European Journal of Chemistry 2010, 1(3), 221-227. doi:10.5155/eurjchem.1.3.221-227.124

Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives


Sohail Saeed (1,*) , Naghmana Rashid (2) , Muhammad Ali (3) , Rizwan Hussain (4) , Peter G. Jones (5)

(1) Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
(2) Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, 44000, Pakistan
(3) Department of Pharmacy, University of the Punjab, Lahore, 54590, Pakistan
(4) National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan
(5) Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Braunschweig, D-38023, Germany
(*) Corresponding Author

Received: 23 May 2010, Accepted: 19 Jul 2010, Published: 29 Sep 2010

Abstract


This article presents our research concerning the synthesis of new thiophene-thiourea derivatives (1-12) and their pharmacological properties. These novel thiophene-thiourea derivatives were synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The crystal structure of N,N-diphenyl-N'-(thiophene-2-carbonyl)-thiourea was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21 with unit cell dimensions of a=11.7469(5) Å, b=6.0849(2) Å, c=12.5792(6) Å, β= 117.736(7) ° and V = 795.8(6) Å3. The mass fragmentation pattern has also been discussed. The synthesized compounds were screened for their in vitro antifungal activities against the standard strains: C. Albicans, C. Glabrata, and C. Tropicalis. The compounds N-thiophene-N',N'-bis(dimethyl-phosphinoylmethyl)thiourea, N-[(4-nitro-1H-imidazol-2-yl)carbamothioyl]thiophene-2-carboxamide and N,N-diethyl-N'-(thiophene-2-carbonyl)-thiourea showed significant antifungal activities against microbial species.

1_3_221_227_800


Keywords


Thiourea derivatives; Thiophene; Single crystal structure determination; Mass fragmentation; Antifungal activity

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DOI: 10.5155/eurjchem.1.3.221-227.124

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How to cite


Saeed, S.; Rashid, N.; Ali, M.; Hussain, R.; Jones, P. Eur. J. Chem. 2010, 1(3), 221-227. doi:10.5155/eurjchem.1.3.221-227.124
Saeed, S.; Rashid, N.; Ali, M.; Hussain, R.; Jones, P. Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives. Eur. J. Chem. 2010, 1(3), 221-227. doi:10.5155/eurjchem.1.3.221-227.124
Saeed, S., Rashid, N., Ali, M., Hussain, R., & Jones, P. (2010). Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives. European Journal of Chemistry, 1(3), 221-227. doi:10.5155/eurjchem.1.3.221-227.124
Saeed, Sohail, Naghmana Rashid, Muhammad Ali, Rizwan Hussain, & Peter G. Jones. "Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives." European Journal of Chemistry [Online], 1.3 (2010): 221-227. Web. 23 Oct. 2019
Saeed, Sohail, Rashid, Naghmana, Ali, Muhammad, Hussain, Rizwan, AND Jones, Peter. "Synthesis, spectroscopic characterization, crystal structure and pharmacological properties of some novel thiophene-thiourea core derivatives" European Journal of Chemistry [Online], Volume 1 Number 3 (29 September 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.3.221-227.124

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