile or ethylcyanoacetate, ammonium acetate and various aldehydes in the presence of  1,4-diaza-bicyclo[2,2,2]octane (DABCO) in ethanol. DABCO has been widely used as a catalyst for the organic reactions and we selected it as an efficient catalyst to synthesis of 3-cyano-pyridines. All products were characterized by melting point, IR, 1H NMR and GC/MS studies.


icon graph This Abstract was viewed 1668 times | icon graph Article PDF downloaded 1263 times

How to Cite
Beheshtia, Y. S.; Khorshidi, M.; Heravi, M. M.; Baghernejad, B. DABCO As an Efficient Catalyst for the Synthesis of 3-Cyano-2(1H)-Pyridinones and Their 2-Imino Analogues. Eur. J. Chem. 2010, 1, 232-235.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Roth, H. J.; Kleemann, A. Pharmaceutical Chemistry; Eds.; Vol. 1: Drug Synthesis; John Wiley & Sons: New York, 1988.

[2]. Doe, K.; Avasthi, K.; Pratap, R.; Bakuni, D. S.; Joshi, M. N. Indian. J. Chem. 1990, 29, 459-463.

[3]. Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Ananthan, S.; Ullas, G. V. Tetrahedron Lett. 1983, 24, 4611-4612.

[4]. Barili, P. L.; Biagi, G.; Livi, O.; Mucci, L.; Scartoni, V. J. Heterocycl. Chem. 1987, 24, 997-1001.

[5]. Attia, A.; Michael, M. Pharmazie. 1982, 37, 551-553.

[6]. Kambe, S.; Saito, K. Synthesis. 1980, 5, 365-368.

[7]. Domling, A.; Ugi, I. Angew. Chem. Int. Ed. 2000, 39, 3168-3210.

[8]. Domling, A. Comb. Chem. 1998, 1, 1-22.

[9]. Pan. J. F.; Chen, K. Tetrahedron Lett. 2004, 45, 2541-2543.

[10]. Sheen, W. C.; Lazanov, M.; Rejic, O. Tetrahedron Lett. 2003, 44, 6943-6945.

[11]. Takkewaki, T.; Beck, L. W.; Danis, M. E. Micropor. Mesopor. Mater. 1999, 33, 197-207.

[12]. Veeraraghavan, P.; Michael, R.; Rudd, T.; Reddy, M. V. R. Tetrahedron Lett. 1999, 40, 3819-3822.

[13]. Basavaiah, D.; Bharathi, T. K.; Gawzeswaie, V. V. L. Tetrahedron Lett. 1987, 28, 4352-4651.

[14]. Basavaiah, D.; Gawriswari; V. V. L.; Baharathine, T. K. Tetrahedron Lett. 1987, 28, 4591-4592.

[15]. Bamoharram, F. F.; Heravi, M. M.; Roshani, M.; Gharib, A.; Jahangir, M. Appl. Catal. 2006, 302, 42-47.

[16]. Heravi, M. M.; Hekmatshoar, R.; Pedram, L. J. Mol. Catal. A. Chem. 2005, 231, 89-91.

[17]. Heravi, M. M.; Bakhtiari, K.; Oskooie, H. A. J. Chin. Chem. Soc. 2007, 54, 579-581.

[18]. Heravi, M. M.; Oskooie, H. A.; Baghernejad, B. J. Chin. Chem. Soc. 2007, 54, 767-770.

[19]. Lin, X.; Poeppelmeier, K. R.; Weitz, E. Appl. Catal. A: Gen. 2010, 381, 114-120.

[20]. Abadi, A.; Al-Deeb, O.; Al-Afify, A.; El-Kashef, H. Farmaco II 1999, 54, 195-201.

[21]. Heravi, M. M.; Beheshtia, Y. S.; Khorshidi, M.; Baghernejad, B.; Bamoharram, F. Chin. J. Chem. 2009, 27, 569-572.

Supporting Agencies

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).