European Journal of Chemistry 2012, 3(1), 125-128. doi:10.5155/eurjchem.3.1.125-128.182

Potassium hydrogen sulfate: An efficient catalyst in organic reactions

Bita Baghernejad (1,*)

(1) Department of Chemistry, School of Sciences, Payame Noor University, Ramsar, IR19569, Iran
(*) Corresponding Author

Received: 23 Jun 2010, Accepted: 04 Nov 2010, Published: 31 Mar 2012


Potassium hydrogen sulfate, KHSO4, has been used in many organic preparations as a good solid catalyst. The KHSO4 has received considerable attention since it is an inexpensive, eco-friendly, highly reactive, easy to handle and non-toxic catalyst for various organic transformations, affording the corresponding products in excellent yields with high selectivity. We wish to report some applications of this catalyst in organic reactions.



Catalyst; Non-toxic; Applications; Organic reactions; Organic transformations; Potassium hydrogen sulfate

Full Text:

PDF /    /

DOI: 10.5155/eurjchem.3.1.125-128.182

Article Metrics

This Abstract was viewed 1743 times | PDF Article downloaded 1683 times



[1]. N. Venkatesham, K. Rajendar Reddy, K. C. Rajanna, P. Veerasomaiah
Ammonium metavanadate/thiocyanate-triggered electrophilic thiocyanation of aromatic and heteroaromatic compounds in aqueous bisulfate and acetonitrile media
Journal of Sulfur Chemistry  35(6), 606, 2014
DOI: 10.1080/17415993.2014.940350

[2]. Dwipen Kakati, Nabin C. Barua
Total synthesis and assignment of the absolute stereochemistry of xanthoangelol J: development of a highly efficient method for Claisen–Schmidt condensation
Tetrahedron  70(3), 637, 2014
DOI: 10.1016/j.tet.2013.11.106

[3]. S. Harisha, Jathi Keshavayya, B.E. Kumara Swamy, S.M. Prasanna, C.C. Viswanath, B.N. Ravi
Catalytic approach green synthesis, characterization and electrochemical studies of heterocyclic azo dye derived from 5-amino-1,3,4-thiadiazole-2-thiol
Journal of Molecular Liquids  271, 976, 2018
DOI: 10.1016/j.molliq.2018.10.156

Publisher’s Note
Journal of Molecular Liquids  271, 136, 2018
DOI: 10.1016/j.molliq.2018.08.091

[5]. Bita Baghernejad
ChemInform Abstract: Potassium Hydrogen Sulfate, an Efficient Catalyst in Organic Reactions
ChemInform  43(30), no, 2012
DOI: 10.1002/chin.201230263


[1]. Wang, B.; Gu, Y.; Luo, C.; Yang, T.; Yang, L.; Suo, J. Tetrahedron Lett. 2004, 45, 3369-3372.

[2]. Corma, A.; Garcia, H. Catal. Today 1997, 38, 257-308.

[3]. Sikdar, S. K.; Howell, S. G. J. Clean. Product. 1998, 6, 253-259.

[4]. Sheldon, R. A.; Downing, R. S. Appl. Catal. A Gen. 1999, 189, 163-183.

[5]. Sartori, G.; Ballini, R.; Bigi, F.; Bosica, G.; Maggi, R.; Righi, P. Chem. Rev. 2004, 104, 199-250.

[6]. Thottumkara, A. P.; Bowsher, M. S.; Vinod, T. K. Org. Lett. 2005, 7, 2933-2936.

[7]. Green, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, John Wiley, New York, 2nd Edn., 1991, pp. 175-221.

[8]. Cotelle, P.; Catteau, J. P. Tetrahedron Lett. 1992, 33, 3855-3858.

[9]. Heravi, M. M.; Bakhtiari, K.; Taheri, S.; Oskooie, H. A. Green Chem. 2005, 7, 867-869.

[10]. Greene, T. W. Protective Groups in Organic Synthesis, Wiley, Interscience, New York, 1981, pp. 2.

