

Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides
Ali AbdelHamid Deeb (1,*)



(1) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
(2) Department of Pharmacology, National Research Centre, Dokki, Cairo, 12622, Egypt
(3) Research and Development Sector, Unipharma Company, El-Obour City, 11828, Egypt
(*) Corresponding Author
Received: 01 Oct 2014 | Accepted: 02 Nov 2014 | Published: 31 Mar 2015 | Issue Date: March 2015
Abstract
The present study describes the chemical synthesis and antimicrobial evaluation of some new pyridazine and triazolopyridazine derivatives. The structure assignments of the new compounds are based on chemical and spectroscopic evidences. The Study results showed that derivatives 6a, 6b, 6g and 6i have promising inhibitory activity against (Micrococcus luteus). Compound 6i has also noticeable inhibition activity against (Escherichia coli) and compound 3g show remarkable activity against (Candida albicans). Rest of compounds showed moderate to low activity against the examined microorganisms.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.6.1.88-92.1166
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Funding information
Academy of Scientific Research and Technology, Grant no. 293/2005, Cairo, Egypt
Citations
[1]. Shakila Ghomashi, Reihane Ghomashi, Hamidreza Aghaei, Ahmad Reza Massah
Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part B: Two-Component Sulfonamide Hybrids
Current Medicinal Chemistry 30(5), 604, 2023
DOI: 10.2174/0929867329666220722143547

[2]. Amr Mohamed Abdelmoniem, Said Ahmed Soliman Ghozlan, Holger Butenschön, Ismail Abdelshafy Abdelhamid
A facile synthesis of 3-amino-2,5-dihydropyridazines and 4-deazatoxoflavin analogues via [3+3] atom combination
European Journal of Chemistry 7(1), 73, 2016
DOI: 10.5155/eurjchem.7.1.73-80.1371

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