European Journal of Chemistry 2010, 1(4), 282-288 | doi: | Get rights and content

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Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes

Mohamed Ahmed Badawy (1) , Gehad Genidy Mohamed (2,*) , Mohamed Mohamed Omar (3) , Mamdouh Mohammed Nassar (4) , Ahmed Badr Kamel (5)

(1) Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
(2) Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
(3) Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
(4) Insecticides Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
(5) Chemistry Department, Faculty of Science, Cairo University, Giza, EG-12613, Egypt
(*) Corresponding Author

Received: 19 May 2010 | Revised: 30 Oct 2010 | Accepted: 18 Sep 2010 | Published: 22 Dec 2010 | Issue Date: December 2010


The coordination behaviour of the quinoxaline ligand with N and O donation sites, derived from 3-(2-oxo-2-p-tolylethyl)quinoxalin-2(1H)-one (HL), towards some transition metal ions namely Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) are reported. The metal complexes are characterized based on elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance and thermal analyses (TG, DTG and DTA). The ionization constants of the quinoxaline ligand as well as the stability constants of its metal chelates are calculated spectrophotometrically at 25 oC and ionic strength = 0.1 M (1M NaCl). The chelates are found to have octahedral structure. The ligand and its chelates are subjected to thermal analyses and the different activation thermodynamic parameters are calculated from their corresponding DTG curves to throw more light on the nature of changes accompanying the thermal decomposition process of these compounds. The biological activity of the synthesized ligand and its metal complexes also are screened against the desert locust Schistocerca gregaria (Forsk) (Orthoptera-Acrididae) and its adult longevities. They showed remarkable biological activity.



Quinoxaline; Transition metal complexes; Spectroscopy; Thermal analyses; DTA/TG; Biological activity

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DOI: 10.5155/eurjchem.1.4.282-288.113

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Faculty of Science, Cairo University, Egypt



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Journal of Enzyme Inhibition and Medicinal Chemistry  31(4), 590, 2016
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[1]. Veroni, I.; Mitsopoulou, C. A.; Lahoz, F. J. J. Organomet. Chem. 2008, 693, 2451-2457.

[2]. Nikam, S. S.; Cordon, J. J.; Ortwine, D. F.; Heimbach, T. H.; Blackburn, A. C.; Vartanian, M. G.; Nelson, C. B.; Schwarz, R. D.; Boxer, P. A.; Rafferty, M. F. J. Med. Chem. 1999, 42, 2266-2271.

[3]. Auberson, Y. P.; Acklin, P.; Allgeier, H.; Biollaz, M.; Bischoff, S.; Ofner, S.; Veenstra, S. J. Bioorg. Med. Chem. Lett. 1998, 8, 71-74.

[4]. Kim, K. S.; Qian, L. G.; Dickinson, K. E. J.; Delaney, C. L.; Bird, J. E.; Waldron, T. L.; Moreland, S. Bioorg. Med. Chem. Lett. 1993, 39, 2667-2670.

[5]. Kim, K. S.; Qian, L. G.; Bird, J. E.; Dickinson, K. E. J.; Moreland, S.; Schaeffer, T. R.; Waldron, T. L.; Delaney, C. L.; Weller, H. N.; Miller, A. V. J. Med. Chem. 1993, 36, 2335-2342.

[6]. Melero, C. P.; Maya, A. B. S.; Rey, B. D.; Pelaez, R.; Caballero, E.; Medarde, M. Bioorg. Med. Chem. Lett. 2004, 14, 3771-3774.

[7]. Piras, S.; Loriga, M.; Paglietti, G. Il Farmaco 2004, 59, 185-194.

[8]. Corona, P.; Vitale, G.; Loriga, M.; Paglietti, G. Molecules 2006, 11, 998-1001.

[9]. Carta, A.; Loriga, M.; Zanetti, S.; Sechi, L. A. Il Farmaco 2003, 58, 1251-1255.

