European Journal of Chemistry 2015, 6(2), 204-210. doi:10.5155/eurjchem.6.2.204-210.1252

Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions


Ali Abdel Hamid Deeb (1,*) , Fatma Abdel Rahman El-Mariah (2) , Heba Kamal Abd El-Mawgoud (3)

(1) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
(2) Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt
(3) Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt
(*) Corresponding Author

Received: 04 Feb 2015, Accepted: 25 Apr 2015, Published: 30 Jun 2015

Abstract


A new method of generating the fused heterocyclic system with bridge head nitrogen pyrimido[1,2-b]pyridazinone, from 3-amino-4,5,6-triphenylpyridazine and malonic acid in presence of phosphoryl chloride is described. The structures of the synthesized compounds were confirmed by their infrared, mass spectrum, 1H NMR and elemental analyses. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.


Keywords


3-Aminopyridazine; Anti-microbial activity; Electrophilic substitutions; Nuecleophilic substitutions; Pyaranopyrimidopyridazine; Pyrimido[1,2-b]pyridazinone

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DOI: 10.5155/eurjchem.6.2.204-210.1252

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How to cite


Deeb, A.; El-Mariah, F.; El-Mawgoud, H. Eur. J. Chem. 2015, 6(2), 204-210. doi:10.5155/eurjchem.6.2.204-210.1252
Deeb, A.; El-Mariah, F.; El-Mawgoud, H. Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions. Eur. J. Chem. 2015, 6(2), 204-210. doi:10.5155/eurjchem.6.2.204-210.1252
Deeb, A., El-Mariah, F., & El-Mawgoud, H. (2015). Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions. European Journal of Chemistry, 6(2), 204-210. doi:10.5155/eurjchem.6.2.204-210.1252
Deeb, Ali, Fatma Abdel Rahman El-Mariah, & Heba Kamal Abd El-Mawgoud. "Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions." European Journal of Chemistry [Online], 6.2 (2015): 204-210. Web. 16 Sep. 2019
Deeb, Ali, El-Mariah, Fatma, AND El-Mawgoud, Heba. "Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions" European Journal of Chemistry [Online], Volume 6 Number 2 (30 June 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.2.204-210.1252

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