[11]. Johnson, W. S.; Harbert, C. A.; Stipanovic, R. D. J. Am. Chem. Soc. 1968, 90, 5279-5280.

[12]. Huang, Z.; Zhang, M.; Wang, Y.; Qin, Y. Synlett. 2005, 1334-1336.

[13]. Arumugam, P.; Karthikeyan, G.; Perumal, P. T. Chem. Lett. 2004, 33, 1146-1147.

[14]. Kennedy, R. O.; Zhorenes, R. D. Coumarins: Biology, Applications and Mode of Action, John Wiley and Sons, Chichester, 1997.

[15]. Zabradnik, M. The Production and Application of Fluorescent Brightening Agents, John Wiley and Sons: New York, 1992.

[16]. Murray, R. D. H.; Mendez, J.; Brown, S. A. The Natural Coumarins: Occurrence, Chemistry and Biochemistry, John Wiley and Sons: New York, 1982.

[17]. Jinhua, Q.; Jishuan, S. J. Chem. Research 2005, 8, 486-491.

[18]. Greenhill, J. V.; Lue, l. In Progress in Medical Chemistry; Ellis, G. P., Luscombe, D. K. Eds.; Elsevier: New York, 1993, Vol. 3.

[19]. Arrinmayeh, H.; Nunes, A. M.; Ornstein, P. L.; Zimmerman, D. A.; Gackenheimer, S. L.; Bruns, R. F.; Hipskind, P. A.; Britton, T. C.; Cantrell, B. E. Gehlert, D. R. J. Med. Chem. 1998, 41, 2709-2719.

[20]. Nakano, H.; Inoue, T.; Kawasaki, N.; Miyataka, H.; matsumoto, H.; Taguchi, T.; Ingaki, N.; Nagai, H.; satoh, T. Bioorg. Med. Chem. 2000, 8, 373-380.

[21]. Zaho, Z. S.; Arnaiz, D. O.; Griedel, B.; Sakata, S.; Dallas, J. L.; Whitlow, M.; Trinh, L.; Liang, A.; Morrissey, M. M.; Shaw, K. J. Bioorg. Med. Chem. Lett. 2000, 10, 963- 966.

[22]. White, A. W.; Almassy, R.; Calvert, A. H.; Curtin, N. J.; Griffin, R. J.; Hostomsky, Z.; Maegley, K.; Newell, D. R.; Srinivasan, S.; Golding, B. T. J. Med. Chem. 2000, 43, 4084-4097.

[23]. Zhu, Z.; Lippa, B.; Drach, J. C.; Townsend, L. B. J. Med. Chem. 2000, 43, 2430-2437.

[24]. Ma, H.; Wang, Y.; Wang, A. Heterocycles 2006, 68, 1669-1673.

[25]. Briegert, G.; Nestrick, T. J.; McCkenna, Ch. J. Org. Chem. 1969, 34, 3789-3790.

[26]. Adimurthy, S.; Ramachandraiah, G. Tetrahedron Lett. 2004, 45, 5251-5252.

[27]. Larsen, R. D.; Corley, E. G.; King, A. O.; Carrol, J. D.; Davis, P.; Verhoeven, T. R.; Reider, P. J.; Labelle, M.; Gauthier, J. Y.; Xiang, Y. B.; Zamboni, R. J. J. Org. Chem. 1996, 61, 3398-3405.

[28]. Roma, G.; Braccio, M. D.; Grossi, G.; Mattioli, F.; Ghia, M. Eur. J. Med. Chem. 2000, 35, 1021-1035.

[29]. Kalluraya, B.; Sreenivasa, S. Farmaco. 1998, 53, 399-404.

[30]. Selvam, N. P.; Saravanan, C.; Muralidharan, D.; Perumal, P. T. J. Hetero. Chem. 2006, 43, 1379-1382.

[31]. Heravi, M. M.; Oskooie, H. A.; Baghernejad, B. J. Chin. Chem. Soc. 2007, 54, 767-770.

[32]. Sundberg, R. J. Indoles, Academic Press, London, 1996.

