European Journal of Chemistry 2015, 6(2), 127-130 | doi: https://doi.org/10.5155/eurjchem.6.2.127-130.1175 | Get rights and content

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Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives


Wasfi Abood Al-Masoudi (1,*) , Abeer Laily Mohmmed (2) , Wamedh Hashim Abass (3) , Najim Aboud Al-Masoudi (4)

(1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(2) Department of Microbiology, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(3) Department of Public Health, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(4) Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 27 Oct 2014 | Accepted: 27 Nov 2014 | Published: 30 Jun 2015 | Issue Date: June 2015

Abstract


Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsille, Pseudomonas aeruginosa and Salmonella. Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus. All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.


Keywords


2D NMR; Antibiotics; Pyrimidine; Schiff’s bases; Antimicrobial activity; Molecular modeling study

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DOI: 10.5155/eurjchem.6.2.127-130.1175

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How to cite


Al-Masoudi, W.; Mohmmed, A.; Abass, W.; Al-Masoudi, N. Eur. J. Chem. 2015, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, W.; Mohmmed, A.; Abass, W.; Al-Masoudi, N. Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives. Eur. J. Chem. 2015, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, W., Mohmmed, A., Abass, W., & Al-Masoudi, N. (2015). Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives. European Journal of Chemistry, 6(2), 127-130. doi:10.5155/eurjchem.6.2.127-130.1175
Al-Masoudi, Wasfi, Abeer Laily Mohmmed, Wamedh Hashim Abass, & Najim Aboud Al-Masoudi. "Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives." European Journal of Chemistry [Online], 6.2 (2015): 127-130. Web. 19 Jun. 2021
Al-Masoudi, Wasfi, Mohmmed, Abeer, Abass, Wamedh, AND Al-Masoudi, Najim. "Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives" European Journal of Chemistry [Online], Volume 6 Number 2 (30 June 2015)

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