European Journal of Chemistry

5H-Dibenz[b,f]azepine based pyrazole sulphonamides: A privileged platform for probing the antimicrobial and antioxidative properties

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Honnaiah Vijay Kumar
Prasanth Kumar
Javarappa Rangaswamy
Kirugunda Udayakumar Sindhu
Nagaraja Naik


In rummage around for a novel antimicrobial and antioxidant agent with improved potency, we designed and synthesized a series of 5H-dibenz[b,f]azepine based pyrazole sulphonamides (20-40) by expedient five steps route. All compounds were characterized by physico-chemical and spectroscopic techniques. In order to probe the antimicrobial and antioxidant activities, the newly synthesized compounds were assayed for their in vitro activities. Among the compounds of the particular interest, compounds 38 and 39 emerged as outperformed antimicrobial agents than standard streptomycin and fluconazole. Molecular docking studies of compound 38 and 39 into S. aureus tyrosyl-tRNA synthetase active site was performed, and the tight fitting of the compounds in the active site and the associated high binding energy might be the reason for their antimicrobial activity. On the other hand, compounds 28-30 were found to exert positive efficacy towards antioxidant activity comparable to butylated hydroxy anisole.

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Kumar, H. V.; Kumar, P.; Rangaswamy, J.; Sindhu, K. U.; Naik, N. 5H-Dibenz[b,f]azepine Based Pyrazole Sulphonamides: A Privileged Platform for Probing the Antimicrobial and Antioxidative Properties. Eur. J. Chem. 2015, 6, 394-403.

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Supporting Agencies

NMR Research Center, Indian Institute of Science, Bangalore, India

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