[33]. Heravi, M. M.; Baghernejad, B.; Oskooie, H. A.; Hekmatshoar, R. Tetrahedron. Lett. 2008, 49, 6101-6103.

[34]. Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. J. Med. Chem. 2005, 48, 2019-2025.

[35]. Seitz, L. E.; Suling, W. J.; Reynolds, R. C. J. Med. Chem. 2002, 45, 5604-5606.

[36]. Wu, Z.; Ede, N. J. Tetrahedron Lett. 2001, 42, 8115-8118.

[37]. Katoh, A.; Yoshida, T.; Ohkanda, J. Heterocycles. 2000, 52, 911-920.

[38]. Thomas, K. R. J.; Velusamy, M.; Lin, J. T.; Chuen, C. H.; Tao, Y. T. Chem. Mater. 2005, 17, 1860-1866.

[39]. Dailey, S.; Feast, W. J.; Peace, R. J.; Sage, I. C.; Till, S.; Wood, E. L. J. Mater. Chem. 2001, 11, 2238-2243

[40]. Sascha, O.; Rudiger, F. Synlett 2004, 1509-1512.

[41]. Sessler, J. L.; Maeda, H.; Mizuno, T.; Lynch, V. M.; Furuta, H. J. Am. Chem. Soc. 2002, 124, 13474-13479

[42]. Crossley, M. J.; Johnston, L. A. Chem. Commun. 2002, 1122-1123.

[43]. Heravi, M. M.; Baghernejad, B.; Oskooie, H. A.; Hekmatshoar, R. Tetrahedron. Lett. 2008, 49, 6101-6103.

[44]. Mauzeral, D.; Westheimer, F. H. J. Am. Chem. Soc. 1955, 77, 2261-2264.

[45]. Klusa, V. Drugs. Fut. 1995, 20, 135-140.

[46]. Bretzel, R. G.; Bollen, C. C.; Maeser, E.; Federlin, K. F. Am. J. Kidney. Dis. 1993, 21, 53-64.

[47]. Bretzel, R. G.; Bollen, C. C.; Maeser, E.; Federlin, K. F. Drugs. Fut. 1992, 17, 465-469.

[48]. Boer, R.; Gekeler, V. Drugs. Fut. 1995, 20, 499-509.

[49]. Heravi, M. M.; Bakhtiari, K.; Oskooie, H. A. J. Chin. Chem. Soc. 2007, 54, 579-581.

[50]. Lounasmaa, M.; Tolvanen, A. Nat. Prod. Rep. 2000, 17, 175-192.

[51]. Zeng, X. F.; Ji, S. J.; Shen, S. S. Chin. J. Chem. 2007, 25, 1777-1782.

[52]. Xuezheng, L.; Shan, G.; Xinyu, Y.; Caihua, L.; Jianguo, Y. Yingyong Huagong 2006, 35, 177-180.

[53]. Kapoor, K. K.; Ganai, B. I.; Kumar, S.; Andotra, C. S. Synth. Commun. 2006, 36, 2727-2735.

How to cite

Baghernejad, B. Eur. J. Chem. 2012, 3(1), 125-128. doi:10.5155/eurjchem.3.1.125-128.182
Baghernejad, B. Potassium hydrogen sulfate: An efficient catalyst in organic reactions. Eur. J. Chem. 2012, 3(1), 125-128. doi:10.5155/eurjchem.3.1.125-128.182
Baghernejad, B. (2012). Potassium hydrogen sulfate: An efficient catalyst in organic reactions. European Journal of Chemistry, 3(1), 125-128. doi:10.5155/eurjchem.3.1.125-128.182
Baghernejad, Bita. "Potassium hydrogen sulfate: An efficient catalyst in organic reactions." European Journal of Chemistry [Online], 3.1 (2012): 125-128. Web. 22 Sep. 2019
Baghernejad, Bita. "Potassium hydrogen sulfate: An efficient catalyst in organic reactions" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

DOI Link:


  • There are currently no refbacks.

Copyright (c)

© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.