[10]. Hui, X.; Desrivot, J.; Bories, C.; Loiseau, P. M.; Franck, X.; Hocquemiller, R.; Figadere, B. Bioorg. Med. Chem. Lett. 2006, 16, 815-820.

[11]. Li, J.; Chen, J.; Zhang, L.; Wang, F.; Gui, C.; Zhang, L.; Qin, Y.; Xu, Q.; Liu, H.; Nan, F.; Shen, J.; Bai, D.; Chen, K.; Shen, X.; Jiang, H. Bioorg. Med. Chem. 2006, 14, 5527-5534.

[12]. Dianzhong, F.; Wang, M.; Wang, B. Polyhedron 1992, 11, 1109-1112.

[13]. Rani, D. S.; Lakshmi, P. V. A.; Jayatyagaraju, V. Trans. Met. Chem. 1994, 19, 75-77.

[14]. Sandhyarani, D.; Jayatyagaraju, V.; Ananthalakshmi, P. V. Indian J. Chem. 1999, 38A, 385-390.

[15]. Lakshmi, P. V. A.; Reddy, P. S.; Raju, V. J. Bull. Chem. Soc. Ethiop. 2008, 22, 385-390.

[16]. Lakshmi, P. V. A.; Reddy, P. S.; Raju, V. J. Spectrochim. Acta A 2009, 74, 52-57

[17]. Khan, S. A.; Saleem, K.; Khan, Z. Eur. J. Med. Chem. 2007, 42, 103-108.

[18]. Montoya, M. E.; Sainz, Y.; Ortega, M. A.; Ceráin, A. L.; Monge, A. Il Farmaco 1998, 53, 570-573.

[19]. Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. Eur. J. Med. Chem. 2003, 38, 791-800.

[20]. Vieites, M; Noblía, P.; Torre, M. H.; Cerecetto, H.; Lavaggi, M. L.; Filho, A. J. C.; Azqueta, A.; Cerain, A. L.; Monge, A.; Costa, B. P.; González, M.; Gambino, D. J. Inorg. Biochem. 2006, 100, 1358-1367.

[21]. Torre, M. H; Gambino, D.; Araujo, J.; Cerecetto, H.; González, M.; Lavaggi, M. L.; Azqueta, A.; Cerain, A. L.; Vega, A. M.; Abram, U.; Filho, A. J. C. Eur. J. Med. Chem. 2005, 40, 473-480.

[22]. Urquiola, C.; Gambino, D.; Cabrera, M.; Lavaggi, M. L.; Cerecetto, H.; González, M.; Cerain, A. L.; Monge, A.; Filho, A. J. C.; Torre, M. H. J. Inorg. Biochem. 2008, 102, 119-126.

[23]. Tarallo, M. B.; Urquiola, C.; Monge, A.; Pavan, F. R.; Leite, C. Q.; Torre, M. H.; Gambino, D. Met. Ions Biol. Med. 2008, 10, 865-872.

[24]. Tarallo, M. B.; Filho, A. J. C.; Vieira, E. D.; Monge, A.; Leite, C. Q.; Pavan, F. R.; Borthagaray, G.; Gambino, D.; Torre, M. H. J. Arg. Chem. Soc. 2009, 97, 80-89.

[25]. Urquiola, C.; Vieites, M.; Torre, M. H.; Cabrera, M.; Lavaggi, M. L.; Cerecetto, H.; González, M.; López de Cerain, A.; Monge, A.; Smircich, P.; Garat, B.; Gambino, D. Bioorg. Med. Chem. 2009, 17, 1623-1629.

[26]. Vogel, A. I. Quantitative Inorganic analysis Including Elemental Instrumental Analysis, 2nd Edition, Longmans, London, 1962.

[27]. Lurie J. Hand book of Analytical Chemistry, MIR Publisher, Moscow, 1975.

[28]. Andreichikov, Y. S.; Saraeva, R. F.; Fridman, A. L. Otkrytiya, Izobret., Prom. Obraztsy, Tovarnye znaki 1973, 50, 95-98; Chem. Abstract 1974, 81, 37577.

