European Journal of Chemistry 2015, 6(1), 88-92. doi:10.5155/eurjchem.6.1.88-92.1166

Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides


Ali AbdelHamid Deeb (1,*) , Wafaa Ibrahim El-Eraky (2) , Sebaey Mahgoub Mohamed (3)

(1) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
(2) Department of Pharmacology, National Research Centre, Dokki, Cairo, 12622, Egypt
(3) Research and Development Sector, Unipharma Company, El-Obour City, 11828, Egypt
(*) Corresponding Author

Received: 01 Oct 2014, Accepted: 02 Nov 2014, Published: 31 Mar 2015

Abstract


The present study describes the chemical synthesis and antimicrobial evaluation of some new pyridazine and triazolopyridazine derivatives. The structure assignments of the new compounds are based on chemical and spectroscopic evidences. The Study results showed that derivatives 6a, 6b, 6g and 6i have promising inhibitory activity against (Micrococcus luteus). Compound 6i has also noticeable inhibition activity against (Escherichia coli) and compound 3g show remarkable activity against (Candida albicans). Rest of compounds showed moderate to low activity against the examined microorganisms.


Keywords


Synthesis; Pyridazine; Sulfonamide; Triazolopyridazine; Antimicrobial activity; Agar plate diffusion technique

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DOI: 10.5155/eurjchem.6.1.88-92.1166

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[1]. Amr Mohamed Abdelmoniem, Said Ahmed Soliman Ghozlan, Holger Butenschön, Ismail Abdelshafy Abdelhamid
A facile synthesis of 3-amino-2,5-dihydropyridazines and 4-deazatoxoflavin analogues via [3+3] atom combination
European Journal of Chemistry  7(1), 73, 2016
DOI: 10.5155/eurjchem.7.1.73-80.1371
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References

[1]. Buonora, P. T.; Zhang, Q.; Sawko, J.; Westrum, L. J. Tetrahedron-Asymm. 2008, 19(1), 27-30.
http://dx.doi.org/10.1016/j.tetasy.2007.11.026

[2]. Sweeney, Z. K.; Dunn, J. P.; Li, Y.; Heilek, G.; Dunten, P.; Elworthy, T. R.; Han, X. C.; Harris, S. F.; Hirschfeld, D. R.; Hogg, J. H.; Huber, W.; Kaiser, A. C.; Kertesz, D. J.; Kim, W.; Mirzadegan, T.; Roepel, M. G.; Saito, Y. D.; Silva, T. M. P. C.; Swallow, S.; Tracy, J. L.; Villasenor, A.; Vora, H.; Zhou, A. S.; Klumpp, K. Bioorg. Med. Chem. Lett. 2008, 18, 4352-4354.
http://dx.doi.org/10.1016/j.bmcl.2008.06.072

[3]. Zou, X. J.; Jin, G. Y. Chin. J. Org. Chem. 2003, 23, 62-65.

[4]. Coelho, A.; Sotelo, E.; Ravina, E. Tetrahedron 2003, 59, 2477-2484.
http://dx.doi.org/10.1016/S0040-4020(03)00263-1

[5]. Wang, Z.; Wang, M.; Yao, X.; Li, Y.; Tan, J.; Wang, L.; Qiao, W.; Geng, Y.; Liu, Y.; Wang, Q. Eur. J. Med. Chem. 2012, 54, 33-41.
http://dx.doi.org/10.1016/j.ejmech.2012.04.020

[6]. Jiang, J. K.; Boxer, M. B.; Vander Heiden, M. G.; Shen, M.; Skoumbourdis, A. P.; Southall, N.; Veith, H.; Leister, W.; Austin, C. P.; Park, H. W.; Inglese, J.; Cantley, L. C.; Auld, D. S.; Thomas, C. Bioorg. Med. Chem. Lett. 2010, 20, 3387-3393.
http://dx.doi.org/10.1016/j.bmcl.2010.04.015

[7]. Refaat, H. M.; Khalil, O. M.; Kadry, H. H. Arch. Pharm. Res. 2008, 30(7), 803-811.
http://dx.doi.org/10.1007/BF02978828

