Email this article 
Hide
Show all
OPEN ACCESS | 
PEER-REVIEWED |
RESEARCH ARTICLE
|
DOWNLOAD PDF
|
VIEW FULL-TEXT PDF
| TOTAL VIEWS
Pyridazine and its related compounds: Part 32. Synthesis and antimicrobial evaluation of some 3-substituted amino-4,5,6-triphenylpyridazine derivatives
Ali Abdel Hamid Deeb (1,*)
, Fatma Abdel Rahman El-Mariah (2) , Heba Kamal Abd El-Mawgoud (3) (1) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
(2) Department of Chemistry, College of Women for Arts, Science and Education, Ain Shams University, Cairo, 11753, Egypt
(3) Department of Chemistry, College of Women for Arts, Science and Education, Ain Shams University, Cairo, 11753, Egypt
(*) Corresponding Author
Received: 04 Feb 2015 | Accepted: 01 May 2015 | Published: 30 Jun 2015 | Issue Date: June 2015
Abstract
3-Amino-4,5,6-triphenylpyridazine was subjected to some selected reactions with nitrous acid, formic acid/dimethylformamide, acetic anhydride, benzoyl chloride, chloroacetyl chloride, acetaldehyde, diethyl malonate, malonic acid/phosphoryl chloride, diethyl oxalate, ethyl cyanoacetate, ethyl acetoacetate, and ethyl benzoylacetate to give new 3-substituted aminopyridazine derivatives. A few sulfonamide derivatives (new) were also prepared. The structures of the synthesized compounds were proved by their infrared, mass spectra, 1H NMR, and elemental analysis. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.
Announcements
One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).
Editor-in-Chief
European Journal of Chemistry
Keywords
Full Text:
PDF
DOI: 10.5155/eurjchem.6.2.211-218.1251
Links for Article
| | | | | | |
| | | | | | |
| | | |
Related Articles
Article Metrics
This Abstract was viewed 1206 times |
PDF Article downloaded 592 times
Citations
[1]. Ali Abdel Hamid Deeb, Fatma Abdel Rahman El-Mariah, Heba Kamal Abd El-Mawgoud
Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions
European Journal of Chemistry 6(2), 204, 2015
DOI: 10.5155/eurjchem.6.2.204-210.1252
[2]. Nicolai A. Aksenov, Dmitrii A. Aksenov, Nikolai A. Arutiunov, Daria S. Aksenova, Alexander V. Aksenov, Michael Rubin
Unexpected cyclization of ortho-nitrochalcones into 2-alkylideneindolin-3-ones
RSC Advances 10(31), 18440, 2020
DOI: 10.1039/D0RA03520C
References
[1]. VanDerMey, M.; Boss, H.; Hatzelmann, A.; VanDerLaan, I. J.; Sterk, G. I.; Timmerman, H. J. Med. Chem. 2002, 45, 2520-2523.
http://dx.doi.org/10.1021/jm0110340
[2]. Bradbury, R. H.; Bath, C.; Butlin, R. J.; Dennis, M.; Heys, C.; Hunt, S. J.; James, R.; Mortlock, A. A.; Sumner, N. F.; Tang, E. K.; Telford, B.; Whiting, E.; Wilson, C. J. Med. Chem. 1997, 40, 996-1004.
http://dx.doi.org/10.1021/jm9604585
[3]. Barbara, R.; Betti, L.; Botta, M.; Corelli, F.; Giannaccini. G.; Maccari, L.; Manetti, F. G.; Strappahetti, G.; Corsano, S. J. Med. Chem. 2001, 44, 2118-3132.
