European Journal of Chemistry

Computational study and antimicrobial activity of few Dapsone Schiff base derivatives

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Published: Jun 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.2.351-355.1010
Keywords:
DFT, Dapsone, Schiff base, Antimicrobial, NMR spectroscopy, Computational study
Section
Research Article
Issue
Vol. 5 No. 2 (2014): June 2014
Dates
Received 2014-01-04
Accepted 2014-02-28
Published 2014-06-30


Main Article Content

Wasfi Abood Al-Masoudi
Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
Tamadher Mohammad Al-Tememy
Department of Microbiology, College of Veterinary, University of Basrah, Basrah, 61001, Iraq
Rafid Hmedan Al-Assadi
Department of Chemistry College of Education, University of Basrah, Basrah, 61001, Iraq

Abstract

Condensation of 4,4-diaminodiphenyl sulfone (Dapsone) with aliphatic and aromatic aldehydes yielded a few Schiff base derivatives in good yields. The optimized structural parameters (bond lengths and bond angles) of three azomethine compounds have been obtained by using the GAUSSIAN 09 program package. Conformer of compound 1 has the highest energy, which has less stability than compounds 2 and 3 at the same model. The synthesized compounds were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and fungicidal activity against Aspergillus niger and Candida albicans. All compounds exhibited potent antibacterial and antifungal activity with the reference standard ciprofloxacin and Amphotericin B, respectively.


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Al-Masoudi, W. A.; Al-Tememy, T. M.; Al-Assadi, R. H. Computational Study and Antimicrobial Activity of Few Dapsone Schiff Base Derivatives. Eur. J. Chem. 2014, 5, 351-355.

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University of Basrah, Basrah, Iraq
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