Pyridazine and its related compounds: Part 32. Synthesis and antimicrobial evaluation of some 3-substituted amino-4,5,6-triphenylpyridazine derivatives

Ali Abdel Hamid Deeb; Fatma Abdel Rahman El-Mariah; Heba Kamal Abd El-Mawgoud

doi:10.5155/eurjchem.6.2.211-218.1251

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Published: Jun 30, 2015

DOI: https://doi.org/10.5155/eurjchem.6.2.211-218.1251

Keywords:

3-Aminopyridazin, Anti-microbial activity, Benzil monohydrazone, Pyridazine sulfonamides, Pyrimido[1, 2-b]pyridazines, 3-Substituted aminopyridazine

Section

Research Article

Issue

Vol. 6 No. 2 (2015): June 2015

Dates

Received 2015-02-04
Accepted 2015-05-01
Published 2015-06-30

Ali Abdel Hamid Deeb

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

Fatma Abdel Rahman El-Mariah

Department of Chemistry, College of Women for Arts, Science and Education, Ain Shams University, Cairo, 11753, Egypt

Heba Kamal Abd El-Mawgoud

Department of Chemistry, College of Women for Arts, Science and Education, Ain Shams University, Cairo, 11753, Egypt

Abstract

3-Amino-4,5,6-triphenylpyridazine was subjected to some selected reactions with nitrous acid, formic acid/dimethylformamide, acetic anhydride, benzoyl chloride, chloroacetyl chloride, acetaldehyde, diethyl malonate, malonic acid/phosphoryl chloride, diethyl oxalate, ethyl cyanoacetate, ethyl acetoacetate, and ethyl benzoylacetate to give new 3-substituted aminopyridazine derivatives. A few sulfonamide derivatives (new) were also prepared. The structures of the synthesized compounds were proved by their infrared, mass spectra,¹H NMR, and elemental analysis. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.

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Deeb, A. A. H.; El-Mariah, F. A. R.; El-Mawgoud, H. K. A. Pyridazine and Its Related Compounds: Part 32. Synthesis and Antimicrobial Evaluation of Some 3-Substituted Amino-4,5,6-Triphenylpyridazine Derivatives. Eur. J. Chem. 2015, 6, 211-218.

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