[4]. Cignarella, G.; Barlocco, D. J. Heterocycl. Chem. 2002, 39, 545-550.
http://dx.doi.org/10.1002/jhet.5570390310
[5]. Mann, E.; Moisan, L.; Hou, J.; Rebek, J. Tetrahedron Lett. 2008, 49, 903-905.
http://dx.doi.org/10.1016/j.tetlet.2007.11.149
[6]. Tucker, J. A.; Allwine, D. A.; Grega, K. C.; Barbachyn, M. R.; Klock, J. L.; Adamski, J. L.; Brickner, S.; Hutchinson, S. J.; Ford, D. K.; Zurenko, C. W.; Conradi, G. E.; Burton, R. A.; Jensen, P. R. M. J. Med. Chem. 1998, 41, 3727-3735.
http://dx.doi.org/10.1021/jm980274l
[7]. Tamayo, N.; Liao, L.; Goldberg, M.; Powers, D.; Tudor, Y. Y.; Yu, V.; Wong, L. M.; Henkle, B.; Middleton, S.; Syed, R.; Harvey, T.; Jang, G.; Hungate, R.; Dominguez, C. Bioorg. Med. Chem. Lett. 2005, 15, 2409-2413.
http://dx.doi.org/10.1016/j.bmcl.2005.02.010
[8]. Benson, S. C.; Palabrica, C. A.; Snyder, J. K. J. Org. Chem. 1987, 52, 4610-4614.
http://dx.doi.org/10.1021/jo00229a034
[9]. Gyoten, M.; Nagaya, H.; Fukuda, S.; Ashida, Y.; Kawano, Y. Chem. Pharm. Bull. 2003, 51, 122-133.
http://dx.doi.org/10.1248/cpb.51.122
[10]. Piaz, V. D.; Vergelli, C.; Giovannoni, M. P.; Scheideler, A. M. A.; Petrone, G.; Zaratin, P. Il Farmaco 2003, 58, 1063-1071.
http://dx.doi.org/10.1016/S0014-827X(03)00162-9
[11]. Crespo, A.; Meyers, C.; Coelho, A.; Sotelo, E.; Fraiz, N.; Sotelo, E.; Maes, B. U. W.; Laguna, R.; Cano, E.; Lemière, G. L. F.; Ravina, E. Bioorg. Med. Chem. Lett. 2006, 16, 1080-1083.
http://dx.doi.org/10.1016/j.bmcl.2005.10.073
[12]. Drochioiu, G.; Sunel, V.; Onisco, C.; Basu, C.; Murariu, M. Roum. Biotechnol. Lett. 2001, 6, 155-165.
[13]. Tucaliuc, R. B.; Risca, I. M.; Drochioiu, G.; Mangalagiu, I. Roum. Biotechnol. Lett. 2008, 13, 3837-3842.
[14]. Schmidt P.; Druey, J. Helv. Chim. Acta. 1954, 37, 134-140.
http://dx.doi.org/10.1002/hlca.19540370116
[15]. Deeb, A.; Sterk, H.; Kappe, T. Liebigs. Ann. Chem. 1991, 11, 1225-1227.
http://dx.doi.org/10.1002/jlac.1991199101210
[16]. Staudinger, H.; Meyer, J. Helv. Chim. Acta. 1919, 2, 635-646.
http://dx.doi.org/10.1002/hlca.19190020164
[17]. Deeb, A.; Said, S. A. Collect. Czech. Chem. Commun. 1990, 55, 2795-2799.
http://dx.doi.org/10.1135/cccc19902795
[18]. Bauer, A. W.; Mkriby, M. D. K.; Sherris, J. C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493-496.
[19]. El-Mariah, F.; Nassar, E.; Hosny, M.; Deeb, A. Phosphorus Sulfur 2008, 184, 92-102.
http://dx.doi.org/10.1080/10426500802080246
[20]. Vogel, A. I.; Furniss, A.; Brian, S. Vogel's Textbook of Practical Organic Chemistry. 4th ed. Longman, 1980, pp. 651.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.6.2.211-218.1251
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
Save to Zotero
Save to Mendeley
European Journal of Chemistry 2015, 6(2), 211-218 | doi: https://doi.org/10.5155/eurjchem.6.2.211-218.1251 | Get rights and content
Refbacks
- There are currently no refbacks.
Copyright (c)
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.