[29]. Mohamed, G. G.; El-Gamela N. E. A.; Teixidor, F. Polyhedron 2001, 20, 2689-3696.

[30]. Anderson, R. G.; Nickless, G. Anal. Chim. Acta 1967, 39, 469-477.

[31]. Nassar, M. M. Proceeding of 3rd conference of applied entomology, pp. 279–294, 2005.

[32]. Issa, I. M.; Issa, R. M.; Mahmoud, M. R.; Temerk, Y. M. Z. Physik. Chem. 1973, 254, 314-318.

[33]. Irving, H.; Williams, R. J. P. J. Chem. Soc. 1983, 3192-3210.

[34]. Olie, G. H.; Olive, S. The Chemistry of the Catalyzes Hydrogenation of Carbon Monoxide, Springer, Berlin, pp. 152, 1984.

[35]. Orgel, L. E. An Introduction to transition Metal Chemistry Ligand Field Theory, Methuen, pp. 55, 1966.

[36]. Mohamed, G. G.; El-Gamel, N. E. A. Spectrochim. Acta A 2004, 60, 3141-3151.

[37]. Sanmartin, J.; Bermejo, M. R.; Deibe, A. M. G.; Maneiro, M.; Lage, C.; Filho, A. J. C. Polyhedron 2000, 19, 185-192.

[38]. Refat, M. S.; Chandra, S.; Tyagi, M. J. Therm. Anal. Calorim. 2010, 100, 261-267.

[39]. Cotton, F. A.; Wilkinson, G.; Murillo, C. A.; Bochmann, M. Advanced Inorganic Chemistry, 6th edn.; Wiley, New York, 1999.

[40]. G. G. Mohamed, G. G.; M. A. Zayed, M. A.; N. E. A. El-Gamel, N. E. A. Spectrosc. Lett. 2000, 33, 821-832.

[41]. Ali, M. A.; Majumder, S. M. M. H.; Butcher, R. J.; Jasinski, J. P.; Jasinski, J. M. Polyhedron 1997, 16, 2749-2754.

[42]. Prasad, R.; Thankachan, P. P.; Thomas, M. T.; Pathak, R. J. Ind. Chem. Soc. 2001, 78, 28-31.

[43]. Mondal, N.; Dey, D. K.; Mitra, S.; Abdul Malik, K. M. Polyhedron 2000, 19, 2707-2711.

[44]. Coats, A. W.; Redfern, J. P. Nature 1964, 201, 68-69.

[45]. Bullerjahn, A. M.; Pfluger, H. J. T.; Stevenson, P. A. Cell Tissue Res. 2006, 325, 345-360.

How to cite

Badawy, M.; Mohamed, G.; Omar, M.; Nassar, M.; Kamel, A. Eur. J. Chem. 2010, 1(4), 282-288. doi:10.5155/eurjchem.1.4.282-288.113
Badawy, M.; Mohamed, G.; Omar, M.; Nassar, M.; Kamel, A. Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes. Eur. J. Chem. 2010, 1(4), 282-288. doi:10.5155/eurjchem.1.4.282-288.113
Badawy, M., Mohamed, G., Omar, M., Nassar, M., & Kamel, A. (2010). Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes. European Journal of Chemistry, 1(4), 282-288. doi:10.5155/eurjchem.1.4.282-288.113
Badawy, Mohamed, Gehad Genidy Mohamed, Mohamed Mohamed Omar, Mamdouh Mohammed Nassar, & Ahmed Badr Kamel. "Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes." European Journal of Chemistry [Online], 1.4 (2010): 282-288. Web. 24 Jan. 2021
Badawy, Mohamed, Mohamed, Gehad, Omar, Mohamed, Nassar, Mamdouh, AND Kamel, Ahmed. "Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes" European Journal of Chemistry [Online], Volume 1 Number 4 (22 December 2010)

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