Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives

Wasfi Abood Al-Masoudi; Abeer Laily Mohmmed; Wamedh Hashim Abass; Najim Aboud Al-Masoudi

doi:10.5155/eurjchem.6.2.127-130.1175

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Published: Jun 30, 2015

DOI: https://doi.org/10.5155/eurjchem.6.2.127-130.1175

Keywords:

2D NMR, Antibiotics, Pyrimidine, Schiff’s bases, Antimicrobial activity, Molecular modeling study

Section

Research Article

Issue

Vol. 6 No. 2 (2015): June 2015

Dates

Received 2014-10-27
Accepted 2014-11-27
Published 2015-06-30

Wasfi Abood Al-Masoudi

Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq

Abeer Laily Mohmmed

Department of Microbiology, College of Veterinary, University of Basrah, Basrah, 61001, Iraq

Wamedh Hashim Abass

Department of Public Health, College of Veterinary, University of Basrah, Basrah, 61001, Iraq

Najim Aboud Al-Masoudi

Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq

Abstract

Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsille, Pseudomonas aeruginosa and Salmonella. Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus. All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.

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Al-Masoudi, W. A.; Mohmmed, A. L.; Abass, W. H.; Al-Masoudi, N. A. Synthesis, Antimicrobial Activity and Molecular Modeling Study of Some New Pyrimidine Derivatives. Eur. J. Chem. 2015, 6, 127-130.

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