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Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives
Wasfi Abood Al-Masoudi (1,*)
, Abeer Laily Mohmmed (2) , Wamedh Hashim Abass (3) , Najim Aboud Al-Masoudi (4) (1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(2) Department of Microbiology, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(3) Department of Public Health, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
(4) Department of Chemistry, College of Science, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author
Received: 27 Oct 2014 | Accepted: 27 Nov 2014 | Published: 30 Jun 2015 | Issue Date: June 2015
Abstract
Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsille, Pseudomonas aeruginosa and Salmonella. Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus. All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions.
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DOI: 10.5155/eurjchem.6.2.127-130.1175
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Citations
[1]. Ganbing Yao, Zhanxiang Xia, Zhihui Li
Thermodynamic study of solubility for 2-amino-4-chloro-6-methoxypyrimidine in twelve organic solvents at temperatures from 273.15 K to 323.15 K
The Journal of Chemical Thermodynamics 105, 187, 2017
DOI: 10.1016/j.jct.2016.10.020
[2]. Antonio Guirado, Enrique Alarcón, Yesica Vicente, Raquel Andreu, Delia Bautista, Jesús Gálvez
A new convenient synthetic approach to diarylpyrimidines
Tetrahedron 72(27-28), 3922, 2016
DOI: 10.1016/j.tet.2016.05.018
[3]. Wasfi Aboud Al-Masoudi, Rana Adnan Faaz, Rafid Hmedan Al-Asadi, Hazim Saad Jabbar
Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro
European Journal of Chemistry 7(1), 102, 2016
DOI: 10.5155/eurjchem.7.1.102-106.1374
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DOI Link: https://doi.org/10.5155/eurjchem.6.2.127-130.1175
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European Journal of Chemistry 2015, 6(2), 127-130 | doi: https://doi.org/10.5155/eurjchem.6.2.127-130.1175 | Get rights and content
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