Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions
Ali Abdel Hamid Deeb (1,*) , Fatma Abdel Rahman El-Mariah (2) , Heba Kamal Abd El-Mawgoud (3)
(1) Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt
(2) Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt
(3) Department of Chemistry, College of Women for Arts, Science, and Education, Ain Shams University, Cairo, 11753, Egypt
(*) Corresponding Author
Received: 04 Feb 2015, Accepted: 25 Apr 2015, Published: 30 Jun 2015
A new method of generating the fused heterocyclic system with bridge head nitrogen pyrimido[1,2-b]pyridazinone, from 3-amino-4,5,6-triphenylpyridazine and malonic acid in presence of phosphoryl chloride is described. The structures of the synthesized compounds were confirmed by their infrared, mass spectrum, 1H NMR and elemental analyses. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.
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DOI Link: https://doi.org/10.5155/eurjchem.6.2.204-210.1252
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