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DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues
Yahia Shirazi Beheshtia (1)
, Maliheh Khorshidi (2) , Majid Momahed Heravi (3,*) , Bita Baghernejad (4) (1) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(2) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(3) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(4) Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, IR19569, Iran
(*) Corresponding Author
Received: 17 May 2010 | Revised: 03 Aug 2010 | Accepted: 08 Jul 2010 | Published: 29 Sep 2010 | Issue Date: September 2010
Abstract
3-cyano-2(1H)-pyridinones and their 2-imino analogues have been synthesized in good yields via a one-pot multi-component reaction of 3,4-dimethoxyacetophenone, malononitrile or ethylcyanoacetate, ammonium acetate and various aldehydes in the presence of 1,4-diaza-bicyclo[2,2,2]octane (DABCO) in ethanol. DABCO has been widely used as a catalyst for the organic reactions and we selected it as an efficient catalyst to synthesis of 3-cyano-pyridines. All products were characterized by melting point, IR, 1H NMR and GC/MS studies.
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DOI: 10.5155/eurjchem.1.3.232-235.112
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Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran
Citations
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Journal of Saudi Chemical Society 18(5), 535, 2014
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DOI Link: https://doi.org/10.5155/eurjchem.1.3.232-235.112
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