European Journal of Chemistry 2015, 6(3), 357-366. doi:10.5155/eurjchem.6.3.357-366.1267

Oxetanes as versatile building blocks in the total synthesis of natural products: An overview


Ahmed Mahal (1,*)

(1) Department of Chemistry of the Natural Products, School of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy
(*) Corresponding Author

Received: 27 Apr 2015, Accepted: 01 Jun 2015, Published: 30 Sep 2015

Abstract


Oxetane ring plays an important role as main core in naturally occurring compounds and has many applications in pharmaceutical industries and synthetic organic chemistry. In this review, we report a brief survey of using the oxetane ring as versatile precursors in the total synthesis of natural products. Many approaches such as cyclization, addition, oxidation, reduction, elimination, protection as well as deprotection reactions utilized to synthesize of most important oxetane-containing natural products involving taxol, (±)-merrilactone A, (±)-oxetin, L-oxetanocin, (+)-(Z)-laureatin and L-oxetanocin are also covered. We describe in this review the most common total synthesis approaches have been yet applied to synthesis of most important oxetane-containing natural products. The review is also included isolation, structure Identification of these oxetane-containing natural products. The biological activity of oxetane-containing natural products due to the oxetane ring is also defined.


Keywords


Oxetane; Anti-tumor; Drug discovery; Small molecules; Natural products; Heterocyclic synthesis

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DOI: 10.5155/eurjchem.6.3.357-366.1267

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How to cite


Mahal, A. Eur. J. Chem. 2015, 6(3), 357-366. doi:10.5155/eurjchem.6.3.357-366.1267
Mahal, A. Oxetanes as versatile building blocks in the total synthesis of natural products: An overview. Eur. J. Chem. 2015, 6(3), 357-366. doi:10.5155/eurjchem.6.3.357-366.1267
Mahal, A. (2015). Oxetanes as versatile building blocks in the total synthesis of natural products: An overview. European Journal of Chemistry, 6(3), 357-366. doi:10.5155/eurjchem.6.3.357-366.1267
Mahal, Ahmed. "Oxetanes as versatile building blocks in the total synthesis of natural products: An overview." European Journal of Chemistry [Online], 6.3 (2015): 357-366. Web. 19 Sep. 2019
Mahal, Ahmed. "Oxetanes as versatile building blocks in the total synthesis of natural products: An overview" European Journal of Chemistry [Online], Volume 6 Number 3 (30 September 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.3.357-366.1267

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