European Journal of Chemistry 2015, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175

Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives


Wasfi Abood Al-Masoudi (1,*) , Abeer Laily Mohmmed (2) , Wamedh Hashim Abass (3) , Najim Aboud Al-Masoudi (4)

(1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(2) Department of Microbiology, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(3) Department of Public Health, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(4) Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 27 Oct 2014, Accepted: 27 Nov 2014, Published: 30 Jun 2015

Abstract


Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsille, Pseudomonas aeruginosa and Salmonella. Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus. All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.


Keywords


2D NMR; Antibiotics; Pyrimidine; Schiff’s bases; Antimicrobial activity; Molecular modeling study

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DOI: 10.5155/eurjchem.6.2.127-130.1175

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[1]. Ganbing Yao, Zhanxiang Xia, Zhihui Li
Thermodynamic study of solubility for 2-amino-4-chloro-6-methoxypyrimidine in twelve organic solvents at temperatures from 273.15 K to 323.15 K
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DOI: 10.1016/j.jct.2016.10.020
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[2]. Antonio Guirado, Enrique Alarcón, Yesica Vicente, Raquel Andreu, Delia Bautista, Jesús Gálvez
A new convenient synthetic approach to diarylpyrimidines
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DOI: 10.1016/j.tet.2016.05.018
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[3]. Wasfi Aboud Al-Masoudi, Rana Adnan Faaz, Rafid Hmedan Al-Asadi, Hazim Saad Jabbar
Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro
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How to cite


Al-Masoudi, W.; Mohmmed, A.; Abass, W.; Al-Masoudi, N. Eur. J. Chem. 2015, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, W.; Mohmmed, A.; Abass, W.; Al-Masoudi, N. Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives. Eur. J. Chem. 2015, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, W., Mohmmed, A., Abass, W., & Al-Masoudi, N. (2015). Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives. European Journal of Chemistry, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, Wasfi, Abeer Laily Mohmmed, Wamedh Hashim Abass, & Najim Aboud Al-Masoudi. "Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives." European Journal of Chemistry [Online], 6.2 (2015): 127-130. Web. 21 Oct. 2019
Al-Masoudi, Wasfi, Mohmmed, Abeer, Abass, Wamedh, AND Al-Masoudi, Najim. "Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives" European Journal of Chemistry [Online], Volume 6 Number 2 (30 June 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.2.127-130.1175

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