[8]. Gleave, R. J.; Beswick, P. J.; Brown, A. J.; Giblin, G. M. P.; Goldsmith, P.; Haslam, C. P.; Mitchell, W. L.; Nicholson, N. H.; Page, L. W.; Patel, S.; Roomans, S.; Slingsby, B. P.; Swarbrick, M. E. Bioorg. Med. Chem. Lett. 2010, 20, 465-468.
http://dx.doi.org/10.1016/j.bmcl.2009.11.117

[9]. Xie, Z. F.; Chai, K. Y.; Piao, H. R.; Kwak, K. C.; Quan, Z. S. Bioorg. Med. Chem. Lett. 2005, 15, 4803-4805.
http://dx.doi.org/10.1016/j.bmcl.2005.07.051

[10]. Kritsanida, M.; Mouroutsou, A.; Marakos, P.; Pouli, N.; Papakonstantinou-Garoufalias, S.; Annecouque, C.; Witvrouw, M.; Clercq, E. D. Il Farmaco 2002, 57, 253-257.
http://dx.doi.org/10.1016/S0014-827X(01)01189-2

[11]. Lednicer, D.; Mitscher, L. A.; Georg, G. I. The organic chemistry of drug synthesis, Vol. 4, Wiley, New York, 1990.

[12]. El-Gaby, M. S. A.; Micky, J. A.; Taha, N. M; El-Sharief, M. A. M. S. J. Chin. Chem. Soc. 2002, 49, 407- 414.

[13]. El-Emary, T. I.; Al-Muaikel, N.; Moustafa, O. S. Phosphorus Sulfur 2002, 177, 195-210.
http://dx.doi.org/10.1080/10426500210238

[14]. Deeb, A.; Mahgoub, S. Med. Chem. Res. 2014, 23, 4559-4569.
http://dx.doi.org/10.1007/s00044-014-1011-3

[15]. Hosny, M.; El-Mariah, F.; Deeb, A. Phosphorus Sulfur 2007, 182, 1475-1482.
http://dx.doi.org/10.1080/10426500701242871

[16]. El-Mariah, F.; Nassar, E.; Hosny, M.; Deeb, A. Phosphorus Sulfur 2008, 184, 92-102.
http://dx.doi.org/10.1080/10426500802080246

[17]. Deeb, A.; Said, S. Collect. Czech. Chem. Commun. 1990, 55, 2795-2799.
http://dx.doi.org/10.1135/cccc19902795

[18]. Deeb, A.; Hassaneen, M.; Kotb, M. Heteroatom. Chem. 2005, 12, 278-282.
http://dx.doi.org/10.1002/hc.20110

[19]. Deeb, A.; El-Eraky, W.; El-Awdan, S.; Mahgoub, S. Med. Chem. Res. 2014, 23, 34-41.
http://dx.doi.org/10.1007/s00044-013-0605-5

[20]. Bauer, A. W.; Kirby, M. D. K.; Sherries, J. C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493-496.


How to cite


Deeb, A.; El-Eraky, W.; Mohamed, S. Eur. J. Chem. 2015, 6(1), 88-92. doi:10.5155/eurjchem.6.1.88-92.1166
Deeb, A.; El-Eraky, W.; Mohamed, S. Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides. Eur. J. Chem. 2015, 6(1), 88-92. doi:10.5155/eurjchem.6.1.88-92.1166
Deeb, A., El-Eraky, W., & Mohamed, S. (2015). Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides. European Journal of Chemistry, 6(1), 88-92. doi:10.5155/eurjchem.6.1.88-92.1166
Deeb, Ali, Wafaa Ibrahim El-Eraky, & Sebaey Mahgoub Mohamed. "Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides." European Journal of Chemistry [Online], 6.1 (2015): 88-92. Web. 16 Nov. 2019
Deeb, Ali, El-Eraky, Wafaa, AND Mohamed, Sebaey. "Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.1.88-92.1166

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